公开(公告)号：US11134868B2

公开(公告)日：2021-10-05

申请号：US15922718

申请日：2018-03-15

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Melissa Tsang ,  Robert C. Mucic ,  Tyler R. Wong ,  Rui Kong ,  Barry P. Pham

IPC: A61B5/145 ,  A61B5/1486 ,  C12Q1/00 ,  B81B3/00 ,  G01N27/327 ,  C23C14/34

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.

公开(公告)号：US12064236B2

公开(公告)日：2024-08-20

申请号：US16898941

申请日：2020-06-11

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Soroush Hossein Yazdi ,  Melissa Tsang ,  Ellis Garai ,  Sadaf S. Seleh ,  Steven Lai ,  Luis A. Torres ,  Bradley Petkus ,  Xin Heng ,  Zhenzhong Sun ,  Akhil Srinivasan ,  Tyler R. Wong

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  G16H20/10

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B5/4848 ,  A61B5/7203 ,  G16H20/10

Abstract: Methods, systems, and devices for continuous glucose monitoring. More particularly, the methods, systems, and devices describe a working electrode with a GOx sensor and a background electrode in which the background electrode has no GOx sensor. The system may then compare the first signal and the second signal to detect ingestion of a medication by the user. The system may generate a sensor glucose value based on the comparison.

公开(公告)号：US20230380730A1

公开(公告)日：2023-11-30

申请号：US18316708

申请日：2023-05-12

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Melissa Tsang ,  Akhil Srinivasan ,  Bradley Petkus

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/14865

Abstract: An example device includes an electrochemical cell configured to generate a first electrical signal indicative of an amount of glucose in a fluid of a person, the electrochemical cell comprising a working electrode, a counter electrode, and a reference electrode; and a background electrode configured to not catalyze a reaction with glucose and is configured to generate a second electrical signal indicative of an amount of electrochemical interference proximate the electrochemical cell.

公开(公告)号：US20230172497A1

公开(公告)日：2023-06-08

申请号：US17980018

申请日：2022-11-03

Applicant: Medtronic MiniMed, Inc.

Inventor： Jenn-Hann L. Wang ,  Anna J. Miller ,  Chi-En Lin ,  Melissa Tsang ,  Akhil Srinivasan ,  Quyen B. Ong

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486

CPC classification number: A61B5/14546 ,  C12Q1/005 ,  A61B5/1486

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes dual layer membrane compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20220395199A1

公开(公告)日：2022-12-15

申请号：US17345511

申请日：2021-06-11

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Sarkis D. Aroyan ,  Margaret R. Miller ,  Melissa Tsang

IPC: A61B5/145 ,  A61B5/1468

Abstract: An example method for initializing a glucose sensor includes executing an initialization sequence for the glucose sensor, wherein the initialization sequence is based on one or more of parameters related to manufacturing the glucose sensor or environmental conditions of the glucose sensor that are present in vivo, and reporting glucose levels in a patient after the initialization sequence.

公开(公告)号：US20220338768A1

公开(公告)日：2022-10-27

申请号：US17226412

申请日：2021-04-09

Applicant: Medtronic MiniMed, Inc.

Inventor： Melissa Tsang ,  Michael N. Missaghi ,  Anna Miller ,  Chi-En Lin ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Nicole Abraham

IPC: A61B5/1486 ,  A61B5/145 ,  B05D1/00

Abstract: Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of hexamethyldisiloxane useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

公开(公告)号：US11311215B2

公开(公告)日：2022-04-26

申请号：US16375752

申请日：2019-04-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chi-En Lin ,  David Probst ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Melissa Tsang ,  Michael E. Miller ,  Parisa Kamgar

IPC: A61B5/145 ,  A61B5/1486 ,  G01N27/327 ,  C12Q1/54 ,  G01N27/02 ,  A61B5/00 ,  C12Q1/00

Abstract: The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

公开(公告)号：US20190008425A1

公开(公告)日：2019-01-10

申请号：US15922718

申请日：2018-03-15

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Melissa Tsang ,  Robert C. Mucic ,  Tyler R. Wong ,  Rui Kong ,  Barry P. Pham

IPC: A61B5/145 ,  B81B3/00 ,  G01N27/327

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.