公开(公告)号：US11654235B2

公开(公告)日：2023-05-23

申请号：US16569401

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Peter Ajemba ,  Steven C. Jacks ,  Robert C. Mucic ,  Tyler R. Wong ,  Melissa Tsang ,  Chi-En Lin ,  Mohsen Askarinya ,  David Probst

IPC: A61B5/1495 ,  A61B5/145 ,  A61M5/172 ,  A61M5/142 ,  A61B5/00 ,  G16H20/17

CPC classification number: A61M5/1723 ,  A61B5/1495 ,  A61B5/14532 ,  A61M5/14244 ,  A61B5/145 ,  A61B5/4839 ,  A61B2560/0223 ,  A61B2560/0228 ,  A61B2560/0238 ,  A61M2005/14208 ,  G16H20/17

Abstract: Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

公开(公告)号：US20230053254A1

公开(公告)日：2023-02-16

申请号：US17401716

申请日：2021-08-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Chi-En Lin ,  Akhil Srinivasan ,  David L. Probst ,  Melissa Tsang ,  Mohsen Askarinya ,  Riley Clayton Kimball ,  Robert McKinlay ,  Vu Nguyen ,  Wally Dong ,  Xin Heng ,  Brennan Toshner

IPC: A61B5/1468 ,  A61B5/145

Abstract: A method of testing one or more analyte sensors each comprising a first electrode; a second electrode; and a material layer disposed on or above the first electrode; the method including (a) applying a voltage potential to the first electrode with respect to the second electrode; (b) measuring a test signal comprising an output current from the first electrode that results from the application of the voltage potential; (c) using the test signal from (b) to observe an electrical characteristic of the analyte sensor; and (d) correlating the electrical characteristic a parameter associated with an electrochemical response of the analyte sensor to an analyte, wherein the testing is under dry conditions without exposure of the electrodes to a fluid containing the analyte or an in-vivo environment containing the analyte.

公开(公告)号：US20220412913A1

公开(公告)日：2022-12-29

申请号：US17898241

申请日：2022-08-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Christina Pai ,  Brian P. McGee ,  Mohsen Askarinya ,  Mary Ellen B. Coe ,  Cynthia J. Jones ,  Hsiu-Hsin Chung ,  Nathan Hobbs ,  Jorge L. Nieto ,  Anirban Chakraborty

IPC: G01N27/327

Abstract: A sensor having a distal end and an intermediate region adjacent to the distal end is provided. The sensor includes an insulator base substrate, sensor electrodes over the insulator base substrate, an electrode lead pattern over the insulator base substrate, wherein the electrode lead pattern includes electrode leads configured for contact with the sensor electrodes, and wherein the electrode leads extend completely across the intermediate region in a longitudinal direction, and a structural backing layer over the electrode lead pattern and insulator base substrate; wherein a side edge of the structural backing layer over the electrode lead pattern extends completely across the structural backing layer in the longitudinal direction.

公开(公告)号：US20220338768A1

公开(公告)日：2022-10-27

申请号：US17226412

申请日：2021-04-09

Applicant: Medtronic MiniMed, Inc.

Inventor： Melissa Tsang ,  Michael N. Missaghi ,  Anna Miller ,  Chi-En Lin ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Nicole Abraham

IPC: A61B5/1486 ,  A61B5/145 ,  B05D1/00

Abstract: Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of hexamethyldisiloxane useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

公开(公告)号：US11448611B2

公开(公告)日：2022-09-20

申请号：US16503235

申请日：2019-07-03

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Christina Pai ,  Brian P. McGee ,  Mohsen Askarinya ,  Mary Ellen B. Coe ,  Cynthia J. Jones ,  Hsiu-Hsin Chung ,  Nathan Hobbs ,  Jorge L. Nieto ,  Anirban Chakraborty

IPC: G01N27/327

Abstract: Sensors and methods for manufacturing sensors are provided. An exemplary method for manufacturing a sensor includes forming an electrode lead pattern over an insulator base substrate. Further, the method includes forming a structural backing layer over the electrode lead pattern and insulator base substrate. Also, the method includes performing a cutting process to cut through the structural backing layer to form a structural backing over the electrode lead pattern.

公开(公告)号：US11311215B2

公开(公告)日：2022-04-26

申请号：US16375752

申请日：2019-04-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chi-En Lin ,  David Probst ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Melissa Tsang ,  Michael E. Miller ,  Parisa Kamgar

IPC: A61B5/145 ,  A61B5/1486 ,  G01N27/327 ,  C12Q1/54 ,  G01N27/02 ,  A61B5/00 ,  C12Q1/00

Abstract: The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

公开(公告)号：US20210077717A1

公开(公告)日：2021-03-18

申请号：US16569401

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Peter Ajemba ,  Steven C. Jacks ,  Robert C. Mucic ,  Tyler R. Wong ,  Melissa Tsang ,  Chi-En Lin ,  Mohsen Askarinya ,  David Probst

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1495

Abstract: Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

公开(公告)号：US20200315504A1

公开(公告)日：2020-10-08

申请号：US16375752

申请日：2019-04-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chi-En Lin ,  David Probst ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Melissa Tsang ,  Michael E. Miller ,  Parisa Kamgar

IPC: A61B5/145 ,  A61B5/1486 ,  C12Q1/54 ,  G01N27/327 ,  A61B5/00

Abstract: The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

公开(公告)号：US20190090743A1

公开(公告)日：2019-03-28

申请号：US15716426

申请日：2017-09-26

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Daniel Hahn ,  David Probst ,  Randal Schulhauser ,  Mohsen Askarinya ,  Patrick W. Kinzie ,  Thomas P. Miltich ,  Mark D. Breyen ,  Santhisagar Vaddiraju

IPC: A61B5/00 ,  H01L21/48 ,  H01L21/52 ,  H01L21/78 ,  H01L23/055 ,  H01L23/498 ,  H01L23/66 ,  A61B5/145 ,  A61B5/1468

Abstract: Processes for fabricating physiological characteristic sensor devices are disclosed here. An embodiment of the fabrication process forms a circuit pattern on a base substrate, where the circuit pattern includes circuit layouts for multiple die locations. Component stacks are mounted to the circuit layouts. Each stack has features and components to provide processing and wireless communication functionality for obtained sensor data. An enclosure structure is formed overlying the base substrate to individually cover and enclose each of the component stacks. Sensor elements are fabricated on another surface of the substrate such that each sensor element has electrodes coupled to conductive plug elements formed through the substrate, and such that each sensor element corresponds to one die location. Next, the substrate is separated into physically discrete sensor device components.

公开(公告)号：US08979799B1

公开(公告)日：2015-03-17

申请号：US14134787

申请日：2013-12-19

Applicant: Medtronic MiniMed, Inc.

Inventor： Mohsen Askarinya ,  Richard L. Brown ,  Colin A. Chong ,  Patrick W. Kinzie ,  Randal Schulhauser ,  Jeff M. Cherry ,  Tyler S. Stevenson

IPC: A61M1/00 ,  A61M5/145

CPC classification number: A61M5/145 ,  A61M5/14248 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2205/825

Abstract: An electronic injector including an electronic on-body injector for use with a patient to deliver a fluid through an injection device. The electronic on-body injector includes a fluid reservoir; a MEMS pump; a bolus injection needle, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap; and a bolus needle button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis. The bolus needle button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port to form a bolus injection flow path. The bolus needle button is further operable to activate the MEMS pump to deliver a predetermined bolus volume.

Abstract translation: 一种电子注射器，其包括与患者一起使用的电子体内注射器，以通过注射装置输送流体。 电子体内注射器包括流体储存器; MEMS泵; 推注注射针，推注注射针具有与注射口对准的推注注射针头，推注注射针可滑动地偏离注射口以限定间隙; 以及推注针按钮，其可操作地连接到推注注射针以沿着注射轴线滑动推注注射针。 推注针按钮可操作以推进推注注射针尖以闭合间隙并将推注注射针尖推进注射口以形成推注注射流动路径。 推注针按钮还可操作以激活MEMS泵以输送预定的推注体积。