公开(公告)号：US10201632B2

公开(公告)日：2019-02-12

申请号：US15719241

申请日：2017-09-28

Applicant: MicroVention, Inc.

Inventor： Gloria Hincapie ,  Xinping Wu ,  Yue Wu ,  Gregory M. Cruise

IPC: A61L24/06 ,  A61L24/00 ,  A61K47/69 ,  A61K31/4745 ,  A61K31/555 ,  C08F220/56 ,  A61L31/04 ,  A61L31/14 ,  C08F236/20 ,  A61L26/00 ,  A61B17/12 ,  A61B17/00

Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US10194915B2

公开(公告)日：2019-02-05

申请号：US15272305

申请日：2016-09-21

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Terrance T. Tran

IPC: A61B17/00 ,  A61B17/12 ,  A61B90/00 ,  A61K49/04 ,  A61L24/00 ,  A61L24/04 ,  A61L27/16 ,  A61L27/18 ,  A61L27/56 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/18 ,  C08L39/06 ,  C08L71/02

Abstract: Described are devices for implantation comprising a hydrogel filament wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer, an ethylenically unsaturated monomer, and a visualization agent. Methods of making and using these devices are also described.

公开(公告)号：US10092663B2

公开(公告)日：2018-10-09

申请号：US14678468

申请日：2015-04-03

Applicant: MicroVention, Inc.

Inventor： Michael Constant ,  Gregory M. Cruise ,  Samuel Chen

IPC: A61K9/00 ,  A61K49/04 ,  D01F6/28 ,  D01D5/00 ,  D01D5/38 ,  D01F1/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18

Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.

公开(公告)号：US20180147317A1

公开(公告)日：2018-05-31

申请号：US15878294

申请日：2018-01-23

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: A61L24/06 ,  C08F222/38 ,  A61L24/00

CPC classification number: A61L24/06 ,  A61L24/001 ,  A61L2430/36 ,  C08F222/385 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

公开(公告)号：US20160243273A1

公开(公告)日：2016-08-25

申请号：US14736145

申请日：2015-06-10

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61L24/06 ,  A61K49/12 ,  A61L24/00 ,  A61K49/04

CPC classification number: A61L24/06 ,  A61K49/0442 ,  A61K49/12 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/36 ,  C08L33/08 ,  C08L33/26

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

Abstract translation: 描述了包含生物相容性聚合物的聚合物组合物，其包括与可视化试剂和非生理pH溶液的生物可降解连接; 其中所述生物相容性聚合物可溶于非生理pH溶液中，并且在生理pH下不溶。 公开了形成溶液和聚合物的方法以及治疗用途的方法。

公开(公告)号：US20160243157A1

公开(公告)日：2016-08-25

申请号：US15142395

申请日：2016-04-29

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61K9/00

CPC classification number: A61K31/785 ,  A61K9/0024 ,  A61K31/78 ,  A61K47/32 ,  A61L24/0089 ,  A61L24/046 ,  A61L2430/36

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US09408916B2

公开(公告)日：2016-08-09

申请号：US14491813

申请日：2014-09-19

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris ,  Yue Wu

IPC: C08F120/56 ,  A61K47/32 ,  A61L31/14 ,  A61L31/16 ,  A61K9/00 ,  C08F220/56 ,  C08F222/10 ,  C08F222/38

CPC classification number: C08J5/18 ,  A61K9/0024 ,  A61K47/32 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C08F120/56 ,  C08F220/56 ,  C08F222/1006 ,  C08F222/385 ,  C08J2333/14 ,  C08J2333/26 ,  Y10T428/21

Abstract: Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

Abstract translation: 描述了可生物降解的交联聚合物膜及其制备方法。 聚合物膜可以用于防止手术后和/或递送治疗剂的粘连。

公开(公告)号：US20150306255A1

公开(公告)日：2015-10-29

申请号：US14678468

申请日：2015-04-03

Applicant: MicroVention, Inc.

Inventor： Michael Constant ,  Gregory M. Cruise ,  Samuel Chen

IPC: A61K49/04 ,  D01F6/28

CPC classification number: A61K49/0404 ,  A61K49/0409 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2430/36 ,  D01D5/00 ,  D01D5/38 ,  D01F1/10 ,  D01F6/28 ,  D10B2509/00

Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.

Abstract translation: 本文描述了聚合物，其包含：预聚物溶液的反应产物，其包含至少一种大分子单体，至少一种柔性体和至少一种可视化试剂。 还描述了制备和使用这些聚合物的方法。

公开(公告)号：US20150079395A1

公开(公告)日：2015-03-19

申请号：US14491776

申请日：2014-09-19

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris

IPC: C08F220/56

CPC classification number: C08F220/38 ,  A61K9/0029 ,  A61K9/1635 ,  A61L24/001 ,  A61L24/06 ,  A61L31/048 ,  A61L2430/36 ,  C08F220/56 ,  C08F222/1006 ,  C08F222/385 ,  C08F2220/382 ,  C08F2222/408 ,  Y10T428/2982 ,  C08L33/08

Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

Abstract translation: 描述了可生物降解的交联聚合物颗粒栓塞及其制备方法。 颗粒栓塞可用作栓塞剂。

公开(公告)号：US20150079328A1

公开(公告)日：2015-03-19

申请号：US14491813

申请日：2014-09-19

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris ,  Yue Wu

IPC: A61K47/32 ,  A61L31/04 ,  C08F120/56

CPC classification number: C08J5/18 ,  A61K9/0024 ,  A61K47/32 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C08F120/56 ,  C08F220/56 ,  C08F222/1006 ,  C08F222/385 ,  C08J2333/14 ,  C08J2333/26 ,  Y10T428/21

Abstract: Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

Abstract translation: 描述了可生物降解的交联聚合物膜及其制备方法。 聚合物膜可以用于防止手术后和/或递送治疗剂的粘连。