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77 条记录 (耗时 0.03 秒)

    Substituted pyrrole derivatives as cell adhesion inhibitors
    13.
    发明授权
    Substituted pyrrole derivatives as cell adhesion inhibitors 失效
    取代的吡咯衍生物作为细胞粘附抑制剂

    公开(公告)号：US6090841A

    公开(公告)日：2000-07-18

    申请号：US189008

    申请日：1998-11-09

    申请人： Linda Chang ,  Malcolm MacCoss ,  William K. Hagmann

    发明人： Linda Chang ,  Malcolm MacCoss ,  William K. Hagmann

    IPC分类号： C07D207/34 ,  A01N43/36 ,  C07D207/32 ,  C07F9/32

    CPC分类号： C07D207/34

    摘要： Substituted pyrrole derivatives of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

    摘要翻译： 式I的取代的吡咯衍生物是VLA-4和/或α4β7的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病理学。 这些化合物可以配制成药物组合物，并且适用于治疗哮喘，过敏，炎症，多发性硬化以及其它炎性和自身免疫性疾病。

    Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection
    20.
    发明授权
    Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection 失效
    用于治疗RNA依赖性RNA病毒感染的核糖核苷环缩醛衍生物

    公开(公告)号：US07632821B2

    公开(公告)日：2009-12-15

    申请号：US11990051

    申请日：2006-08-04

    申请人： Gabor Butora ,  Kenneth Alan Koeplinger ,  Malcolm MacCoss ,  Daniel R. McMasters ,  David B. Olsen ,  Lihu Yang

    发明人： Gabor Butora ,  Kenneth Alan Koeplinger ,  Malcolm MacCoss ,  Daniel R. McMasters ,  David B. Olsen ,  Lihu Yang

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07H19/06 ,  C07H19/16

    摘要： The present invention provides ribonucleoside 2′,3′-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors of inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors or prodrugs of inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors or prodrugs of inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such ribonucleoside 2′,3′-cyclic acetals alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the ribonucleoside 2′,3′-cyclic acetals of the present invention.

    摘要翻译： 本发明提供结构式I的核糖核苷2'，3'-环状缩醛，其为RNA依赖性RNA病毒聚合酶抑制剂的前体或前药。 这些化合物是RNA依赖性RNA病毒复制的抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体或前药，作为HCV复制抑制剂的前体或前药，和/或用于治疗丙型肝炎感染。 本发明还描述了含有这种核糖核苷2'，3'-环状缩醛单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的药物组合物。 还公开了本发明的核糖核苷2'，3'-环状缩醛的抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。