公开(公告)号：US09072618B2

公开(公告)日：2015-07-07

申请号：US13085718

申请日：2011-04-13

申请人： Thomas Doerr ,  Alexander Borck

发明人： Thomas Doerr ,  Alexander Borck

IPC分类号： A61F2/82 ,  A61L27/52 ,  A61L27/04 ,  A61L27/28 ,  A61L27/50 ,  A61L27/58 ,  A61L31/02 ,  A61L31/08 ,  A61L31/14

CPC分类号： A61F2/82 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2210/0066 ,  A61F2210/009 ,  A61F2250/0001 ,  A61F2250/003 ,  A61L27/04 ,  A61L27/28 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/022 ,  A61L31/08 ,  A61L31/14 ,  A61L31/148

摘要： The present invention relates to a biocorrodable implant in which corrosion may be triggered or accelerated after implantation by applying an external stimulus, the implant having a base body which is completely or partially composed of a biocorrodable metallic material, and the base body having a coating with a protective layer which is not biocorrodable. According to the invention, the implant has control elements which are configured in such a way that the protective layer, optionally in combination with the control elements, completely or partially encloses the base body so as to be impermeable to bodily medium, and the protective layer being convertible to a form which is permeable to bodily medium as the result of a change in shape of the control elements which may be regulated and/or controlled by an external stimulus.

摘要翻译： 本发明涉及一种生物可蚀刻植入物，其中可以通过施加外部刺激在植入后触发或加速腐蚀，所述植入物具有完全或部分由生物可腐蚀金属材料组成的基体，并且所述基体具有涂层 不能生物保护的保护层。 根据本发明，植入物具有控制元件，其配置成使得保护层任选地与控制元件组合，完全或部分地包围基体以便不能渗透到身体介质上，并且保护层 可转换为可由外部刺激调节和/或控制的控制元件的形状变化的结果导致的体内可渗透的形式。

公开(公告)号：US09050456B2

公开(公告)日：2015-06-09

申请号：US13539422

申请日：2012-06-30

申请人： Thomas Doerr

发明人： Thomas Doerr

IPC分类号： A61N1/05 ,  A61N1/39

CPC分类号： A61N1/0563 ,  A61N1/3962

摘要： A unipolar multipurpose electrode line, comprising a line body, a unipolar plug, a defibrillation electrode attached to the line body, and a stimulation and sensing electrode, which are connected by way of a common feed line to the unipolar plug, wherein the defibrillation electrode is connected by means of at least one voltage-dependent component to the electrode feed line so that the connection has low impedance only in response to the application of a defibrillation voltage at the plug.

摘要翻译： 一种单极多用途电极线，包括线体，单极插塞，附着于线体的除颤电极以及通过公共馈电线连接到单极插头的刺激感测电极，其中除颤电极 通过至少一个电压依赖组件连接到电极馈电线，使得连接仅响应于在插塞处施加除颤电压而具有低阻抗。

公开(公告)号：US08965495B2

公开(公告)日：2015-02-24

申请号：US13195560

申请日：2011-08-01

申请人： Thomas Doerr

发明人： Thomas Doerr

IPC分类号： A61B5/04 ,  A61N1/362

CPC分类号： A61N1/3621

摘要： An implantable electronic therapy device, having a therapy unit, a heart rate capturing unit, a contractility determination unit, and an evaluation and control unit. The therapy unit delivers an antitachycardiac therapy. The heart rate capturing unit determines a ventricular heart rate from an input signal, and the contractility determination unit generates from an input signal, a contraction signal reflecting a contractility of a ventricle. The evaluation and control unit is connected to the therapy unit, the heart rate capturing unit, and the contractility determination unit actuates the therapy unit to administer an antitachycardiac therapy when the heart rate capturing unit detects an increase in the heart rate above a specified threshold value and the contractility determination unit supplies a contraction signal which is not physiologically adequate for the increase in the heart rate.

摘要翻译： 一种可植入电子治疗装置，具有治疗单元，心率捕获单元，收缩力确定单元和评估和控制单元。 治疗单位提供抗心律失常疗法。 心率捕获单元从输入信号确定心室心率，并且收缩力确定单元从输入信号产生反映心室收缩力的收缩信号。 评估和控制单元连接到治疗单元，心率捕获单元和收缩力确定单元致动治疗单元以在心率捕获单元检测到心率增加高于指定阈值时进行抗心律失调治疗 并且收缩性判定单元提供在生理上不足以增加心率的收缩信号。

公开(公告)号：US08886305B2

公开(公告)日：2014-11-11

申请号：US12407703

申请日：2009-03-19

申请人： Thomas Doerr ,  Frank Tscherch ,  Ulrich Tietze

发明人： Thomas Doerr ,  Frank Tscherch ,  Ulrich Tietze

IPC分类号： A61N1/05 ,  A61N1/39 ,  A61N1/362 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/3925 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3704 ,  A61N1/3962

摘要： The invention relates to an implantable ventricular heart stimulator (10), comprising an at least partially electrically conductive housing (12), an electrode line terminal for connection of a ventricular defibrillation electrode line (20) and a terminal for a defibrillation electrode (26). According to the invention, the heart stimulator has a far-field electrocardiogram detection unit (70) which has a first input connected to the terminal for the ventricular defibrillation electrode and has a second input connected to the electrically conductive housing and designed or configured to generate a far-field electrocardiogram on the basis of the electric potentials applied to the two inputs during operation. The inventive heart stimulator also has a far-field electrocardiogram evaluation unit (72) which is connected to the far-field electrocardiogram detection unit and is designed to detect signal features characteristic of atrial depolarizations in a far-field electrocardiogram generated by the far-field electrocardiogram detection unit.

摘要翻译： 本发明涉及可植入心室心脏刺激器（10），其包括至少部分导电的壳体（12），用于连接心室除颤电极线（20）和用于除颤电极（26）的端子的电极线端子， 。 根据本发明，心脏刺激器具有远场心电图检测单元（70），其具有连接到心室除颤电极的端子的第一输入端，并且具有连接到导电壳体的第二输入端，并被设计或构造成产生 基于在操作期间施加到两个输入端的电位的远场心电图。 本发明的心脏刺激器还具有远场心电图评估单元（72），其连接到远场心电图检测单元，并被设计成检测由远场产生的远场心电图中心房去极化特征的信号特征 心电图检测单元。

公开(公告)号：US08774919B2

公开(公告)日：2014-07-08

申请号：US13602321

申请日：2012-09-04

申请人： Thomas Doerr ,  Ingo Weiss

发明人： Thomas Doerr ,  Ingo Weiss

IPC分类号： A61M1/12 ,  A61N1/39 ,  A61M1/10 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61M1/1086 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/3331 ,  A61M2230/65 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3956

摘要： A cardiac therapy device having a cardiac assist pump, a defibrillation unit, and a control unit, which is connected to the cardiac assist pump and the defibrillation unit to control them. The cardiac assist pump is implemented in case of use to pump blood from a ventricle into an associated artery and thus relieve the respective ventricle. The defibrillation unit is implemented for automatic defibrillation of a ventricular fibrillation and the control unit is implemented to activate the cardiac assist pump and the defibrillation unit in a coordinated manner in case of a ventricular fibrillation such that the cardiac assist pump first increases its performance to initially cause a pressure relief of at least one assisted ventricle in case of use and the defibrillation unit only subsequently delivers a defibrillation shock, when a ventricular pressure relief is provided.

摘要翻译： 一种具有心脏辅助泵，除颤单元和控制单元的心脏治疗装置，其连接到心脏辅助泵和除颤单元以控制它们。 心脏辅助泵在用于将血液从心室泵送到相关动脉中并因此减轻相应心室的情况下被实施。 除颤单元被实施用于心室颤动的自动除颤，并且控制单元被实现为在心室颤动的情况下以协调的方式激活心脏辅助泵和除颤单元，使得心脏辅助泵首先将其性能提高到最初 在使用情况下导致至少一个辅助心室的压力减轻，并且当提供心室压力释放时，除颤单元仅随后递送除颤电击。

公开(公告)号：US08768430B2

公开(公告)日：2014-07-01

申请号：US12972466

申请日：2010-12-18

申请人： Thomas Doerr ,  Ingo Weiss

发明人： Thomas Doerr ,  Ingo Weiss

IPC分类号： A61B5/103 ,  A61N1/37 ,  A61B5/00 ,  A61B5/11 ,  A61B5/06 ,  G01R33/28

CPC分类号： G01R33/285 ,  A61B5/065 ,  A61B5/103 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7203 ,  A61B2560/029 ,  A61N1/37 ,  A61N1/3718

摘要： Allows the specificity of an automatic MRT detection to be increased in a simple manner. This is achieved using an automatically calibrating position sensor, so that the user does not have to perform additional calibration of this sensor. Incorrect sensor calibrations are thus eliminated as well.

摘要翻译： 允许以简单的方式增加自动MRT检测的特异性。 这是通过使用自动校准位置传感器实现的，因此用户不需要对该传感器进行额外的校准。 因此也消除了不正确的传感器校准。

公开(公告)号：US08676327B2

公开(公告)日：2014-03-18

申请号：US12402821

申请日：2009-03-12

申请人： Thomas Doerr ,  Ingo Weiss ,  Andreas Neumann

发明人： Thomas Doerr ,  Ingo Weiss ,  Andreas Neumann

IPC分类号： A61N1/00

CPC分类号： A61B5/6864 ,  A61B5/02405 ,  A61B5/0452 ,  A61B2562/0219 ,  A61N1/36082

摘要： Neurostimulator (20) comprising a signal generator (40) for generating stimulation pulses, connected or connectable to at least one electrode (10) implantable in the brain of a patient, comprising a signal generator control unit (36) connected to the signal generator (40) and designed to control the delivery of stimulation pulses and to make adjustments in signal generator settings as needed, comprising a device connected to the signal generator control unit (36) for determination and analysis of the heart rate of a patient (30, 32, 34), characterized in that the signal generator control unit (36) is designed to check on the health status of a patient and/or the success of a treatment using at least one heart-rate-dependent characteristic quantity determined by the device for determination and analysis of the heart rate (30, 32, 34) and to make an adjustment in the signal generator settings if necessary.

摘要翻译： 神经刺激器（20），包括用于产生刺激脉冲的信号发生器（40），所述刺激脉冲连接或连接到可植入患者脑部的至少一个电极（10），包括连接到所述信号发生器的信号发生器控制单元（36） 40），并且被设计成控制刺激脉冲的传送并且根据需要进行信号发生器设置的调整，包括连接到信号发生器控制单元（36）的装置，用于确定和分析患者的心率（30,32 ，34），其特征在于，所述信号发生器控制单元（36）设计成使用由所述装置确定的至少一个基于心率的特征量来检查患者的健康状况和/或治疗成功 确定和分析心率（30,32,34），并在必要时进行信号发生器设置的调整。

公开(公告)号：US08428721B2

公开(公告)日：2013-04-23

申请号：US12627004

申请日：2009-11-30

申请人： Thomas Doerr

发明人： Thomas Doerr

IPC分类号： A61N1/00

CPC分类号： A61N1/3752 ,  A61N1/05 ,  A61N1/37241

摘要： An adapter for temporary sterile electric connection of an implantable medical electronic device to an electrode line that is to be connected to the implantable medical electronic device during implantation for undistorted transmission of measured values detectable on the electrode line to the device.

摘要翻译： 一种用于将植入式医疗电子设备临时无菌电连接到电极线的适配器，该电极线将在植入期间连接到可植入医疗电子设备，用于在电极线上可检测的测量值的未失真传输到设备。

公开(公告)号：US07833191B2

公开(公告)日：2010-11-16

申请号：US12401989

申请日：2009-03-11

申请人： Erhard Flach ,  Thomas Doerr

发明人： Erhard Flach ,  Thomas Doerr

IPC分类号： A61M31/00

CPC分类号： A61N1/0534 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/0158

摘要： Controllable catheter (10) having an elongated shaft (13) which is subdivided into multiple shaft segments, at least two of which are designed as tilt segments (12) and are each connected to at least one adjustment device, so that they can be tilted about a desired tilt angle with respect to the longitudinal axis of the shaft (13), wherein each of the at least one adjustment device is individually controllable and allows individual tilting of a corresponding tilt segment about a desired tilt angle.

摘要翻译： 可控导管（10）具有细长轴（13），细长轴（13）被细分为多个轴段，其至少两个被设计为倾斜段（12），并且各自连接到至少一个调节装置，使得它们可以倾斜 围绕关于轴（13）的纵向轴线的期望的倾斜角度，其中所述至少一个调节装置中的每一个都是单独可控的，并且允许相应的倾斜段围绕期望的倾斜角度单独倾斜。

公开(公告)号：US20090306731A1

公开(公告)日：2009-12-10

申请号：US12475629

申请日：2009-06-01

申请人： Thomas Doerr

发明人： Thomas Doerr

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3702 ,  A61N1/3925 ,  A61N1/395

摘要： An implantable cardiac stimulator includes a cardioversion/defibrillation unit connected to at least one electrode pair for generation and delivery of cardioversion or defibrillation shocks; an atrial sensing unit detecting atrial contraction, and outputting an atrial sensing signal indicating a atrial event when an atrial contraction is detected; a ventricular sensing unit detecting ventricular contraction, and outputting a ventricular sensing signal when a ventricular contraction is detected; a tachycardia detection unit connected to the atrial and ventricular sensing units and detecting a tachycardia, and classifying it as a ventricular tachycardia (VT) or as a supraventricular tachycardia (SVT); and a treatment control unit designed to trigger at least one atrial cardioversion shock when a ventricular rhythm detected by the ventricular sensing unit is faster than a programmed frequency limit, and the tachycardia detection unit classifies an SVT as an atrial fibrillation (AFib).

摘要翻译： 植入式心脏刺激器包括与至少一个电极对连接的心脏复律/除颤单元，用于产生和递送心脏复律或除颤电击; 心房感知单元检测心房收缩，并且当检测到心房收缩时输出指示心房事件的心房感测信号; 检测心室收缩的心室感测单元，并且当检测到心室收缩时输出心室感测信号; 连接到心房和心室感测单元并检测心动过速并将其分类为室性心动过速（VT）或作为室上性心动过速（SVT）的心动过速检测单元; 以及治疗控制单元，其被设计成当由心室感测单元检测到的心室节律快于编程频率极限时触发至少一个心房复律冲击，并且心动过速检测单元将SVT分类为心房颤动（AFib）。