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公开(公告)号：US20090314414A1
公开(公告)日：2009-12-24
申请号：US12522609
申请日：2008-01-11
IPC分类号： B32B37/02
CPC分类号： G03F7/0002 , B05D1/28 , B82Y10/00 , B82Y40/00 , Y10S438/973 , Y10S438/976
摘要： The invention relates to a method for contacting a flexible sheet to a first element with improved lateral alignment. The method includes a step of measuring a first lateral misalignment after establishing a first contact between the flexible sheet and either of the first element and a sheet parking surface called anchor in the first stage. If the 5 misalignment exceeds a predetermined threshold the flexible sheet is parked at the anchor such that it is not in contact with the first element, and the relative position of the first element and the anchor is altered during the second stage for correcting the mismatch during a contact between the flexible sheet and the first element to be established within the next step of the method. During the steps of shifting the contact point to obtain the second stage 10 the contacting process is more accurate and reproducible than the process for establishing the initial contact. The invention also relates to an apparatus for executing the method, and the use of the method and apparatus for the manufacture of devices.
摘要翻译： 本发明涉及一种使柔性片与第一元件接触的方法，该方法具有改进的横向对准。 该方法包括在第一阶段中建立柔性片与第一元件中的任一个和称为锚的片材停车面之间的第一接触之后，测量第一侧向偏移的步骤。 如果5个未对准超过预定阈值，则柔性片材停放在锚固件处，使得其不与第一元件接触，并且在第二阶段期间改变第一元件和锚的相对位置以纠正不匹配 在该方法的下一步骤中在柔性片和要建立的第一元件之间的接触。 在移动接触点以获得第二阶段10的步骤期间，接触过程比用于建立初始接触的过程更准确和可再现。 本发明还涉及一种用于执行该方法的装置，以及用于制造装置的方法和装置的使用。
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公开(公告)号：US07106519B2
公开(公告)日：2006-09-12
申请号：US10631996
申请日：2003-07-31
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US10743836B2
公开(公告)日：2020-08-18
申请号：US13393857
申请日：2010-09-15
申请人： Mischa Megens , Jan Suijver
发明人： Mischa Megens , Jan Suijver
IPC分类号： A61B8/00 , A61B8/08 , G01K13/00 , G01K11/24 , A61B18/14 , A61B8/12 , A61B18/00 , A61N7/00 , A61B18/12 , A61B90/00
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end, a distal end (10) and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The controller unit detects the acoustic path length through the transmission element and determines the temperature at the distal end from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.
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公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译： 用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器 信号。 评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。 在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。 在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。
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公开(公告)号：US08655184B2
公开(公告)日：2014-02-18
申请号：US12993264
申请日：2009-05-20
IPC分类号： H04B10/12
CPC分类号： G02B5/00 , G02B5/04 , G02B27/095 , G02B2207/117 , H01S3/0057
摘要： The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (P1, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost-effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.
摘要翻译： 本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如， 一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。 补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散 。 本发明有利于获得相对简单的构造和使用的高阶色散补偿装置，使其成为一种相当具有成本效益的装置。 本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。 在多光子成像系统中。
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公开(公告)号：US20100259254A1
公开(公告)日：2010-10-14
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).
摘要翻译： 本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。 通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。 然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于 这个传感器信号。 在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。 在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。 此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。
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公开(公告)号：US07297474B2
公开(公告)日：2007-11-20
申请号：US11457243
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B3/00
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US08828740B2
公开(公告)日：2014-09-09
申请号：US11814826
申请日：2006-01-30
申请人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
发明人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
IPC分类号： G01N33/553 , G01N27/74 , G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and includes at least one sensor element (23) for detecting the presence of magnetic particles (13), an element or elements for attracting magnetic structures having at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and an element or elements for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并且包括用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于 吸引具有至少一个磁性颗粒（13）的磁性结构朝向和传递到传感器装置（15）的结合表面（40）上，以及用于重新排列和随机化各个磁性颗粒（13）的位置的元件或元件， 相对于结合表面（40）上的结合位点以在所有单个颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。
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公开(公告)号：US20130004982A1
公开(公告)日：2013-01-03
申请号：US13172070
申请日：2011-06-29
申请人： Ludwig Bär , Oliver Hayden , Michael Johannes Helou , Mischa Megens , Mathias Reisbeck , Manfred Rührig , Sandro Francesco Tedde
发明人： Ludwig Bär , Oliver Hayden , Michael Johannes Helou , Mischa Megens , Mathias Reisbeck , Manfred Rührig , Sandro Francesco Tedde
CPC分类号： G01N33/587 , G01N15/1031 , G01N2015/1062
摘要： A magnetic flow cytometry apparatus for detection of cells labeled with magnetic nanoparticles has at least one pair of oppositely oriented magnets to provide between the magnets a first magnetic field region with a low magnetic field strength and to provide at poles of the magnets second magnetic field regions with a high magnetic field strength. The magnetic labeled cells provided within a flow input into the magnetic flow cytometry apparatus are enriched in at least one of the second magnetic field regions and supplied to the first magnetic field region, where a magnetic field is applied to the enriched magnetic labeled cells to measure the magnetic relaxation of the magnetic labeled cells in response to the applied magnetic field.
摘要翻译： 用于检测用磁性纳米颗粒标记的细胞的磁流式细胞仪装置具有至少一对相反方向的磁体，以在磁体之间提供具有低磁场强度的第一磁场区域，并且在磁体的极点处提供第二磁场区域 具有高磁场强度。 提供在输入到磁流式细胞计量装置的流量内的磁性标记细胞富集在第二磁场区域中的至少一个中，并被提供给第一磁场区域，其中向富集的磁性标记细胞施加磁场以测量 响应于施加的磁场，磁性标记的细胞的磁弛豫。
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公开(公告)号：US20120165666A1
公开(公告)日：2012-06-28
申请号：US13393857
申请日：2010-09-15
申请人： Mischa Megens , Jan Suijver
发明人： Mischa Megens , Jan Suijver
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end, a distal end (10) and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The controller unit detects the acoustic path length through the transmission element and determines the temperature at the distal end from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.
摘要翻译： 公开了一种医用超声波装置。 该装置包括具有近端，远端（10）和远端区域（1）的细长主体。 用于产生声辐射的一个或多个超声换能器（4）位于细长体内的远端区域。 对声辐射基本透明的传输元件（5）位于声辐射的辐射路径中，并且控制器单元可操作地连接到超声换能器。 控制器单元通过传输元件检测声路长度，并根据检测到的声道长度确定远端处的温度。 在一个实施例中，医疗装置是超声RF消融导管。
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