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公开(公告)号：US20130004982A1
公开(公告)日：2013-01-03
申请号：US13172070
申请日：2011-06-29
申请人： Ludwig Bär , Oliver Hayden , Michael Johannes Helou , Mischa Megens , Mathias Reisbeck , Manfred Rührig , Sandro Francesco Tedde
发明人： Ludwig Bär , Oliver Hayden , Michael Johannes Helou , Mischa Megens , Mathias Reisbeck , Manfred Rührig , Sandro Francesco Tedde
CPC分类号： G01N33/587 , G01N15/1031 , G01N2015/1062
摘要： A magnetic flow cytometry apparatus for detection of cells labeled with magnetic nanoparticles has at least one pair of oppositely oriented magnets to provide between the magnets a first magnetic field region with a low magnetic field strength and to provide at poles of the magnets second magnetic field regions with a high magnetic field strength. The magnetic labeled cells provided within a flow input into the magnetic flow cytometry apparatus are enriched in at least one of the second magnetic field regions and supplied to the first magnetic field region, where a magnetic field is applied to the enriched magnetic labeled cells to measure the magnetic relaxation of the magnetic labeled cells in response to the applied magnetic field.
摘要翻译： 用于检测用磁性纳米颗粒标记的细胞的磁流式细胞仪装置具有至少一对相反方向的磁体，以在磁体之间提供具有低磁场强度的第一磁场区域，并且在磁体的极点处提供第二磁场区域 具有高磁场强度。 提供在输入到磁流式细胞计量装置的流量内的磁性标记细胞富集在第二磁场区域中的至少一个中，并被提供给第一磁场区域，其中向富集的磁性标记细胞施加磁场以测量 响应于施加的磁场，磁性标记的细胞的磁弛豫。
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公开(公告)号：US07892817B2
公开(公告)日：2011-02-22
申请号：US11569084
申请日：2005-05-13
申请人： Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
发明人： Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： C12M3/00
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y25/00 , G01N27/745
摘要： A method and a device are provided for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle is attached to the surface. The method and device may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor combines in one sensor the detection of magnetic particles or labels and determination of the binding quality and the properties of magnetic particles or labels which are bound to the surface of another entity.
摘要翻译： 提供了一种方法和装置，用于通过施加磁场和检测与磁性纳米颗粒旋转或运动自由相关的物理参数来区分特定结合与至少一个磁性纳米颗粒与另一个实体的表面之间的较小特异性结合，同时磁性 纳米颗粒附着在表面。 该方法和装置可以应用于体内和体外生物分子诊断。 该传感器将一个传感器结合在一起，检测磁性颗粒或标签，并确定结合质量以及结合到另一个实体表面的磁性颗粒或标签的性质。
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公开(公告)号：US20100083855A1
公开(公告)日：2010-04-08
申请号：US12517251
申请日：2007-12-03
IPC分类号： B41F31/00
CPC分类号： B05D1/28 , B05C1/027 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The invention provides a method and apparatus for laminating a sheet to a substrate in a stress free and distortion-less manner. The method comprises providing the sheet and substrate such that an attractive force between them exists that is capable of bringing the sheet and surface together at least when their distance is shorter than a critical distance. The method creates these conditions by locally making an initial contact between the sheet and substrate such that at a contact front, being the boundary between areas where the substrate and sheet are in contact and those where they are not in contact, these conditions exist. In a further step the sheet and substrate are allowed to gradually make contact such that the contact front advances along either of the substrate or sheet surface therewith increasing the contacting area between the substrate and the sheet. The method is advantages when used during imprint lithography or embossing processes or other processes where feature patterns need to be transferred from the substrate to the surface or vice versa.
摘要翻译： 本发明提供了一种以无应力和无失真的方式将片层压到基片上的方法和装置。 该方法包括提供片材和基底，使得它们之间的吸引力存在，其能够至少当其距离短于临界距离时将片材和表面组合在一起。 该方法通过局部地在片材和衬底之间进行初始接触而产生这些条件，使得在作为衬底和片材接触的区域与未接触的区域之间的边界的接触面处存在这些条件。 在另外的步骤中，允许片材和基底逐渐接触，使得接触前端沿着基底或片材表面前进，从而增加基底和片材之间的接触面积。 该方法是在压印光刻或压花加工或特征图案需要从基底转移到表面或反之亦然的其它过程中使用时的优点。
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公开(公告)号：US20060245065A1
公开(公告)日：2006-11-02
申请号：US11457187
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
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公开(公告)号：US20080191688A1
公开(公告)日：2008-08-14
申请号：US11814826
申请日：2006-01-30
申请人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
发明人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
IPC分类号： G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并包括：用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引磁性颗粒 包括朝向和传递到传感器装置（15）的结合表面（40）上的至少一个磁性颗粒（13）的结构，以及用于重新排列和随机化各个磁性颗粒（13）相对于结合位点 在结合表面（40）上以在所有单独的颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。
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公开(公告)号：US20060245066A1
公开(公告)日：2006-11-02
申请号：US11457243
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US09808323B2
公开(公告)日：2017-11-07
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display (10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
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公开(公告)号：US09440254B2
公开(公告)日：2016-09-13
申请号：US12517251
申请日：2007-12-03
CPC分类号： B05D1/28 , B05C1/027 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The invention provides a method and apparatus for laminating a sheet to a substrate in a stress free and distortion-less manner. The method comprises providing the sheet and substrate such that an attractive force between them exists that is capable of bringing the sheet and surface together at least when their distance is shorter than a critical distance. The method creates these conditions by locally making an initial contact between the sheet and substrate such that at a contact front, being the boundary between areas where the substrate and sheet are in contact and those where they are not in contact, these conditions exist. In a further step the sheet and substrate are allowed to gradually make contact such that the contact front advances along either of the substrate or sheet surface therewith increasing the contacting area between the substrate and the sheet. The method is advantages when used during imprint lithography or embossing processes or other processes where feature patterns need to be transferred from the substrate to the surface or vice versa.
摘要翻译： 本发明提供了一种以无应力和无失真的方式将片层压到基片上的方法和装置。 该方法包括提供片材和基底，使得它们之间的吸引力存在，其能够至少当其距离短于临界距离时将片材和表面组合在一起。 该方法通过局部地在片材和基底之间进行初始接触而产生这些条件，使得在作为基底和片材接触的区域与不接触的区域之间的边界的接触面处存在这些条件。 在另外的步骤中，允许片材和基底逐渐接触，使得接触前端沿着基底或片材表面前进，从而增加基底和片材之间的接触面积。 该方法是在压印光刻或压花加工或特征图案需要从基底转移到表面或反之亦然的其它过程中使用时的优点。
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公开(公告)号：US08172968B2
公开(公告)日：2012-05-08
申请号：US12522609
申请日：2008-01-11
IPC分类号： B32B41/00
CPC分类号： G03F7/0002 , B05D1/28 , B82Y10/00 , B82Y40/00 , Y10S438/973 , Y10S438/976
摘要： The invention relates to a method for contacting a flexible sheet to a first element with improved lateral alignment. The method includes a step of measuring a first lateral misalignment after establishing a first contact between the flexible sheet and either of the first element and a sheet parking surface called anchor in the first stage. If the 5 misalignment exceeds a predetermined threshold the flexible sheet is parked at the anchor such that it is not in contact with the first element, and the relative position of the first element and the anchor is altered during the second stage for correcting the mismatch during a contact between the flexible sheet and the first element to be established within the next step of the method. During the steps of shifting the contact point to obtain the second stage 10 the contacting process is more accurate and reproducible than the process for establishing the initial contact. The invention also relates to an apparatus for executing the method, and the use of the method and apparatus for the manufacture of devices.
摘要翻译： 本发明涉及一种使柔性片与第一元件接触的方法，该方法具有改进的横向对准。 该方法包括在第一阶段中建立柔性片与第一元件中的任一个和称为锚的片材停车面之间的第一接触之后，测量第一侧向偏移的步骤。 如果5个未对准超过预定阈值，则柔性片材停放在锚固件处，使得其不与第一元件接触，并且在第二阶段期间改变第一元件和锚的相对位置以纠正不匹配 在该方法的下一步骤中在柔性片和要建立的第一元件之间的接触。 在移动接触点以获得第二阶段10的步骤期间，接触过程比用于建立初始接触的过程更准确和可再现。 本发明还涉及一种用于执行该方法的装置，以及用于制造装置的方法和装置的使用。
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公开(公告)号：US20120105480A1
公开(公告)日：2012-05-03
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
IPC分类号： G09G5/00
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display(10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
摘要翻译： 本发明涉及一种可视化装置，用于将能量施加到物体的质量。 基于a）所提供的对象图像和b）提供的质量值，表示在物体上的位置处对物体施加能量的质量（3），可视化对象（3）上的位置处的能量的质量 ），其中，视觉特性分配单元（9）根据所述质量值向所述位置分配视觉特性，并且显示器（10）在所述图像中所示的对象的位置处显示所提供的图像和所分配的视觉特性。 通常，将能量施加到物体的人集中在施加能量的位置上。 由于质量信息显示在人已经聚焦的位置，所以质量依赖信息可以容易地被人吸收。
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