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37 条记录 (耗时 0.034 秒)

    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes
    11.
    发明授权
    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes 失效
    药理活性的O-酰基-2,3-二芳基-3-卤代丙烯酰基肟

    公开(公告)号：US4056629A

    公开(公告)日：1977-11-01

    申请号：US716277

    申请日：1976-08-20

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    IPC分类号： A61K20060101 ,  A61K31/15 ,  A61K31/215 ,  A61K31/27 ,  C07C20060101

    CPC分类号： C07D417/04

    摘要： A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

    摘要翻译： 由式I（I）的O-酰基-2,3-二芳基-3-卤代 - 丙烯醛肟组成或含有其中X表示氯或溴原子的药​​物，R代表烷基，烯基， 或具有1至12个碳原子的芳基，芳氧基，芳基烷基，芳基烷氧基，芳基氨基或芳基烷基氨基，任选地被1或2个具有1至6个碳原子的烷基取代的烷氧基，链烯氧基或烷基氨基， R2，R3和R4相同或不同，各自表示氢原子，卤素原子或具有1至6个碳原子的烷基或烷氧基，其制备方法和治疗嘌呤病症的方法 代谢。

    Lowering lipid and sugar levels in the blood with a bis(4-hydroxyphenyl)alkanoic acid or ester thereof
    18.
    发明授权
    Lowering lipid and sugar levels in the blood with a bis(4-hydroxyphenyl)alkanoic acid or ester thereof 失效
    用双（4-羟基苯基）链烷酸或其酯降低血液中的脂质和糖含量

    公开(公告)号：US4007282A

    公开(公告)日：1977-02-08

    申请号：US367887

    申请日：1973-06-07

    申请人： Otto Mauz ,  Ernold Granzer

    发明人： Otto Mauz ,  Ernold Granzer

    IPC分类号： C07C59/52 ,  A61K31/19 ,  A61K31/215

    CPC分类号： C07C59/52

    摘要： Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II ##STR1## wherein R.sup.1 and R.sup.2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R.sup.4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula ##STR2## in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R.sup.6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

    摘要翻译： 作用于代谢的药物组合物，其含有对应于式I和II的活性物质双（4-羟基 - 苯基）链烷酸，其中R 1和R 2可以相同或不同，各代表氢 或卤素原子或碳原子数1〜4的烷基，R3表示氢原子或碳原子数1〜3的烷基，R4表示羟基，碳原子数1〜18的烷氧基，苯基 - 烷氧基，具有1〜 4个烷基碳原子，具有5至8个碳原子的环烷氧基或式“IMAGE”的基团，其中可以相同或不同的Z和Z'各自代表氢，1至18个碳原子的烷基，苯基或 5〜8个碳原子的环烷基，或者与氮原子一起形成杂环，R6表示2〜12个原子的亚烷基，n表示0或1〜6的整数，其制备方法 。

    Imidazolyl-(2)-carbinols having hypolipidemic action and process for preparing them
    19.
    发明授权
    Imidazolyl-(2)-carbinols having hypolipidemic action and process for preparing them 失效
    具有降血脂作用的咪唑基 - （2） - 甲醇及其制备方法

    公开(公告)号：US4213994A

    公开(公告)日：1980-07-22

    申请号：US6203

    申请日：1979-01-24

    申请人： Ulrich Gebert ,  Ernold Granzer

    发明人： Ulrich Gebert ,  Ernold Granzer

    IPC分类号： C07D233/54 ,  C07D233/64 ,  C07D235/12 ,  C07D235/18 ,  C07D235/20 ,  A61K31/415

    CPC分类号： C07D233/64 ,  C07D235/12 ,  C07D235/18 ,  C07D235/20 ,  C07C2103/18

    摘要： Pharmaceutical preparations having hypolipidemic activity, which contain in addition to a pharmaceutically acceptable carrier an effective amount of an imidazolyl-(2)-carbinol of the general formula I ##STR1## in which R represents hydrogen, lower alkyl, phenyl or benzyl, R.sub.1 and R.sub.2 each represent hydrogen or together the group --CH.dbd.CH--CH.dbd.CH--, R.sub.3 and R.sub.4 represent hydrogen, lower alkyl, phenyl, lower haloalkyl, lower alkylphenyl, lower alkoxyphenyl, lower haloalkoxyphenyl, mono- or dihalophenyl, imidazolyl or benzylimidazolyl or R.sub.3 and R.sub.4 are together fluoryl of the formula ##STR2## or of a physiologically tolerable acid addition salt thereof, and process for preparing them.

    摘要翻译： 含有降血脂活性的药物制剂，除了药学上可接受的载体之外还含有有效量的通式I（I）的咪唑基 - （2） - 甲醇，其中R表示氢，低级烷基，苯基或苄基 ，R1和R2各自表示氢或基团-CH = CH-CH = CH-，R3和R4表示氢，低级烷基，苯基，低级卤代烷基，低级烷基苯基，低级烷氧基苯基，低级卤代烷氧基苯基，单或二卤代苯基，咪唑基 或苄基咪唑基或R3和R4一起是式“IMAGE”的氟基或其生理上可耐受的酸加成盐，以及其制备方法。