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公开(公告)号:US06593357B1
公开(公告)日:2003-07-15
申请号:US10225719
申请日:2002-08-22
申请人: Jeremy Green , Jingrong Cao , Michael Hale , Christopher Baker , Francois Maltais , James Janetka , Michael Mullican , Guy Bemis , Xiaoling Xie , Judith Straub , Qing Tang
发明人: Jeremy Green , Jingrong Cao , Michael Hale , Christopher Baker , Francois Maltais , James Janetka , Michael Mullican , Guy Bemis , Xiaoling Xie , Judith Straub , Qing Tang
IPC分类号: A61K314155
CPC分类号: C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
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公开(公告)号:US07253187B2
公开(公告)日:2007-08-07
申请号:US10770814
申请日:2004-02-03
申请人: Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov
发明人: Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov
IPC分类号: C07D401/04 , A61K31/4427
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14
摘要: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
摘要翻译: 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物:其中Z 1和Z 2各自独立地为氮或CH并且环A,T m 第二,第二,第二,第三,第三和第三,第二,如 规范。 该化合物特别可用作ERK2的抑制剂,并且用于治疗由蛋白激酶抑制剂,特别是癌症,炎性疾病,再狭窄,糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。
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公开(公告)号:US07056944B2
公开(公告)日:2006-06-06
申请号:US10688613
申请日:2003-10-17
申请人: Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
发明人: Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
IPC分类号: A61K31/40 , C07D207/00
CPC分类号: C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译: 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物:其中R 1-4,Q和T在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂,特别是癌症,炎症性疾病,再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。
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公开(公告)号:US06699865B2
公开(公告)日:2004-03-02
申请号:US10335793
申请日:2003-01-02
申请人: Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang
发明人: Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang
IPC分类号: A61K314155
CPC分类号: C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译: 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物:其中R 1-4,Q和T在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂,特别是癌症,炎症性疾病,再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。
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公开(公告)号:US06743791B2
公开(公告)日:2004-06-01
申请号:US10071699
申请日:2002-02-08
申请人: Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov
发明人: Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov
IPC分类号: C07D40304
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14
摘要: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
摘要翻译: 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物:其中Z 1和Z 2各自独立地为氮或CH,环A,TmR 1,Q 2,R un R 3, 和Sp如说明书中所述。 该化合物特别可用作ERK2的抑制剂,并且用于治疗由蛋白激酶抑制剂,特别是癌症,炎性疾病,再狭窄,糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。
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公开(公告)号:US08357102B2
公开(公告)日:2013-01-22
申请号:US12746171
申请日:2008-12-05
申请人: Fan-Gang Zeng , Qing Tang , Jeffrey Alan Carroll
发明人: Fan-Gang Zeng , Qing Tang , Jeffrey Alan Carroll
IPC分类号: A61B5/00
CPC分类号: A61B5/128 , A61M21/00 , A61M2021/0027 , A61N1/36036 , H04R25/75
摘要: Methods and devices for treating tinnitus in human or animal subjects wherein the subject is caused to perceive a tinnitus suppressing sound which fully or partially suppresses the subject's tinnitus. In some embodiments of this method, the subject selects a sound that he or she perceives to be the same as the tinnitus and that sound (or a similar sound that is complementary to the subject's perceived tinnitus) is then used as the tinnitus suppressing sound. In other embodiments, the tinnitus suppressing may be a sound that has previously been determined to suppress tinnitus in a substantial number of subjects.
摘要翻译: 用于治疗人或动物受试者的耳鸣的方法和装置,其中使受试者感知到完全或部分抑制受试者的耳鸣的耳鸣抑制声音。 在该方法的一些实施例中,对象选择他或她感觉与耳鸣相同的声音,然后将该声音(或与被摄体感知到的耳鸣互补的类似声音)用作耳鸣抑制声音。 在其他实施例中,耳鸣抑制可以是先前已被确定为在大量受试者中抑制耳鸣的声音。
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公开(公告)号:US20110182856A1
公开(公告)日:2011-07-28
申请号:US13074772
申请日:2011-03-29
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Amaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Amaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/424 , C07D498/10 , A61K31/4439 , A61K31/497 , A61K31/5377 , A61K39/00 , A61K38/21 , A61K31/7056 , A61K31/7072 , A61K31/427 , A61P37/02 , A61P31/12 , A61P31/14 , C12N9/99
CPC分类号: C07D498/10
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶,特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号:US07964624B1
公开(公告)日:2011-06-21
申请号:US11711845
申请日:2007-02-27
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4725 , C07D498/10 , C07D261/04 , C07D413/04
CPC分类号: C07D498/10
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶,特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号:US5572449A
公开(公告)日:1996-11-05
申请号:US245865
申请日:1994-05-19
申请人: Qing Tang , Wei-Ping Wang , Zhongxue Gan , Ruiming Zhang , John Moh
发明人: Qing Tang , Wei-Ping Wang , Zhongxue Gan , Ruiming Zhang , John Moh
CPC分类号: B60T7/22 , B60K31/0008 , B60W2550/402 , G01S2013/9321
摘要: An automatic vehicle following system is provided for controlling a following vehicle to maintain at least a predetermined distance behind a preceding vehicle and to substantially follow the path of the preceding vehicle. An on-line measurement system of the preceding vehicle generates signals indicative of the velocity (having speed and directional components) of the preceding vehicle, and a communication system transmits the velocity signals to the following vehicle. The following vehicle likewise has a communication system for receiving the signals from the preceding vehicle, and an on-line measurement system for providing signals indicative of the velocity of the following vehicle and signals indicative of the distance between the two vehicles. A signal processing system of the following vehicle is coupled to the communication system and on-line measurement system for estimating motion trajectory of the preceding vehicle based on the difference in the velocities of the preceding and following vehicles and the following distance. A control system generates control signals and takes action so as to perform speed control and maintain at least a predetermined safe following distance between the two vehicles, and steering control to substantially follow the path of the preceding vehicle.
摘要翻译: 提供了一种自动车辆跟随系统,用于控制后续车辆至少保持在前一车辆后面的预定距离并且基本上跟随前方车辆的路径。 前一车辆的在线测量系统产生指示前一车辆的速度(具有速度和方向分量)的信号,并且通信系统将速度信号发送到随后的车辆。 以下车辆同样具有用于接收来自前一车辆的信号的通信系统和用于提供表示随后车辆的速度的信号的在线测量系统以及指示两车辆之间的距离的信号。 以下车辆的信号处理系统耦合到通信系统和在线测量系统,用于基于前一车辆和后续车辆的速度的差异以及随后的距离来估计前一车辆的运动轨迹。 控制系统产生控制信号并采取动作以便执行速度控制并且保持两辆车辆之间至少预定的安全跟随距离,并且转向控制基本上跟随前方车辆的路径。
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公开(公告)号:US09778719B2
公开(公告)日:2017-10-03
申请号:US13695403
申请日:2011-04-29
申请人: Zhongxue Gan , Binshen Meng , Zhengjian Liu , An Wei , Qing Tang , Fan Zhang
发明人: Zhongxue Gan , Binshen Meng , Zhengjian Liu , An Wei , Qing Tang , Fan Zhang
CPC分类号: G06F1/3203 , G06Q10/04 , G06Q50/06
摘要: There discloses a ubiquitous energy network for optimum utilization of energy, which includes nodes connected by an interconnected network architecture of virtual pipelines transferring a ubiquitous energy flow, with the ubiquitous energy flow being transferred among the nodes bi-directionally. The node includes a system energy efficiency controller, and at least one of other nodes, an energy generation device, an energy storage device, an energy utilization device, and an energy regeneration device connected to the controller. The controller controls the input and output of the ubiquitous energy flow of the at least one of the other nodes, the energy generation device, the energy storage device, the energy utilization device, the energy regeneration device. Furthermore, the node, an access terminal, a virtual tag, and the virtual pipeline of the ubiquitous energy network, and a server and method for providing energy transaction and service by the ubiquitous energy network are disclosed.
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