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33 条记录 (耗时 0.026 秒)

    Methods for detecting nucleic acid sequence variation
    13.
    发明授权
    Methods for detecting nucleic acid sequence variation 有权
    核酸序列变异检测方法

    公开(公告)号：US07273699B2

    公开(公告)日：2007-09-25

    申请号：US10206561

    申请日：2002-07-25

    申请人： Robert H. Lipsky ,  Chiara Mazzanti ,  David Goldman

    发明人： Robert H. Lipsky ,  Chiara Mazzanti ,  David Goldman

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6827 ,  C12Q2527/107 ,  C12Q2527/113

    摘要： Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.

    摘要翻译： 通过检测多个核酸的融合谱之间或之间的差异来检测序列变异，例如多态性。 通过在一段时间内在温度变化期间观察核酸来产生熔融曲线。 如果将核酸稀释成用于分析的溶液，则溶液之间或之间的核酸浓度可以基本上相同。 融合谱和序列变异可用于鉴定野生型核酸序列的变化，如单核苷酸多态性（SNP），小插入或缺失或小反转。

    Method of treating otitis with ciprofloxacin-hydrocortisone suspension
    14.
    发明授权
    Method of treating otitis with ciprofloxacin-hydrocortisone suspension 失效
    用环丙沙星 - 氢化可的松悬浮液治疗中耳炎的方法

    公开(公告)号：US5843930A

    公开(公告)日：1998-12-01

    申请号：US838473

    申请日：1997-04-07

    申请人： Shivaji Purwar ,  David Goldman

    发明人： Shivaji Purwar ,  David Goldman

    IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K31/57 ,  A61K47/32 ,  A61K31/495 ,  A61K31/56

    CPC分类号： A61K9/0046 ,  A61K31/57 ,  A61K47/32 ,  A61K9/10

    摘要： The invention is directed to a method of treating otitis which comprises introducing an antibacterially-effective amount of a composition comprising a non-ototoxic, topical, otic pharmaceutic composition comprising (a) ciprofloxacin in aqueous solution in an amount effective for antibacterial action; (b) a non-ionic viscosity augmenter unaffected by pH and ionic level, said viscosity augmenter being present in an amount effective for augmenting viscosity of the composition to a viscosity greater than that of water, said viscosity augmenter being at least 85% hydrolyzed polyvinyl alcohol; (c) a non-ototoxic preservative present in an amount effective for antibacterial action, the preservative being benzyl alcohol; (d) water sufficient to produce an aqueous composition; (e) hydrocortisone in aqueous suspension in an amount effective for anti-inflammatory action; (f) lecithin in an amount effective for enhancing suspension of other constituents in the composition; and (g) polysorbate ranging from polysorbate 20 to 80 in an amount effective for spreading the preparation on a hydrophobic skin surface to the site of infection or inflammation.

    摘要翻译： 本发明涉及一种治疗耳炎的方法，其包括引入抗菌有效量的包含非耳毒性，局部，耳用药物组合物的组合物，其包含（a）环丙沙星在水溶液中，其量为有效抗菌作用的量; （b）不受pH和离子水平影响的非离子粘度增强剂，所述粘度增加剂以有效增加组合物粘度至粘度大于水的粘度的量存在，所述粘度增加剂为至少85％的水解聚乙烯 醇; （c）以有效抗菌作用的量存在的非耳毒性防腐剂，该防腐剂为苄醇; （d）足以产生含水组合物的水; （e）水性悬浮液中的氢化可的松，其量为有效抗炎作用的量; （f）卵磷脂，其用量有效地增强组合物中其他成分的悬浮液; 和（g）范围从聚山梨酸酯20至80的聚山梨醇酯，其量有效地将制剂铺展在疏水性皮肤表面至感染或炎症部位。

    REMOTELY CONTROLLING ASPECTS OF POOLS AND SPAS
    17.
    发明申请
    REMOTELY CONTROLLING ASPECTS OF POOLS AND SPAS 审中-公开
    远程控制池和SPAS的方面

    公开(公告)号：US20140064139A1

    公开(公告)日：2014-03-06

    申请号：US13600567

    申请日：2012-08-31

    申请人： E. Keith Mcqueen ,  David Nibler ,  Dindo Uy ,  David Goldman

    发明人： E. Keith Mcqueen ,  David Nibler ,  Dindo Uy ,  David Goldman

    IPC分类号： H04W84/12

    CPC分类号： H04W4/38 ,  H04W84/12

    摘要： Systems and methods of (remotely) controlling aspects of pools and spas and of modifying water contained therein are detailed. Internet-enabled access to pool and spa controllers may happen without any need for users to create firewall ports or utilize static internet protocol addresses. Certain networking devices may be configured using a USB connection or SD card, avoiding any requirement for an Ethernet cable or supplying separate power to the devices during configuration. Other devices may be configured wirelessly, without need of any USB connection or SD card. Time-varying data may be obtained in respect of one or more installations and analyzed for various information.

    摘要翻译： 详细说明（远程）控制水池和水疗中心及其中所含的水的改变的系统和方法。 可以在无需用户创建防火墙端口或使用静态互联网协议地址的情况下，可能会启用有Internet访问池和SPA控制器。 某些网络设备可能使用USB连接或SD卡进行配置，避免了以太网电缆的任何要求或在配置期间为设备提供单独的电源。 其他设备可以无线配置，无需任何USB连接或SD卡。 可以针对一个或多个安装获得时变数据，并分析各种信息。