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公开(公告)号：US5654139A
公开(公告)日：1997-08-05
申请号：US310271
申请日：1994-09-21
IPC分类号： G01N33/53 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/577 , C12N15/00
CPC分类号： C07K14/70571
摘要： We describe identification of a non-conservative amino acid substitution in the 5-HT.sub.2C receptor gene. The variant was found using single strand conformational polymorphism (SSCP) analysis. By typing this polymorphism in CEPH families, the gene was genetically mapped on the long arm of the X chromosome. Since this polymorphism was not detectable as a conventional RFLP, we also developed a PCR-RFLP based method which allows rapid genotyping in populations and families.
摘要翻译： 我们描述了5-HT2C受体基因中非保守氨基酸取代的鉴定。 使用单链构象多态性（SSCP）分析发现该变体。 通过在CEPH家族中打印该多态性，该基因被遗传地映射到X染色体的长臂上。 由于该多态性作为常规RFLP不能检测到，因此我们还开发了基于PCR-RFLP的方法，其允许在群体和家族中快速进行基因分型。
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公开(公告)号：US5763183A
公开(公告)日：1998-06-09
申请号：US745269
申请日：1996-11-08
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C07K14/70571 , C12Q2600/156
摘要： An allelic variant of the 5HT7 serotonin receptor was discovered. Family study data indicate that this variant can be correlated to alchoholic offerders. DNA encoding the variant protein, the protein itself, vectors containing the variant gene and cell lines carrying a vector with the variant gene are part of the invention.
摘要翻译： 发现了5HT7血清素受体的等位变体。 家庭研究数据表明，这种变体可以与alchoholic提供者相关联。 编码变体蛋白的DNA，蛋白质本身，含有变体基因的载体和携带变体基因的载体的细胞系是本发明的一部分。
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公开(公告)号：US5589331A
公开(公告)日：1996-12-31
申请号：US125628
申请日：1993-09-22
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method of detecting abnormal serotonergic function in an impulsive human subject is disclosed. The method comprises detecting an L allele of a gene encoding tryptophan hydroxylase. The invention also includes an isolated nucleic acid having a sequence specific to an L allele of a gene encoding tryptophan hydroxylase. The nucleic acid may migrate in a denaturing gel at the same rate as a second nucleic acid specific to a corresponding region of a U allele of a gene encoding tryptophan hydroxylase, and migrate in a nondenaturing gel at a rate about 1.02 times the migration rate of the second nucleic acid.
摘要翻译： 公开了一种检测冲动人类异常血清素能力的方法。 该方法包括检测编码色氨酸羟化酶的基因的L等位基因。 本发明还包括具有对编码色氨酸羟化酶的基因的L等位基因特异的序列的分离的核酸。 核酸可以以与编码色氨酸羟化酶的基因的U等位基因的相应区域特异性的第二核酸相同的速率迁移，并且以非变性凝胶的迁移率约为迁移率的1.02倍 第二核酸。
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4.发明授权Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates 有权含有固体布洛芬浓缩物的组合物和制备固体布洛芬浓缩物的方法公开(公告)号：US07582679B2
公开(公告)日：2009-09-01
申请号：US11346975
申请日：2006-02-03
IPC分类号： A61K31/19
CPC分类号： A61K9/1611 , A61K9/1635 , A61K31/192
摘要： The present invention is directed to a solid ibuprofen concentrate composition and method of producing the composition. The solid ibuprofen concentrate contains (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and is characterized in that at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt.
摘要翻译： 本发明涉及一种固体布洛芬浓缩物组合物及其制备方法。 固体布洛芬浓缩物含有（a）固体布洛芬游离酸和（b）固体布洛芬碱性盐，其特征在于固体布洛芬浓缩物的至少90％重量是布洛芬游离酸和布洛芬碱性盐。
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公开(公告)号：US20090213879A1
公开(公告)日：2009-08-27
申请号：US12363646
申请日：2009-01-30
IPC分类号： H01S3/10
CPC分类号： H01S3/10007 , H01S3/0057 , H01S3/0085 , H01S3/1301 , H01S3/2316
摘要： In exemplary embodiments, an ultra short pulse system comprises a laser platform which includes an optical source configured to generate an optical pulse, an optical amplifier configured to amplify the optical pulse, and a compressor configured to temporally compress the amplified optical pulse. The ultra short pulse system further comprises monitor circuitry configured to monitor one or more performance aspects of the laser platform. Additionally, the ultra short pulse system may comprise logic configured to control the one or more performance aspects of the laser platform in response to at least the monitored one or more performance aspects.
摘要翻译： 在示例性实施例中，超短脉冲系统包括激光平台，该激光平台包括被配置为产生光脉冲的光源，配置成放大光脉冲的光放大器和被配置为暂时压缩放大的光脉冲的压缩器。 超短脉冲系统还包括被配置为监测激光平台的一个或多个性能方面的监视器电路。 另外，超短脉冲系统可以包括被配置为响应于至少所监视的一个或多个性能方面来控制激光平台的一个或多个性能方面的逻辑。
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6.发明申请Effect of BDNF genotype on hippocampal function and verbal memory and risk for schizophrenia 审中-公开BDNF基因型对海马功能和语言记忆和精神分裂症风险的影响公开(公告)号：US20050014170A1
公开(公告)日：2005-01-20
申请号：US10789169
申请日：2004-02-27
申请人： Daniel Weinberger , Michael Egan , Bhaskar Kolachana , David Goldman , Joseph Callicott , Terry Goldberg
发明人： Daniel Weinberger , Michael Egan , Bhaskar Kolachana , David Goldman , Joseph Callicott , Terry Goldberg
IPC分类号： A61K38/00 , C07K14/475 , C12Q1/68 , C12Q1/6883
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/475 , C12Q2600/156
摘要： The invention is related to the discovery that a met66val polymorphism in the gene for brain-derived neurotrophic factor (BDNF) is correlated with hippocampal function and verbal memory and risk for neuropsychiatric disorders such as schizophrenia.
摘要翻译： 本发明涉及到脑源性神经营养因子（BDNF）基因中的met66val多态性与神经精神障碍如精神分裂症的海马功能和言语记忆以及风险相关的发现。
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公开(公告)号：US08139910B2
公开(公告)日：2012-03-20
申请号：US12259176
申请日：2008-10-27
申请人： Andrew D. Stadler , David Goldman , Mark Farley , Michael M. Mielke , Kyungbum Kim , Laurent Vaissié , Robert G. Waarts , Michael J. Cumbo
发明人： Andrew D. Stadler , David Goldman , Mark Farley , Michael M. Mielke , Kyungbum Kim , Laurent Vaissié , Robert G. Waarts , Michael J. Cumbo
CPC分类号： H01S3/0057 , G02B6/2706 , G02B6/2931 , G02B6/2932 , H01S3/083 , H01S3/235
摘要： A method of controlling an ultra-short pulse system is described comprising controlling an optical power within the ultra-short pulse system and control-system controlling a width of an optical pulse. In some embodiments, the method also comprises tuning a compressor by controlling a number of passes of the optical pulse through a Bragg grating to control the width of the optical pulse output from the compressor. In other embodiments, the method may comprise tuning a multi-pass stretcher by controlling a number of passes of the optical pulse through a loop of the multi-pass stretcher to control the width of the optical pulse output from the multi-pass stretcher. A method of controlling an ultra-short pulse system may also comprise accessing a control system from a remotely located command station, communicating status information from the control system to the command station, and communicating information from the command station to the control system.
摘要翻译： 描述了一种控制超短脉冲系统的方法，包括控制超短脉冲系统内的光功率和控制光脉冲宽度的控制系统。 在一些实施例中，该方法还包括通过控制通过布拉格光栅的光脉冲的通过次数来调节压缩器，以控制从压缩机输出的光脉冲的宽度。 在其他实施例中，该方法可以包括通过控制多通道担架的环路来控制光脉冲的通过次数来调整多通道担架，以控制从多通道担架输出的光脉冲的宽度。 控制超短脉冲系统的方法还可以包括从远程定位的命令站访问控制系统，将状态信息从控制系统传送到命令站，以及将信息从命令站传送到控制系统。
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公开(公告)号：US20090216494A1
公开(公告)日：2009-08-27
申请号：US12363636
申请日：2009-01-30
CPC分类号： H04B10/0773 , H04L41/147 , H04L43/06 , H04L43/50 , H04Q2213/1301
摘要： In exemplary embodiments, a network laser system comprises a laser platform including an optical source configured to generate an optical pulse, an optical amplifier configured to amplify the optical pulse, and a compressor configured to temporally compress the amplified optical pulse. The network laser system may also comprise monitor circuitry (e.g., sensors) configured to monitor one or more performance aspects of the laser platform. The network laser system may further comprise logic configured to transmit data to a remote computing device over a network. The network laser system may be configured to perform a diagnostic test and/or maintenance in response to instructions received from the remote computing device.
摘要翻译： 在示例性实施例中，网络激光系统包括激光平台，该激光平台包括被配置为产生光脉冲的光源，被配置为放大光脉冲的光放大器和被配置为暂时压缩放大的光脉冲的压缩器。 网络激光系统还可以包括被配置为监视激光平台的一个或多个性能方面的监视器电路（例如，传感器）。 网络激光系统还可以包括配置成通过网络将数据发送到远程计算设备的逻辑。 网络激光系统可以被配置为响应于从远程计算设备接收的指令来执行诊断测试和/或维护。
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公开(公告)号：US07273699B2
公开(公告)日：2007-09-25
申请号：US10206561
申请日：2002-07-25
申请人： Robert H. Lipsky , Chiara Mazzanti , David Goldman
发明人： Robert H. Lipsky , Chiara Mazzanti , David Goldman
CPC分类号： C12Q1/6827 , C12Q2527/107 , C12Q2527/113
摘要： Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.
摘要翻译： 通过检测多个核酸的融合谱之间或之间的差异来检测序列变异，例如多态性。 通过在一段时间内在温度变化期间观察核酸来产生熔融曲线。 如果将核酸稀释成用于分析的溶液，则溶液之间或之间的核酸浓度可以基本上相同。 融合谱和序列变异可用于鉴定野生型核酸序列的变化，如单核苷酸多态性（SNP），小插入或缺失或小反转。
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10.发明授权
公开(公告)号：US5843930A
公开(公告)日：1998-12-01
申请号：US838473
申请日：1997-04-07
申请人： Shivaji Purwar , David Goldman
发明人： Shivaji Purwar , David Goldman
CPC分类号： A61K9/0046 , A61K31/57 , A61K47/32 , A61K9/10
摘要： The invention is directed to a method of treating otitis which comprises introducing an antibacterially-effective amount of a composition comprising a non-ototoxic, topical, otic pharmaceutic composition comprising (a) ciprofloxacin in aqueous solution in an amount effective for antibacterial action; (b) a non-ionic viscosity augmenter unaffected by pH and ionic level, said viscosity augmenter being present in an amount effective for augmenting viscosity of the composition to a viscosity greater than that of water, said viscosity augmenter being at least 85% hydrolyzed polyvinyl alcohol; (c) a non-ototoxic preservative present in an amount effective for antibacterial action, the preservative being benzyl alcohol; (d) water sufficient to produce an aqueous composition; (e) hydrocortisone in aqueous suspension in an amount effective for anti-inflammatory action; (f) lecithin in an amount effective for enhancing suspension of other constituents in the composition; and (g) polysorbate ranging from polysorbate 20 to 80 in an amount effective for spreading the preparation on a hydrophobic skin surface to the site of infection or inflammation.
摘要翻译： 本发明涉及一种治疗耳炎的方法，其包括引入抗菌有效量的包含非耳毒性，局部，耳用药物组合物的组合物，其包含（a）环丙沙星在水溶液中，其量为有效抗菌作用的量; （b）不受pH和离子水平影响的非离子粘度增强剂，所述粘度增加剂以有效增加组合物粘度至粘度大于水的粘度的量存在，所述粘度增加剂为至少85％的水解聚乙烯 醇; （c）以有效抗菌作用的量存在的非耳毒性防腐剂，该防腐剂为苄醇; （d）足以产生含水组合物的水; （e）水性悬浮液中的氢化可的松，其量为有效抗炎作用的量; （f）卵磷脂，其用量有效地增强组合物中其他成分的悬浮液; 和（g）范围从聚山梨酸酯20至80的聚山梨醇酯，其量有效地将制剂铺展在疏水性皮肤表面至感染或炎症部位。
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