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公开(公告)号:US07799933B2
公开(公告)日:2010-09-21
申请号:US11951426
申请日:2007-12-06
IPC分类号: A61K31/404 , C07D209/12
CPC分类号: C07D209/08 , C07D215/58 , C07D417/12
摘要: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R1, R2, R3, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型磺酰胺衍生物,其中R 1,R 2,R 3,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用作药物。
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12.
公开(公告)号:US20110046112A1
公开(公告)日:2011-02-24
申请号:US12941374
申请日:2010-11-08
申请人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
发明人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
IPC分类号: A61K31/553 , C07D265/36 , C07D413/12 , C07D241/50 , C07D263/56 , C07D267/14 , C07D267/22 , C07D279/16 , C07D265/16 , A61K31/538 , A61K31/498 , A61K31/423 , A61K31/4439 , A61K31/395 , A61K31/5415 , A61P3/10
CPC分类号: C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型杂双环衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,V,W,X和Y如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US20110015234A1
公开(公告)日:2011-01-20
申请号:US12877160
申请日:2010-09-08
IPC分类号: A61K31/4439 , C07D231/56 , C07D409/12 , C07D401/12 , C07D405/12 , C07D403/12 , C07D413/12 , A61K31/416 , A61K31/427 , A61K31/4245 , A61P1/16
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used in the prevention or treatment of diseases which are modulated by L-CPT1 inhibitors.
摘要翻译: 本发明涉及式(I)的新的吲唑衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于预防或治疗由L-CPT1抑制剂调节的疾病。
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14.
公开(公告)号:US20100130484A1
公开(公告)日:2010-05-27
申请号:US12696145
申请日:2010-01-29
申请人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
发明人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
IPC分类号: C07D265/36 , A61K31/538 , C07D241/36 , A61K31/498 , C07D263/54 , A61K31/423 , A61K31/5415 , C07D279/16 , A61P3/10
CPC分类号: C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型杂双环衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,V,W,X和Y如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US07858645B2
公开(公告)日:2010-12-28
申请号:US11875025
申请日:2007-10-19
IPC分类号: A61K31/416 , A61K31/4155 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used in the prevention or treatment of diseases which are modulated by L-CPT1 inhibitors.
摘要翻译: 本发明涉及式(I)的新的吲唑衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,X和Y如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用于预防或治疗由L-CPT1抑制剂调节的疾病。
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16.
公开(公告)号:US20070191603A1
公开(公告)日:2007-08-16
申请号:US11703319
申请日:2007-02-07
申请人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
发明人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
IPC分类号: A61K31/5415 , C07D265/12 , C07D265/36
CPC分类号: C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型杂双环衍生物,其中R 1,R 2,R 3,R 4, R 5,R 5,R 6,V,W,X和Y如说明书和权利要求书中所定义,以及生理上可接受的盐和酯 其中。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US07879845B2
公开(公告)日:2011-02-01
申请号:US12696145
申请日:2010-01-29
申请人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
发明人: Jean Ackermann , Konrad Bleicher , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei , Ulrike Obst Sander
IPC分类号: C07D279/16 , A61K31/5415
CPC分类号: C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型杂双环衍生物,其中R 1,R 2,R 3,R 4,R 5,R 6,V,W,X和Y如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US20080153805A1
公开(公告)日:2008-06-26
申请号:US11951426
申请日:2007-12-06
IPC分类号: A61K31/404 , A61K31/427 , A61K31/55 , A61P3/10 , C07D209/04 , C07D223/16 , C07D417/02
CPC分类号: C07D209/08 , C07D215/58 , C07D417/12
摘要: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R1, R2, R3, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型磺酰胺衍生物,其中R 1,R 2,R 3,R 3,X和Y定义如上 在说明书和权利要求书中,以及其生理上可接受的盐和酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US20100267722A1
公开(公告)日:2010-10-21
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: A61K31/5377 , C07D207/16 , A61K31/401 , A61P9/10 , A61P11/00 , A61P13/12 , C07D403/12 , A61K31/4178 , A61K31/496 , A61K31/501 , C07D413/12 , C07D487/04 , A61K31/407 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US08163793B2
公开(公告)日:2012-04-24
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/10 , C07D409/04 , C07D405/14 , C07D405/10 , C07D405/04 , C07D401/14 , C07D401/10 , C07D401/04 , C07D403/14 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D207/16 , A61K31/541 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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