公开(公告)号：US20220378904A1

公开(公告)日：2022-12-01

申请号：US17737581

申请日：2022-05-05

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Christine Shaw ,  Igor Smolenov ,  Michael Watson ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/51

Abstract: Provided herein are vaccine composition comprising a chemically-modified messenger ribonucleic acid (mRNA) encoding a hMPV fusion (F) glycoprotein and a chemically-modified mRNA encoding a hPIV3 F glycoprotein formulated in a cationic lipid nanoparticle formulation, and related method for inducing an antigen-specific immune response.

公开(公告)号：US11364292B2

公开(公告)日：2022-06-21

申请号：US16898268

申请日：2020-06-10

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K48/00 ,  A61K9/14 ,  A61K9/00 ,  C07K16/28 ,  C07K14/005 ,  C07K16/10 ,  C07K14/18 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51 ,  A61K39/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20200368344A1

公开(公告)日：2020-11-26

申请号：US16898268

申请日：2020-06-10

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/00 ,  C07K16/28 ,  C07K14/005 ,  C07K16/10 ,  A61K9/14 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20200289638A1

公开(公告)日：2020-09-17

申请号：US16850519

申请日：2020-04-16

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20190008946A1

公开(公告)日：2019-01-10

申请号：US16136386

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20180008694A1

公开(公告)日：2018-01-11

申请号：US15674591

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/513 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2770/24034 ,  C12N2770/24134 ,  C12N2770/36134 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/392

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20230020362A1

公开(公告)日：2023-01-19

申请号：US17737532

申请日：2022-05-05

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/14 ,  A61K9/51 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  A61P31/12 ,  A61P31/14 ,  C07K14/005 ,  C07K14/18 ,  C07K16/10 ,  C07K16/28 ,  C12N7/00 ,  A61K9/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20220257746A1

公开(公告)日：2022-08-18

申请号：US17590479

申请日：2022-02-01

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20220152178A1

公开(公告)日：2022-05-19

申请号：US17554182

申请日：2021-12-17

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: A61K39/00 ,  A61K45/06 ,  A61K47/54 ,  A61K47/68 ,  A61P35/00 ,  A61K9/127 ,  A61K47/26 ,  C12N15/62

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US10449244B2

公开(公告)日：2019-10-22

申请号：US16009811

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu

IPC: A61K39/12 ,  A61P31/12 ,  A61P31/14 ,  A61K9/14 ,  A61K9/51 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C07K16/28 ,  A61K39/00

Abstract: Aspects of the disclosure describe compositions that comprise RNA polynucleotides having an open reading frame encoding one or more Zika virus antigens. Methods for preparing and using the compositions are also described.