公开(公告)号：US07446123B2

公开(公告)日：2008-11-04

申请号：US10552455

申请日：2004-01-07

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC分类号： A61K31/40 ,  A61K31/4035 ,  C07D209/52

CPC分类号： C07D209/52 ,  C07D403/06

摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080255188A1

公开(公告)日：2008-10-16

申请号：US11995433

申请日：2006-07-11

申请人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

发明人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

IPC分类号： A61K31/472 ,  C07D217/26

CPC分类号： C07D471/08

摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20100144801A1

公开(公告)日：2010-06-10

申请号：US12443838

申请日：2007-10-02

申请人： Naresh Kumar ,  Jaskiran Kaur ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

发明人： Naresh Kumar ,  Jaskiran Kaur ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

IPC分类号： A61K31/44 ,  C07D213/55 ,  C07D233/54 ,  A61K31/4164 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00 ,  A61P3/00

CPC分类号： C07D233/64 ,  C07D211/70 ,  C07D213/30

摘要： The present invention generally relates to muscarinic receptor antagonists of formula I, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Formula (I) wherein Het: is heterocyclyl or heteroaryl X: O, S or NR1 and the other substituents are defined as in the claims.

摘要翻译： 本发明一般涉及式I的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 式（I）其中Het：是杂环基或杂芳基X：O，S或NR1，其它取代基如权利要求中所定义。

公开(公告)号：US07544708B2

公开(公告)日：2009-06-09

申请号：US10520572

申请日：2003-04-11

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

IPC分类号： A61K31/40 ,  C07D209/44

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 具体地，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷和2,4,6-三取代的衍生物。 本发明还涉及含有化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20070021487A1

公开(公告)日：2007-01-25

申请号：US10552503

申请日：2004-01-06

申请人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

发明人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

IPC分类号： A61K31/403 ,  C07D209/02

CPC分类号： C07D209/52 ,  C07D403/06

摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20060111425A1

公开(公告)日：2006-05-25

申请号：US10520572

申请日：2003-04-11

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

IPC分类号： A61K31/403 ,  C07D403/02 ,  C07D209/02

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

公开(公告)号：US06900296B2

公开(公告)日：2005-05-31

申请号：US10276505

申请日：2001-05-07

申请人： Mohammad Salman ,  Parma Chandra Ray ,  Kiran Kumar Gangakhedkar ,  Harish Niranjan Lal Dorwal ,  Naresh Kumar

发明人： Mohammad Salman ,  Parma Chandra Ray ,  Kiran Kumar Gangakhedkar ,  Harish Niranjan Lal Dorwal ,  Naresh Kumar

IPC分类号： C07H17/08 ,  C07H1/00

CPC分类号： C07H17/08

摘要： The invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivative which comprised methylating the erythromycin A derivative with a methylating agent in a mixture of toluene and a ploar aprotic solvent.

摘要翻译： 本发明涉及在红霉素A衍生物的6位选择性甲基化羟基的成本有效和工业上有利的方法，该方法包括用甲基化剂甲苯化红霉素A衍生物与甲苯和异质非质子溶剂的混合物。

公开(公告)号：US07148355B2

公开(公告)日：2006-12-12

申请号：US10490275

申请日：2002-09-24

申请人： Purna Chandra Ray ,  Jayachandra Suresh Babu ,  Mohammad Salman ,  Naresh Kumar

发明人： Purna Chandra Ray ,  Jayachandra Suresh Babu ,  Mohammad Salman ,  Naresh Kumar

IPC分类号： C07D211/32

CPC分类号： C07D295/135

摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of repaglinide.

摘要翻译： 本发明涉及用于制备瑞格列奈的成本效益和工业上有利的方法。

公开(公告)号：US20100035954A1

公开(公告)日：2010-02-11

申请号：US11721838

申请日：2004-12-15

申请人： Mohammad Salman ,  Naresh Kumar

发明人： Mohammad Salman ,  Naresh Kumar

IPC分类号： A61K31/403 ,  C07D209/52 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00

CPC分类号： C07D209/52

摘要： Provided herein are acid addition salts of muscarinic receptor antagonists. Such acid addition salts are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided herein are processes for the preparation of acid addition salts, pharmaceutical compositions thereof, and methods of treating diseases mediated through muscarinic receptors.

摘要翻译： 本文提供毒蕈碱受体拮抗剂的酸加成盐。 这种酸加成盐是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 本文还提供了制备酸加成盐，其药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20050027143A1

公开(公告)日：2005-02-03

申请号：US10487554

申请日：2002-08-23

申请人： Mohammad Salman ,  Purna Ray ,  Suresh Babu ,  Naresh Kumar

发明人： Mohammad Salman ,  Purna Ray ,  Suresh Babu ,  Naresh Kumar

IPC分类号： C07C29/147 ,  C07C33/14 ,  C07C45/29 ,  C07C47/225 ,  C07C67/343 ,  C07C403/14 ,  C07C45/45

CPC分类号： C07C403/14 ,  C07B2200/09 ,  C07C29/147 ,  C07C33/14 ,  C07C67/343 ,  C07C403/08 ,  C07C403/20 ,  C07C2601/16 ,  C07C69/608

摘要： The present invention relates to an industrially advantageous process for the preparation of beta-ionylidencacetaldehyde of structural Formula I, which is a key intermediate for the synthesis of vitamin A and related compounds such as tretinoin and isotretinoin.

摘要翻译： 本发明涉及一种工业上有利的制备结构式I的β-离子亚基乙醛的方法，其是合成维生素A和相关化合物如维A酸和异维A酸的关键中间体。