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11.发明申请公开(公告)号：US20170216430A1
公开(公告)日：2017-08-03
申请号：US15501281
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Kyohei MATSUSHITA , Mitsuhiko HORI
IPC: A61K39/39
CPC classification number: A61K39/39 , A61K45/00 , A61K2039/54 , A61K2039/572 , A61K2039/575
Abstract: The present invention aims to provide a composition for promoting immunity induction and a vaccine pharmaceutical composition which are universally usable for inducing immunity to various antigens and capable of exerting a high immunity inducing effect. The present invention relates to a composition for promoting immunity induction containing at least one nuclear receptor ligand and also relates to a vaccine pharmaceutical composition for inducing immunity containing an antigen and a composition for promoting immunity induction that is at least one nuclear receptor ligand.
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公开(公告)号：US20160058711A1
公开(公告)日：2016-03-03
申请号：US14813797
申请日：2015-07-30
Applicant: NITTO DENKO CORPORATION
Inventor： Kyohei MATSUSHITA , Daisuke ASARI , Takuya SHISHIDO , Mitsuhiko HORI
IPC: A61K9/70 , A61K47/32 , A61K47/18 , A61K31/422 , A61K47/38 , A61K31/138 , A61K31/18 , A61K31/439 , A61K31/137 , A61K31/46 , A61K9/00 , A61K31/426
CPC classification number: A61K9/7007 , A23L33/13 , A23L33/17 , A23L33/175 , A23P10/00 , A61K9/00 , A61K9/0056 , A61K9/006 , A61K9/2054 , A61K9/70 , A61K9/7015 , A61K31/137 , A61K31/138 , A61K31/18 , A61K31/422 , A61K31/426 , A61K31/439 , A61K31/46 , A61K31/48 , A61K31/7052 , A61K31/715 , A61K31/79 , A61K38/00 , A61K47/10 , A61K47/183 , A61K47/32 , A61K47/36 , A61K47/38
Abstract: The present invention aims to provide an oral film-form base and an oral film-form preparation which have a rapid dissolution profile in the mouth and sufficient film strength, give a good tactile impression when handled with fingers and favorable texture and taste in the mouth, and are administrable to those who have limitation in carbohydrate intake. The present invention relates to an oral film-form base including an edible polymer soluble in water and an organic solvent having a solubility parameter of 9.7 or higher, and particles of at least one compound selected from the group consisting of amino acid, dipeptide, and nucleotide, the particles of at least one compound selected from the group consisting of amino acid, dipeptide, and nucleotide being dispersed in the state of particles in the oral film-form base.
Abstract translation: 本发明的目的是提供一种在口中具有快速溶出曲线并具有足够的膜强度的口腔膜形式基质和口腔膜形式制剂，在手指处理时具有良好的触觉，口中具有良好的质地和味道 并且对那些在碳水化合物摄入方面有限制的人群是可以管理的。 本发明涉及包含可溶于水的食用聚合物和溶解度参数为9.7以上的有机溶剂的口腔膜型基质，以及至少一种选自氨基酸，二肽和 核苷酸，选自氨基酸，二肽和核苷酸的至少一种化合物的颗粒以口腔膜形式的基质中的颗粒状态分散。
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公开(公告)号：US20140220079A1
公开(公告)日：2014-08-07
申请号：US14166973
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Daisuke ASARI , Arimichi OKAZAKI , Kyohei MATSUSHITA , Katsuyuki OKUBO , Yoshiki MAEDA , Takuya SHISHIDO , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/39 , A61K39/0011 , A61K2039/541 , A61K2039/542
Abstract: The present invention provides a cancer vaccine composition for mucosal administration comprising (i) a HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于粘膜给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。
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公开(公告)号：US20130177594A1
公开(公告)日：2013-07-11
申请号：US13733253
申请日：2013-01-03
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Mitsuhiko HORI
CPC classification number: A61K47/36 , A61K9/0056 , A61K9/19 , A61K38/168 , A61K39/36 , A61K47/26 , A61K47/32
Abstract: The present invention provides a pharmaceutical composition capable of preserving and delivering an allergen having poor thermal stability without using gelatin as a stabilizer, and a method for producing the pharmaceutical composition. The present invention provides a pharmaceutical composition containing an allergen and additives selected from at least two groups from among group (A) consisting of polysaccharides having high formability; group (B) consisting of mono- to hexasaccharides, sugar alcohols thereof, maltodextrin, and polyvinylpyrrolidone; and group (C) consisting of viscous polysaccharides; wherein the additives have a stabilizing effect on the allergen.
Abstract translation: 本发明提供能够保存并输送热稳定性差的变应原剂而不使用明胶作为稳定剂的药物组合物，以及该药物组合物的制造方法。 本发明提供含有变应原和添加剂的药物组合物，所述组合物选自由具有高成形性的多糖组成的组（A）中的至少两组; 由一至六糖组成的组（B），其糖醇，麦芽糖糊精和聚乙烯吡咯烷酮; 和由粘性多糖组成的组（C）; 其中所述添加剂对变应原具有稳定作用。
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公开(公告)号：US20180326041A1
公开(公告)日：2018-11-15
申请号：US15777396
申请日：2016-11-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Eiji KIYOTOH , Kyohei MATSUSHITA , Wenjing LI , Masahiro FUKASAKA , Katsuyuki OKUBO , Mitsuhiko HORI
CPC classification number: A61K39/145 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K2039/5252 , A61K2039/542 , A61K2039/55511 , A61K2039/70 , A61P31/16
Abstract: The present invention provides a vaccine pharmaceutical composition for oral administration that enables stable storage of an influenza virus antigen and a method for producing the pharmaceutical composition. Provided is a vaccine pharmaceutical composition for oral administration containing an influenza virus antigen, an excipient, a disaccharide, and an amino acid.
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Patent Agency Ranking
公开(公告)号：US20170028054A1
公开(公告)日：2017-02-02
申请号：US15290031
申请日：2016-10-11
Applicant: NITTO DENKO CORPORATION
Inventor： Masahiro FUKASAKA , Arimichi OKAZAKI , Daisuke ASARI , Mitsuhiko HORI , Shizuo AKIRA , Osamu TAKEUCHI
IPC: A61K39/145 , C12N7/00 , A61K39/39
CPC classification number: A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/00034 , C12N2760/16034 , C12N2760/16134 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/489
Abstract: An intraorally administrable vaccine composition useful to be a preventive or therapeutic agent for infectious diseases, and effectively induces a systemic immune response or a mucosal immune response is provided. A vaccine composition for administration to the oral cavity of a human or an animal, the vaccine composition containing at least one antigen derived from an infectious disease, and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic dinucleotide, or a derivative or salt thereof.
Abstract translation: 提供可用于感染性疾病的预防或治疗剂，有效诱导全身免疫应答或粘膜免疫应答的口服给药的疫苗组合物。 一种用于给予人或动物口腔的疫苗组合物，所述疫苗组合物含有至少一种源自感染性疾病的抗原，以及至少一种选自toll样受体4（TLR4）激动剂 ，一种toll样受体2/6（TLR2 / 6）激动剂和环二核苷酸，或其衍生物或盐。
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公开(公告)号：US20160206728A1
公开(公告)日：2016-07-21
申请号：US14915342
申请日：2014-10-02
Applicant: NITTO DENKO CORPORATION
Inventor： Eiji KIYOTOH , Mitsuhiko HORI , Daisuke ASARI , Arimichi OKAZAKI , Masahiro FUKASAKA
IPC: A61K39/145 , C12N7/00
CPC classification number: A61K39/145 , A61K9/19 , A61K31/7016 , A61K39/12 , A61K47/26 , A61K2039/525 , A61K2039/55511 , C12N7/00 , C12N2760/16034 , C12N2760/16134 , A61K2300/00
Abstract: The present invention provides a dried influenza vaccine preparation in which the activity of an influenza vaccine antigen can be stably maintained even when stored without strictly maintaining a low temperature, and which can be stably supplied. The present invention also provides a method of producing the dried influenza vaccine preparation. The present invention provides a dried influenza vaccine preparation containing an influenza vaccine antigen and a disaccharide, wherein the disaccharide is at least one selected from the group consisting of sucrose, maltose, palatinose, melibiose, isomalt, cellobiose, allolactose, isomaltose, sophorose, lactobionic acid, laminaribiose, xylobiose, turanose, gentiobiose, rutinose, kojibiose, nigerose, robinose, neohesperidose, sucralose, and maltitol.
Abstract translation: 本发明提供一种干流感疫苗制剂，其中流感疫苗抗原的活性即使在不严格保持低温储存的情况下也可以稳定地保持，并且可以稳定地供应。 本发明还提供了制备干流感疫苗制剂的方法。 本发明提供含有流感疫苗抗原和二糖的干燥流感疫苗制剂，其中二糖是选自蔗糖，麦芽糖，帕拉金糖，蜜二糖，异麦芽糖醇，纤维二糖，异乳糖，异麦芽糖，槐糖，乳糖酸 酸，层状二糖，木二糖，吐木糖，龙胆糖，芦丁糖，曲霉糖，尼黑糖，罗西糖，新月皮糖，三氯蔗糖和麦芽糖醇。
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公开(公告)号：US20200376111A1
公开(公告)日：2020-12-03
申请号：US16996433
申请日：2020-08-18
Applicant: NITTO DENKO CORPORATION
Inventor： Masahiro FUKASAKA , Arimichi OKAZAKI , Daisuke ASARI , Mitsuhiko HORI , Shizuo AKIRA , Osamu TAKEUCHI
IPC: A61K39/145 , A61K39/12 , A61K39/39 , C12N7/00
Abstract: A vaccine composition for administration to the oral cavity of a human or an animal, the vaccine composition containing at least one antigen derived from an infectious disease, and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic dinucleotide, or a derivative or salt thereof.
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公开(公告)号：US20170246287A1
公开(公告)日：2017-08-31
申请号：US15337644
申请日：2016-10-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
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20.发明申请公开(公告)号：US20170224813A1
公开(公告)日：2017-08-10
申请号：US15501350
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Arimichi OKAZAKI , Daisuke ASARI , Mitsuhiko HORI
CPC classification number: A61K39/39 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K45/00 , A61K2039/54 , A61K2039/55511 , A61K2039/55516
Abstract: The present invention aims to provide a vaccine pharmaceutical composition that can be universally used for induction of cellular immunity to various antigens and that exerts a high inducing effect. The present invention relates to a vaccine pharmaceutical composition that suppresses apoptosis of CTL or inhibits suppression of induction of CTL.
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