-
公开(公告)号：US09573998B2
公开(公告)日：2017-02-21
申请号：US14605560
申请日：2015-01-26
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。
-
12.发明授权Method of treating cancer by administering a monoclonal antibody that binds human NOTCH2 and NOTCH3 有权通过施用结合人NOTCH2和NOTCH3的单克隆抗体来治疗癌症的方法公开(公告)号：US09505832B2
公开(公告)日：2016-11-29
申请号：US14600641
申请日：2015-01-20
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： C07K16/00 , C07K16/28 , C07K16/30 , A61K39/00 , A61K39/395 , C07K16/22 , A61K45/06 , C07K16/46 , C12N5/09 , C07K14/705 , C07K14/71 , C07K14/435 , C12N15/63 , C12N15/79 , C07H21/04 , C12N5/12
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
-
公开(公告)号：US09499613B2
公开(公告)日：2016-11-22
申请号：US14577484
申请日：2014-12-19
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , C07K16/22 , A61K45/06 , C07K16/46 , C07K16/30 , C12N5/09 , C07K14/705 , C07K14/71 , C07K14/435 , C12N15/63 , C12N15/79 , C07H21/04 , C12N5/12 , A61K39/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了特异性结合人Notch受体细胞外结构域的非配体结合膜近端区域并抑制肿瘤生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合膜近端区域并抑制肿瘤生长的抗体。
-
公开(公告)号：US09416178B2
公开(公告)日：2016-08-16
申请号：US14572321
申请日：2014-12-16
IPC分类号： C07H21/02 , C07H21/04 , C12N5/10 , C12N5/12 , C12N15/13 , C07K16/28 , C07K16/18 , A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2896 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to Jagged-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind to an extracellular domain of human Jagged1 or human Jagged2 and modulate Jagged activity. The present invention further provides methods of using agents that modulate the activity of Jagged, such as antibodies that specifically bind Jagged, and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
摘要翻译： 本发明涉及锯齿结合剂和使用该药物治疗诸如癌症的疾病的方法。 本发明提供特异性结合人Jagged1或人Jagged2细胞外结构域并调节Jagged活性的抗体。 本发明还提供使用调节Jagged的活性的试剂的方法，例如特异性结合Jagged的抗体，并抑制肿瘤生长。 还描述了治疗癌症的方法，其包括向具有肿瘤或癌症的患者施用治疗有效量的本发明的药剂或抗体。
-
公开(公告)号：US09181333B2
公开(公告)日：2015-11-10
申请号：US13940834
申请日：2013-07-12
IPC分类号： C07K16/18 , A61K39/395 , A61K45/06 , C12Q1/68 , C07K16/30
CPC分类号： C07K16/30 , A61K39/39533 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/60 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
摘要翻译： 本发明涉及RSPO结合剂，特别是RSPO3结合剂和使用该药物治疗诸如癌症的疾病的方法。 本发明提供了特异性结合人RSPO3蛋白并调节和 - 连接蛋白活性的抗体。 本发明还提供使用调节RSPO3蛋白活性并抑制肿瘤生长的试剂的方法。 还描述了治疗癌症的方法，其包括向具有肿瘤或癌症的患者施用治疗有效量的本发明的药剂或抗体。
-
公开(公告)号：US09023621B2
公开(公告)日：2015-05-05
申请号：US14020012
申请日：2013-09-06
IPC分类号： C12P21/04 , C12P21/06 , C12N15/00 , C12N15/10 , C07K14/73 , C07K16/00 , C07K16/22 , C07K16/28 , G01N33/68
CPC分类号： C07K14/70514 , C07K16/00 , C07K16/22 , C07K16/28 , C07K16/2851 , C07K16/2863 , C07K2317/34 , C07K2317/52 , C07K2317/64 , C07K2319/035 , C07K2319/30 , C07K2319/43 , C07K2319/60 , C12N15/1037 , G01N33/6845 , G01N33/6854
摘要： The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies.
-
公开(公告)号：US08945874B2
公开(公告)日：2015-02-03
申请号：US13801613
申请日：2013-03-13
IPC分类号： C07H21/04 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/13 , C07K16/28 , C12N7/01 , C07K16/30 , A61K39/395 , A61K45/06 , C07K16/46 , C07K16/22 , C07K14/705 , C07K14/71 , C07K14/435 , C12N15/63 , C12N15/79 , A61K39/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了与人Notch受体的细胞外结构域的非配体结合膜近端区域特异性结合并抑制肿瘤生长的抗体。 本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合膜近端区域并抑制肿瘤生长的抗体。
-
公开(公告)号：US20130295106A1
公开(公告)日：2013-11-07
申请号：US13800801
申请日：2013-03-13
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： G01N33/5011 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K14/4702 , C07K14/71 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N2333/726 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体和其他多肽。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。 还提供筛选方法。
-
公开(公告)号：US20210403553A1
公开(公告)日：2021-12-30
申请号：US17330716
申请日：2021-05-26
发明人： Christopher Lamond Murriel , Timothy Charles Hoey , Austin L. Gurney , Julie Michelle Roda , Minu K. Srivastava , Inkyung Park , Jakob Dupont
IPC分类号： C07K16/28 , A61K39/395 , C12N15/113 , A61K31/282 , A61K31/519
摘要： The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.
-
公开(公告)号：US09873726B2
公开(公告)日：2018-01-23
申请号：US15210250
申请日：2016-07-14
CPC分类号： C07K14/70514 , C07K16/00 , C07K16/22 , C07K16/28 , C07K16/2851 , C07K16/2863 , C07K2317/34 , C07K2317/52 , C07K2317/64 , C07K2319/035 , C07K2319/30 , C07K2319/43 , C07K2319/60 , C12N15/1037 , G01N33/6845 , G01N33/6854
摘要： The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies.
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.069 秒)
