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    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES
    11.
    发明申请
    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES 有权

    公开(公告)号：US20230115304A1

    公开(公告)日：2023-04-13

    申请号：US18075578

    申请日：2022-12-06

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    ION FOCUSING
    12.
    发明申请
    ION FOCUSING 有权

    公开(公告)号：US20220216046A1

    公开(公告)日：2022-07-07

    申请号：US17148737

    申请日：2021-01-14

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    SYSTEMS AND METHODS FOR SYNTHESIZING A REACTION PRODUCT AND INCREASING YIELD OF THE SAME
    16.
    发明申请
    SYSTEMS AND METHODS FOR SYNTHESIZING A REACTION PRODUCT AND INCREASING YIELD OF THE SAME 有权

    公开(公告)号：US20210299666A1

    公开(公告)日：2021-09-30

    申请号：US17183691

    申请日：2021-02-24

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zhenwei Wei

    IPC: B01L7/00 ,  B01L7/02

    Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.

    Systems and methods for increasing reaction yield
    18.
    发明授权
    Systems and methods for increasing reaction yield 有权

    公开(公告)号：US11045783B2

    公开(公告)日：2021-06-29

    申请号：US15673658

    申请日：2017-08-10

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  David Logsdon

    IPC: B01J19/24 ,  B01J14/00 ,  B01J19/08 ,  B01J19/26 ,  B01D5/00 ,  B01D19/00 ,  B05B5/03 ,  B01J4/00 ,  H01J49/26 ,  B05B5/025

    Abstract: The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.

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