公开(公告)号：US06867016B1

公开(公告)日：2005-03-15

申请号：US09052855

申请日：1998-03-31

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K16/3046 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为CS141并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS141编码的多肽或蛋白质的抗体以及预防组织特异性CS141多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。

公开(公告)号：US06770435B1

公开(公告)日：2004-08-03

申请号：US09431384

申请日：1999-11-01

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BU101并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：US06368792B1

公开(公告)日：2002-04-09

申请号：US09049698

申请日：1998-03-27

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US06538119B2

公开(公告)日：2003-03-25

申请号：US09193881

申请日：1998-11-18

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS249 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS249-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS249 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

摘要翻译： 描述了一组由此编码的连续和部分重叠的cDNA序列和多肽，命名为BS249并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS249编码的多肽或蛋白质的抗体，以及预防组织特异性BS249多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

公开(公告)号：US6110675A

公开(公告)日：2000-08-29

申请号：US946869

申请日：1997-10-08

申请人： Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

发明人： Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K14/82 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/574 ,  C12Q1/70 ,  C07H21/04 ,  C12P19/34 ,  G01N33/53

CPC分类号： C07K14/82 ,  C07K14/47 ,  C12Q1/6886 ,  G01N33/57434 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，称为PS112并从前列腺组织转录。 还公开了表示PS112的连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS112编码的多肽或蛋白质的抗体，以及预防组织特异性PS112多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06207380B1

公开(公告)日：2001-03-27

申请号：US09153804

申请日：1998-09-15

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Eric Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Eric Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Polypeptides and polynucleotides useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary cancer, are described. These sequences are derived from keratin/cytokeratin, CAS, or mat-8 polypeptides and polynucleotides. Also provided are antibodies which specifically bind to keratin/cytokeratin, CAS, or mat-8-encoded polypeptides or proteins, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

摘要翻译： 描述了可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对尿路疾病和状况（例如尿癌）的倾向的多肽和多核苷酸。 这些序列衍生自角蛋白/细胞角蛋白，CAS或mat-8多肽和多核苷酸。 还提供了特异性结合角蛋白/细胞角蛋白，CAS或mat-8编码的多肽或蛋白质的抗体，该分子可用于治疗尿路疾病，肿瘤或转移瘤。

公开(公告)号：US5939265A

公开(公告)日：1999-08-17

申请号：US964725

申请日：1997-11-05

申请人： Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Steven D. Stroupe

发明人： Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Steven D. Stroupe

IPC分类号： C12Q1/68 ,  C12N15/00 ,  C12N15/63 ,  C12N15/85

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.

摘要翻译： 描述了一组由此编码的连续和部分重叠的RNA序列和多肽，命名为LU103并从肺组织转录。 还公开了表示LU103的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗，或确定个体对肺部疾病和病症的倾向，如肺癌。

公开(公告)号：US07122653B2

公开(公告)日：2006-10-17

申请号：US10082659

申请日：2002-02-25

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H21/04 ,  C07H1/00 ,  C07H5/04 ,  C07H5/06 ,  C07H19/00

CPC分类号： G01N33/57434

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：US06350583B1

公开(公告)日：2002-02-26

申请号：US09566876

申请日：2000-05-08

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： G01N3353

CPC分类号： G01N33/57434

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS190并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS190编码的多肽或蛋白质的抗体，以及预防组织特异性PS190多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06232456B1

公开(公告)日：2001-05-15

申请号：US08944483

申请日：1997-10-06

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

IPC分类号： C12N1557

CPC分类号： C12N9/6424

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present invention is a member of the human serine protease family. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS133-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS133 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS133并从前列腺组织转录。 本发明的一种多肽是人丝氨酸蛋白酶家族的成员。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS133编码的多肽或蛋白质的抗体，以及预防组织特异性PS133多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。