公开(公告)号：US06232456B1

公开(公告)日：2001-05-15

申请号：US08944483

申请日：1997-10-06

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

IPC分类号： C12N1557

CPC分类号： C12N9/6424

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present invention is a member of the human serine protease family. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS133-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS133 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS133并从前列腺组织转录。 本发明的一种多肽是人丝氨酸蛋白酶家族的成员。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS133编码的多肽或蛋白质的抗体，以及预防组织特异性PS133多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US07479537B2

公开(公告)日：2009-01-20

申请号：US11126456

申请日：2005-05-11

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07K5/00

CPC分类号： G01N33/57415 ,  A61K38/00 ,  C07K14/47 ,  C07K16/3015 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为BS106并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及预防组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：US06949357B2

公开(公告)日：2005-09-27

申请号：US09092297

申请日：1998-06-05

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

IPC分类号： G01N33/53 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/574 ,  C07H21/02 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/47 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57438 ,  G01N33/57484

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BL172并从尿道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对泌尿道疾病和病症如尿道癌的倾向。 还提供了特异性结合BL172编码的多肽或蛋白质的抗体，以及预防组织特异性BL172多肽的作用的激动剂或抑制剂，该分子可用于治疗尿路疾病，肿瘤或转移瘤。

公开(公告)号：US06391543B2

公开(公告)日：2002-05-21

申请号：US09065383

申请日：1998-04-23

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS118并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS118编码的多肽或蛋白质的抗体，以及预防组织特异性PS118多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06252047B1

公开(公告)日：2001-06-26

申请号：US09525397

申请日：2000-03-15

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

IPC分类号： C07K1300

CPC分类号： C07K16/3069 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2500/04

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS108并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS108编码的多肽或蛋白质的抗体，以及预防组织特异性PS108多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06538119B2

公开(公告)日：2003-03-25

申请号：US09193881

申请日：1998-11-18

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS249 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS249-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS249 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

摘要翻译： 描述了一组由此编码的连续和部分重叠的cDNA序列和多肽，命名为BS249并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS249编码的多肽或蛋白质的抗体，以及预防组织特异性BS249多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

公开(公告)号：US06368792B1

公开(公告)日：2002-04-09

申请号：US09049698

申请日：1998-03-27

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US06183952B2

公开(公告)日：2001-02-06

申请号：US08912276

申请日：1997-08-15

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  Y10S435/81

摘要： A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了称为BU101的蛋白质的子宫肌血清蛋白家族的新成员。 BU101由一组从乳腺组织转录的连续和部分重叠的RNA序列以及由此编码的多肽来定义。 还公开了表示BU101的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：US06867016B1

公开(公告)日：2005-03-15

申请号：US09052855

申请日：1998-03-31

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K16/3046 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为CS141并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS141编码的多肽或蛋白质的抗体以及预防组织特异性CS141多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。

公开(公告)号：US06627414B2

公开(公告)日：2003-09-30

申请号：US09050516

申请日：1998-03-30

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12P2106

CPC分类号： G01N33/6893 ,  C07K14/47 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/06 ,  Y10S435/81 ,  Y10S530/828

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS 198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS 198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS 198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续的和部分重叠的cDNA序列和由此编码的多肽，命名为CS 198并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS 198编码的多肽或蛋白质的抗体以及预防组织特异性CS 198多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。