公开(公告)号：US06660834B2

公开(公告)日：2003-12-09

申请号：US10278547

申请日：2002-10-23

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07K1447

CPC分类号： G01N33/6893 ,  C07K14/47 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/06 ,  Y10S435/81 ,  Y10S530/828

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。

公开(公告)号：US6130043A

公开(公告)日：2000-10-10

申请号：US071710

申请日：1998-05-01

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

IPC分类号： A61K38/00 ,  C07K16/30 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K16/3069 ,  C12Q1/6886 ,  G01N33/57434 ,  A61K38/00 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：US06538119B2

公开(公告)日：2003-03-25

申请号：US09193881

申请日：1998-11-18

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS249 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS249-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS249 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

摘要翻译： 描述了一组由此编码的连续和部分重叠的cDNA序列和多肽，命名为BS249并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS249编码的多肽或蛋白质的抗体，以及预防组织特异性BS249多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

公开(公告)号：US06368792B1

公开(公告)日：2002-04-09

申请号：US09049698

申请日：1998-03-27

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US06465181B2

公开(公告)日：2002-10-15

申请号：US09276600

申请日：1999-03-25

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Julian Gordon ,  Edward N. Granados ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Julian Gordon ,  Edward N. Granados ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： G01N33/57434 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，称为PCIGF并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PCIGF编码的多肽或蛋白质的抗体，以及预防组织特异性PCIGF多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US07122653B2

公开(公告)日：2006-10-17

申请号：US10082659

申请日：2002-02-25

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H21/04 ,  C07H1/00 ,  C07H5/04 ,  C07H5/06 ,  C07H19/00

CPC分类号： G01N33/57434

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：US06350583B1

公开(公告)日：2002-02-26

申请号：US09566876

申请日：2000-05-08

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： G01N3353

CPC分类号： G01N33/57434

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS190并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS190编码的多肽或蛋白质的抗体，以及预防组织特异性PS190多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06232456B1

公开(公告)日：2001-05-15

申请号：US08944483

申请日：1997-10-06

申请人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

发明人： Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward Granados ,  Michael R. Klass ,  John C. Russell ,  Kent D. Stewart ,  Stephen D. Stroupe

IPC分类号： C12N1557

CPC分类号： C12N9/6424

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present invention is a member of the human serine protease family. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS133-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS133 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS133并从前列腺组织转录。 本发明的一种多肽是人丝氨酸蛋白酶家族的成员。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS133编码的多肽或蛋白质的抗体，以及预防组织特异性PS133多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US07282207B1

公开(公告)日：2007-10-16

申请号：US09549342

申请日：2000-04-13

申请人： Tracey L. Colpitts ,  John C. Russell

发明人： Tracey L. Colpitts ,  John C. Russell

IPC分类号： A61K39/00 ,  A61K39/385 ,  A61K38/00 ,  G01N33/53 ,  C07K2/00

CPC分类号： G01N33/57442

摘要： This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the uterus such as uterine cancer. Furthermore, the invention relates to methods and kits, for example, which utilize this antigen or an antibody thereto. The complex itself comprises at least one EU250 polypeptide and at least one polypeptide which may be a BU101 polypeptide and/or a TU104 polypeptide. The complex may further comprise other, as yet unknown, polypeptide sequences.

摘要翻译： 本发明一般涉及可用于检测或诊断子宫疾病如子宫癌的多聚体多肽复合物/抗原。 此外，本发明涉及例如利用该抗原或其抗体的方法和试剂盒。 复合物本身包含至少一种EU250多肽和至少一种可以是BU101多肽和/或TU104多肽的多肽。 复合物还可以包含其他尚未知的多肽序列。

公开(公告)号：US5624797A

公开(公告)日：1997-04-29

申请号：US472597

申请日：1995-06-07

申请人： Dominique P. Bridon ,  Isaac S.-Y. Sze, deceased ,  David J. Daghfal ,  Keeve D. Jaffe ,  Tracey L. Colpitts

发明人： Dominique P. Bridon ,  Isaac S.-Y. Sze, deceased ,  David J. Daghfal ,  Keeve D. Jaffe ,  Tracey L. Colpitts

摘要： HIV-1 peptides having at least one point mutation between position 593 and 611 of the HIV-1 gp160 amino acid sequence. The point mutation either is at position 604 or 610, or both positions. Immunoassays which utilize these peptides are provided, as well as, diagnostic test kits which contain these peptides.