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    Medical devices having laser brazed joints
    11.
    发明申请
    Medical devices having laser brazed joints 审中-公开
    具有激光钎焊接头的医疗器械

    公开(公告)号：US20060237407A1

    公开(公告)日：2006-10-26

    申请号：US11113768

    申请日：2005-04-25

    Applicant: Anh Nguyen ,  Samuel Robaina

    Inventor： Anh Nguyen ,  Samuel Robaina

    IPC: B23K1/005

    CPC classification number: B23K1/0056 ,  A61F2/90

    Abstract: A method is provided for forming a brazed joint between first and second elements of a medical device such as a stent. The method begins by forming a joint by positioning the first element with respect to the second element. A filler material is applied to the joint. An electromagnetic beam of energy is applied to the joint to at least partially melt the filler material.

    Abstract translation: 提供一种用于在诸如支架的医疗装置的第一和第二元件之间形成钎焊接头的方法。 该方法开始于通过相对于第二元件定位第一元件来形成接头。 将填料施加到接头上。 将电磁能量束施加到接头以至少部分地熔化填充材料。

    HIGH METAL TO VESSEL RATIO STENT AND METHOD
    12.
    发明申请
    HIGH METAL TO VESSEL RATIO STENT AND METHOD 有权
    高金属到船舶比例的方法和方法

    公开(公告)号：US20130261728A1

    公开(公告)日：2013-10-03

    申请号：US13430942

    申请日：2012-03-27

    Applicant: Keith PERKINS ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    Inventor： Keith PERKINS ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    IPC: A61F2/84 ,  A61F2/82

    CPC classification number: A61F2/915 ,  A61F2002/91525

    Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with a high metal to vessel ratio stent. A metal to vessel ratio of the high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the high metal to vessel ratio stent. The ingrowth of tissue provides secure fixation and sealing of the high metal to vessel ratio stent to the main vessel and remodels and essentially eliminates the aneurysm. Further, as the entire high metal to vessel ratio stent is permeably, the high metal to vessel ratio stent is deployed without having to rotationally position the high metal to vessel ratio stent.

    Abstract translation: 一种方法包括覆盖从主血管发出的分支血管和具有高金属与血管比例支架的动脉瘤。 高金属与血管比支架的金属与血管比例足够高以促使组织向内生长高金属与血管比例支架，但足够低以确保分支血管通过高金属与血管比例的支架灌注。 组织的向内生长提供了高金属与血管比例支架到主血管的牢固固定和密封，并且改造并且基本上消除了动脉瘤。 此外，随着整个高金属与血管比例的支架是可渗透的，高金属与血管比例的支架被展开，而不必旋转地定位高金属与血管比例的支架。

    Localized drug delivery using drug-loaded nanocapsules
    15.
    发明申请
    Localized drug delivery using drug-loaded nanocapsules 有权
    使用载药纳米胶囊的局部药物递送

    公开(公告)号：US20050129727A1

    公开(公告)日：2005-06-16

    申请号：US10768388

    申请日：2004-01-30

    Applicant: Jan Weber ,  Samuel Robaina

    Inventor： Jan Weber ,  Samuel Robaina

    IPC: A61F2/00 ,  A61K20060101 ,  A61K9/50 ,  A61K38/17 ,  A61K49/18 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61N1/00 ,  C12N9/99 ,  C12Q1/68

    CPC classification number: B82Y5/00 ,  A61F2210/009 ,  A61K9/5094 ,  A61K47/6923 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/624 ,  Y10S977/81 ,  Y10S977/906

    Abstract: Nanocapsules are disclosed which comprise (a) a drug-containing core and (b) a polyelectrolyte multilayer encapsulating the drug-containing core. The nanocapsules include particles whose largest dimension typically ranges between 50 nm to 10000 nm. In some embodiments, the nanocapsules contain a single drug. In others, the nanocapsules contain multiple drugs, either within the same nanocapsules or within separate populations of nanocapsules. In some embodiments, the nanocapsules comprise surfaces that are functionalized, for example, with ligands that allow for attachment to bodily tissue. In some embodiments of the present invention, the nanocapsules are rendered magnetic or are rendered susceptible to magnetic fields. Also disclosed is a drug delivery method that comprises the steps of (a) providing nanocapsules such as those above; and (b) placing the nanocapsules at a desired location within the body of a subject using an implantable or insertable medical device.

    Abstract translation: 公开了纳米胶囊，其包含（a）含药物核心和（b）包封药物核心的聚电解质多层。 纳米胶囊包括最大尺寸通常在50nm至10000nm之间的颗粒。 在一些实施方案中，纳米胶囊含有单一药物。 在其他方面，纳米胶囊含有多种药物，无论是在相同的纳米胶囊内还是在分开的纳米胶囊内。 在一些实施方案中，纳米胶囊包含官能化的表面，例如具有允许附着于身体组织的配体。 在本发明的一些实施方案中，纳米胶囊被磁化或变得易受磁场影响。 还公开了药物递送方法，其包括以下步骤：（a）提供如上所述的纳米胶囊; 和（b）使用可植入或可插入的医疗装置将纳米胶囊放置在受试者体内的期望位置。

    Stent design with variable expansion columns along circumference
    17.
    发明授权
    Stent design with variable expansion columns along circumference 有权
    支架设计与圆周可变膨胀柱

    公开(公告)号：US08236044B2

    公开(公告)日：2012-08-07

    申请号：US11749855

    申请日：2007-05-17

    Applicant: Samuel Robaina

    Inventor： Samuel Robaina

    IPC: A61F2/06

    CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0029

    Abstract: A stent comprises at least one curve deployment section. The at least one curve deployment section comprises at least one expansion ring having a circumferential length, a longitudinal length and comprising a first circumferential section and a second circumferential section. The first circumferential section comprises an expansion column and the second circumferential section comprises at least two expansion columns longitudinally offset from one another. The expansion column of the first circumferential section is engaged to the at least two expansion columns of the second circumferential section.

    Abstract translation: 支架包括至少一个曲线展开部分。 所述至少一个曲线展开部分包括至少一个具有圆周长度，纵向长度并包括第一圆周部分和第二圆周部分的膨胀环。 第一圆周部分包括膨胀柱，并且第二圆周部分包括彼此纵向偏移的至少两个膨胀塔。 第一周向部分的膨胀柱与第二圆周部分的至少两个膨胀柱接合。

    Mobile External Coupling with Internal Sealing Cuff for Branch Vessel Connection
    18.
    发明申请
    Mobile External Coupling with Internal Sealing Cuff for Branch Vessel Connection 有权
    用于分支船连接的内部密封袖口的移动外部耦合

    公开(公告)号：US20110270378A1

    公开(公告)日：2011-11-03

    申请号：US12770536

    申请日：2010-04-29

    Applicant: Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

    Inventor： Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

    IPC: A61F2/82

    CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2250/006

    Abstract: An endovascular prosthesis includes a tubular body and a mobile external coupling. The tubular body includes a graft material and stents coupled thereto, a forms a lumen therethrough. The mobile external coupling extends outwardly from the tubular body. The mobile external coupling includes a graft material and is generally frustoconically shaped. The mobile external coupling includes a base coupled to the tubular body, a top spaced from the tubular body, and a coupling lumen disposed between the base and the top, wherein the coupling lumen is in flow communication with the body lumen. A cylindrical sealing cuff of graft material is attached to and extends from the top of the mobile external coupling towards the tubular body within the coupling lumen. The sealing cuff is configured to contact a portion of a branch vessel prosthesis and thereby provides an elongated interference seal between the branch vessel prosthesis and the mobile external coupling.

    Abstract translation: 血管内假体包括管状主体和移动外部联接器。 管状体包括移植材料和与其连接的支架，a形成通过其中的腔。 移动外部联接件从管状体向外延伸。 移动外部联接件包括移植材料并且通常是截头圆锥形的。 移动外部联接器包括联接到管状体的基部，与管状体间隔开的顶部以及设置在基部和顶部之间的联接腔，其中联接腔与体腔流动连通。 移植材料的圆柱形密封套连接到移动外部联接器的顶部并且在联接腔内朝向管状体延伸。 密封套构造成接触分支血管假体的一部分，从而在分支血管假体和移动外部联接器之间提供细长的干涉密封。

    DRUG-ELUTING STENT
    20.
    发明申请
    DRUG-ELUTING STENT 失效
    药物治疗

    公开(公告)号：US20100023115A1

    公开(公告)日：2010-01-28

    申请号：US12178180

    申请日：2008-07-23

    Applicant: Samuel Robaina ,  Cory Hitzman ,  Kim Robertson ,  Liza Davis ,  Jason T. Lenz

    Inventor： Samuel Robaina ,  Cory Hitzman ,  Kim Robertson ,  Liza Davis ,  Jason T. Lenz

    IPC: A61F2/06

    CPC classification number: A61F2/915 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0068

    Abstract: A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.

    Abstract translation: 用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。 至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。 所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。 每个井区域定义具有深度的井。 至少一些孔含有治疗剂。

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