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    High metal to vessel ratio stent and method
    5.
    发明授权
    High metal to vessel ratio stent and method 有权
    高金属与血管比支架和方法

    公开(公告)号：US09005270B2

    公开(公告)日：2015-04-14

    申请号：US13430942

    申请日：2012-03-27

    申请人： Keith Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    发明人： Keith Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    IPC分类号： A61F2/82 ,  A61F2/915

    CPC分类号： A61F2/915 ,  A61F2002/91525

    摘要： A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with a high metal to vessel ratio stent. A metal to vessel ratio of the high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the high metal to vessel ratio stent. The ingrowth of tissue provides secure fixation and sealing of the high metal to vessel ratio stent to the main vessel and remodels and essentially eliminates the aneurysm. Further, as the entire high metal to vessel ratio stent is permeably, the high metal to vessel ratio stent is deployed without having to rotationally position the high metal to vessel ratio stent.

    摘要翻译： 一种方法包括覆盖从主血管发出的分支血管和具有高金属与血管比例支架的动脉瘤。 高金属与血管比支架的金属与血管比例足够高以促使组织向内生长高金属与血管比例支架，但足够低以确保分支血管通过高金属与血管比例的支架灌注。 组织的向内生长提供了高金属与血管比例支架到主血管的牢固固定和密封，并且改造并且基本上消除了动脉瘤。 此外，随着整个高金属与血管比例的支架是可渗透的，高金属与血管比例的支架被展开，而不必旋转地定位高金属与血管比例的支架。

    Localized drug delivery using drug-loaded nanocapsules
    7.
    发明授权
    Localized drug delivery using drug-loaded nanocapsules 有权
    使用载药纳米胶囊的局部药物递送

    公开(公告)号：US07767219B2

    公开(公告)日：2010-08-03

    申请号：US10768388

    申请日：2004-01-30

    申请人： Jan Weber ,  Samuel Robaina

    发明人： Jan Weber ,  Samuel Robaina

    IPC分类号： A61F2/82

    CPC分类号： B82Y5/00 ,  A61F2210/009 ,  A61K9/5094 ,  A61K47/6923 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/624 ,  Y10S977/81 ,  Y10S977/906

    摘要： Nanocapsules are disclosed which comprise (a) a drug-containing core and (b) a polyelectrolyte multilayer encapsulating the drug-containing core. The nanocapsules include particles whose largest dimension typically ranges between 50 nm to 10000 nm. In some embodiments, the nanocapsules contain a single drug. In others, the nanocapsules contain multiple drugs, either within the same nanocapsules or within separate populations of nanocapsules. In some embodiments, the nanocapsules comprise surfaces that are functionalized, for example, with ligands that allow for attachment to bodily tissue. In some embodiments of the present invention, the nanocapsules are rendered magnetic or are rendered susceptible to magnetic fields. Also disclosed is a drug delivery method that comprises the steps of (a) providing nanocapsules such as those above; and (b) placing the nanocapsules at a desired location within the body of a subject using an implantable or insertable medical device.

    摘要翻译： 公开了纳米胶囊，其包含（a）含药物核心和（b）包封药物核心的聚电解质多层。 纳米胶囊包括最大尺寸通常在50nm至10000nm之间的颗粒。 在一些实施方案中，纳米胶囊含有单一药物。 在其他方面，纳米胶囊含有多种药物，无论是在相同的纳米胶囊内还是在分开的纳米胶囊内。 在一些实施方案中，纳米胶囊包含官能化的表面，例如具有允许附着于身体组织的配体。 在本发明的一些实施方案中，纳米胶囊被磁化或变得易受磁场影响。 还公开了药物递送方法，其包括以下步骤：（a）提供如上所述的纳米胶囊; 和（b）使用可植入或可插入的医疗装置将纳米胶囊放置在受试者体内的期望位置。

    Stent Design with Variable Expansion Columns along Circumference
    8.
    发明申请
    Stent Design with Variable Expansion Columns along Circumference 有权
    支架设计与可变扩展列沿周长

    公开(公告)号：US20080004690A1

    公开(公告)日：2008-01-03

    申请号：US11749855

    申请日：2007-05-17

    申请人： Samuel Robaina

    发明人： Samuel Robaina

    IPC分类号： A61F2/82

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0029

    摘要： A stent comprises at least one curve deployment section. The at least one curve deployment section comprises at least one expansion ring having a circumferential length, a longitudinal length and comprising a first circumferential section and a second circumferential section. The first circumferential section comprises an expansion column and the second circumferential section comprises at least two expansion columns longitudinally offset from one another. The expansion column of the first circumferential section is engaged to the at least two expansion columns of the second circumferential section.

    摘要翻译： 支架包括至少一个曲线展开部分。 所述至少一个曲线展开部分包括至少一个具有圆周长度，纵向长度并包括第一圆周部分和第二圆周部分的膨胀环。 第一圆周部分包括膨胀柱，并且第二圆周部分包括彼此纵向偏移的至少两个膨胀塔。 第一周向部分的膨胀柱与第二圆周部分的至少两个膨胀柱接合。

    INTEGRATED MESH HIGH METAL TO VESSEL RATIO STENT AND METHOD
    9.
    发明申请
    INTEGRATED MESH HIGH METAL TO VESSEL RATIO STENT AND METHOD 有权
    一体化高金属到船舶比例的方法和方法

    公开(公告)号：US20130261732A1

    公开(公告)日：2013-10-03

    申请号：US13431732

    申请日：2012-03-27

    申请人： Kieth Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    发明人： Kieth Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

    IPC分类号： A61F2/82 ,  C23F1/02 ,  B23K26/00

    CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/061 ,  A61F2240/001

    摘要： A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with an integrated mesh high metal to vessel ratio stent. The integrated mesh high metal to vessel ratio stent includes serpentine rings integrated with an integrated mesh having holes formed therein. A metal to vessel ratio of the integrated mesh high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the integrated mesh high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the integrated mesh high metal to vessel ratio stent.

    摘要翻译： 一种方法包括覆盖从主血管发出的分支血管和具有整合的网状高金属比血管支架的动脉瘤。 集成网格高金属与容器比例支架包括与其中形成有孔的整体网格集成的蛇形环。 一体化网状高金属与血管比例支架的金属与血管比例足够高，以促进组合网格高金属与血管比支架之间的组织向内生长，但足够低以确保分支血管通过整体网格高金属的灌注至 血管比例支架。

    Mobile external coupling with internal sealing cuff for branch vessel connection
    10.
    发明授权
    Mobile external coupling with internal sealing cuff for branch vessel connection 有权
    用于分支器皿连接的内部密封套的移动外部联接

    公开(公告)号：US08333800B2

    公开(公告)日：2012-12-18

    申请号：US12770536

    申请日：2010-04-29

    申请人： Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

    发明人： Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2250/006

    摘要： An endovascular prosthesis includes a tubular body and a mobile external coupling. The tubular body includes a graft material and stents coupled thereto, a forms a lumen therethrough. The mobile external coupling extends outwardly from the tubular body. The mobile external coupling includes a graft material and is generally frustoconically shaped. The mobile external coupling includes a base coupled to the tubular body, a top spaced from the tubular body, and a coupling lumen disposed between the base and the top, wherein the coupling lumen is in flow communication with the body lumen. A cylindrical sealing cuff of graft material is attached to and extends from the top of the mobile external coupling towards the tubular body within the coupling lumen. The sealing cuff is configured to contact a portion of a branch vessel prosthesis and thereby provides an elongated interference seal between the branch vessel prosthesis and the mobile external coupling.

    摘要翻译： 血管内假体包括管状主体和移动外部联接器。 管状体包括移植材料和与其连接的支架，a形成通过其中的腔。 移动外部联接件从管状体向外延伸。 移动外部联接件包括移植材料并且通常是截头圆锥形的。 移动外部联接器包括联接到管状体的基部，与管状体间隔开的顶部以及设置在基部和顶部之间的联接腔，其中联接腔与体腔流动连通。 移植材料的圆柱形密封套连接到移动外部联接器的顶部并且在联接腔内朝向管状体延伸。 密封套构造成接触分支血管假体的一部分，从而在分支血管假体和移动外部联接器之间提供细长的干涉密封。