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37 条记录 (耗时 0.028 秒)

    Ex vivo methods for testing toxicity of substances using donated human organs or tissues
    11.
    发明授权
    Ex vivo methods for testing toxicity of substances using donated human organs or tissues 有权
    使用捐赠的人体器官或组织测试物质毒性的离体方法

    公开(公告)号：US08771930B2

    公开(公告)日：2014-07-08

    申请号：US11802059

    申请日：2007-05-18

    申请人： Gerald Curtis ,  John Brassil ,  David Kravitz

    发明人： Gerald Curtis ,  John Brassil ,  David Kravitz

    IPC分类号： A01N1/00

    CPC分类号： G01N33/5082 ,  G01N33/5014 ,  G01N33/566 ,  G01N33/574 ,  G01N33/68 ,  G06Q20/102

    摘要： Properties such as toxicity of substances may be determined by assaying properties, fates and effects of substances in an ex vivo metabolically active human organ or tissue under normothermic perfusion with a fluid containing a test substance. The data can be used as, for example, part of a submission to a government regulatory organization. Preferred methods use perfused endocrine gland organs or tissues to evaluate hormone or other bodily chemical disruption caused by substances and pre-donation diseased or injured organs or tissues.

    摘要翻译： 诸如物质的毒性的物质可以通过使用含有测试物质的流体在正常温度灌注下测定离体代谢活性人器官或组织中物质的性质，命运和作用来确定。 数据可以用作例如向政府监管机构提交的一部分。 优选的方法使用灌注的内分泌腺器官或组织来评估由物质和预先捐赠的患病或受伤的器官或组织引起的激素或其他身体化学物质的破坏。

    Living Donor Cannula
    12.
    发明申请
    Living Donor Cannula 有权
    生活捐助者插管

    公开(公告)号：US20120277681A1

    公开(公告)日：2012-11-01

    申请号：US13283166

    申请日：2011-10-27

    申请人： David Kravitz ,  Christopher Steinman ,  David Pettinato

    发明人： David Kravitz ,  Christopher Steinman ,  David Pettinato

    IPC分类号： A61M25/04

    CPC分类号： A61B17/122 ,  A61B2017/00907 ,  A61B2017/00969

    摘要： A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.

    摘要翻译： 套管包括第一周向部分，第二周向部分和具有第一夹紧表面的密封件。 第一周向部分和第二周向部分被构造成相互配合以支撑脉管的周边，并且形成第二夹紧表面。 第一夹紧表面和第二夹紧表面被配置成协作以固定脉管系统的端部。

    Products, systems and methods for teaching educational subjects to young children
    14.
    发明申请
    Products, systems and methods for teaching educational subjects to young children 审中-公开
    用于向幼儿教授教育科目的产品，系统和方法

    公开(公告)号：US20060057546A1

    公开(公告)日：2006-03-16

    申请号：US11089552

    申请日：2005-03-25

    申请人： David Kravitz ,  Mary Maunz

    发明人： David Kravitz ,  Mary Maunz

    IPC分类号： G09B19/00 ,  G09B1/00

    CPC分类号： G09B5/04 ,  G09B19/04 ,  G09B19/06

    摘要： Products, methods and systems for teaching various educational subjects, such as reading, mathematics, music, geography, to young children. In one exemplary embodiment, a method for teaching beginning reading to a beginning reader in a classroom setting, includes (a) providing one or more of a picture or game to a beginning reader, the one or more of a picture or game including a pictorial representation of a first learning object, (b) pronouncing to the beginning reader the picture or game, the pronouncing emphasizing with intonation single sound phonetically representative of the beginning letter of the object displayed on the picture or game. The method also includes repeating steps (a) and (b) to the student for a plurality of pictures or games having pictorial representations of objects other than the first learning object. The method further includes the step of asking the beginning reader to name the object, the student pronouncing with exaggerated intonation the single sound phonetically representative of the beginning letter of the object on the picture or game, and determining whether the beginning reader correctly pronounced the beginning letter.

    摘要翻译： 用于教育各种教育科目的产品，方法和系统，如阅读，数学，音乐，地理，幼儿。 在一个示例性实施例中，一种用于在课室设置中开始阅读的教学方法包括：（a）向起始读者提供图片或游戏中的一个或多个，包括图形的图片或游戏中的一个或多个 第一个学习对象的表示，（b）向开始读者发送图片或游戏，发音强调用语音单词声音代表在图片或游戏上显示的对象的开始字母。 该方法还包括对具有第一学习对象以外的对象的图形表示的多个图片或游戏对学生重复步骤（a）和（b）。 该方法还包括要求开始读者命名对象的步骤，学生用夸张的语调来发音，单词在图片或游戏上以声音代表对象的起始字母，并且确定开头的阅读者是否正确地发音开始 信。

    Temperature sensing in organ preservation apparatus
    15.
    发明授权
    Temperature sensing in organ preservation apparatus 有权

    公开(公告)号：US11439143B2

    公开(公告)日：2022-09-13

    申请号：US13545473

    申请日：2012-07-10

    申请人： David Kravitz ,  Christopher P. Steinman ,  David Pettinato ,  Richard K. Buck ,  John Stark ,  Robert J. Allen

    发明人： David Kravitz ,  Christopher P. Steinman ,  David Pettinato ,  Richard K. Buck ,  John Stark ,  Robert J. Allen

    IPC分类号： A01N1/02

    摘要： A temperature sensor for monitoring an organ or tissue is configured to measure a temperature inside of a container configured to contain the organ or tissue. The temperature sensor is disposed exterior to the organ container and the temperature sensor is a non-contact temperature sensor. The temperature sensor may be part of an apparatus for perfusing, transporting, and/or storing an organ or tissue. A coolant container may have an aperture through which the temperature sensor measures a temperature of at least one of the organ or tissue or a perfusate fluid surrounding the organ or tissue. The temperature sensor is preferably an infrared temperature sensor. Multiple temperature sensors may be provided that measure the temperature organ or tissue or perfusate fluid surrounding the organ or tissue, for example in case one of the temperature sensors fails.

    Methods for increasing isolation yields of cellular products
    16.
    发明授权
    Methods for increasing isolation yields of cellular products 有权

    公开(公告)号：US09834756B2

    公开(公告)日：2017-12-05

    申请号：US13183961

    申请日：2011-07-15

    申请人： Michael J. Taylor ,  Simona C. Baicu ,  David Kravitz

    发明人： Michael J. Taylor ,  Simona C. Baicu ,  David Kravitz

    IPC分类号： C12N5/071 ,  A01N1/02

    CPC分类号： C12N5/0676 ,  A01N1/0247

    摘要： Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.

    Ex vivo methods for validating substance testing with human organs and/or tissues
    18.
    发明授权
    Ex vivo methods for validating substance testing with human organs and/or tissues 有权
    用于人体器官和/或组织验证物质测试的离体方法

    公开(公告)号：US08765364B2

    公开(公告)日：2014-07-01

    申请号：US11802064

    申请日：2007-05-18

    申请人： Gerald Curtis ,  John Brassil ,  David Kravitz

    发明人： Gerald Curtis ,  John Brassil ,  David Kravitz

    IPC分类号： A01N1/00

    CPC分类号： G01N33/5088 ,  G06Q50/22

    摘要： Methods of validating results of assessments of test substances using human-derived tissues and/or organs, particularly tissues and/or organs unsuitable for transplantation, include assessing the suitability of the organ and/or tissue for substance testing, as well as inter-organ variability and use of exogenous and/or endogenous controls.

    摘要翻译： 使用人来源的组织和/或器官，特别是不适合移植的组织和/或器官验证测试物质的评估结果的方法包括评估器官和/或组织用于物质测试以及器官间的适合性 外源和/或内源对照的变异性和使用。

    WORK REQUEST PROCESSOR
    19.
    发明申请
    WORK REQUEST PROCESSOR 有权

    公开(公告)号：US20130111000A1

    公开(公告)日：2013-05-02

    申请号：US13285773

    申请日：2011-10-31

    申请人： David Kravitz ,  Daniel E. Dever ,  Wilson P. Snyder, II

    发明人： David Kravitz ,  Daniel E. Dever ,  Wilson P. Snyder, II

    IPC分类号： G06F15/173

    CPC分类号： G06F9/5083 ,  G06F9/4881 ,  G06F9/50 ,  H04L49/90

    摘要： A network processor includes a schedule, sync and order (SSO) module for scheduling and assigning work to multiple processors. The SSO includes an on-deck unit (ODU) that provides a table having several entries, each entry storing a respective work queue entry, and a number of lists. Each of the lists may be associated with a respective processor configured to execute the work, and includes pointers to entries in the table. A pointer is added to the list based on an indication of whether the associated processor accepts the WQE corresponding to the pointer.