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公开(公告)号：US10077272B2
公开(公告)日：2018-09-18
申请号：US15822493
申请日：2017-11-27
Applicant: PFIZER INC.
Inventor： David Lawrence Firman Gray , Lei Zhang , Jennifer Elizabeth Davoren , Amy Beth Dounay , Ivan Viktorovich Efremov , Chewah Lee , Scot Richard Mente , Steven Victor O'Neil , Bruce Nelsen Rogers , Chakrapani Subramanyam
IPC: C07D471/04 , C07D491/048 , C07D498/04
CPC classification number: C07D491/048 , C07D471/04 , C07D498/04
Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.
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公开(公告)号：US09868744B2
公开(公告)日：2018-01-16
申请号：US15305372
申请日：2015-04-13
Applicant: PFIZER INC.
Inventor： David Lawrence Firman Gray , Lei Zhang , Jennifer Elizabeth Davoren , Amy Beth Dounay , Ivan Viktorovich Efremov , Chewah Lee , Scot Richard Mente , Steven Victor O'Neil , Bruce Nelsen Rogers , Chakrapani Subramanyam
IPC: C07D471/04 , C07D491/048 , C07D498/04
CPC classification number: C07D491/048 , C07D471/04 , C07D498/04
Abstract: The present invention provides, in part, compounds of Formula (I) and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.
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公开(公告)号：US09764040B2
公开(公告)日：2017-09-19
申请号：US15280563
申请日：2016-09-29
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K47/48 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/351 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501 , A61K31/35 , A61K31/4025
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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公开(公告)号：US09249186B2
公开(公告)日：2016-02-02
申请号：US14793942
申请日：2015-07-08
Applicant: PFIZER INC.
Inventor： Matthew David Doroski , Andreas Maderna , Christopher John O'Donnell , Chakrapani Subramanyam , Beth Vetelino , Russell George Dushin , Pavel Strop , Edmund Idris Graziani
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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公开(公告)号：US09138486B2
公开(公告)日：2015-09-22
申请号：US14322262
申请日：2014-07-02
Applicant: PFIZER INC.
Inventor： Matthew David Doroski , Andreas Maderna , Christopher John O'Donnell , Chakrapani Subramanyam , Beth Vetelino , Russell George Dushin , Pavel Strop , Edmund Idris Graziani
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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Patent Agency Ranking
![Novel Pyrido[1,2-a]Pryazines And Their Use In The Treatment of Neurodegenerative and Neurological Disorders](/abs-image/US/2015/03/12/US20150072990A1/abs.jpg.150x150.jpg)
16.发明申请Novel Pyrido[1,2-a]Pryazines And Their Use In The Treatment of Neurodegenerative and Neurological Disorders 审中-公开新型吡啶并[1,2-a] Pryazine及其用于治疗神经退行性和神经性疾病公开(公告)号：US20150072990A1
公开(公告)日：2015-03-12
申请号：US14543020
申请日：2014-11-17
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：US20240409573A1
公开(公告)日：2024-12-12
申请号：US18627949
申请日：2024-04-05
Applicant: PFIZER INC.
Inventor： Omar Khaled Ahmad , Stephen Paul Brown , Kenneth John Dirico , Russell Dushin , Gary Frederick Filzen , Sujiet Puthenveetil , Pavel Strop , Chakrapani Subramanyam , Lawrence N. Tumey
Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
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公开(公告)号：US11833216B2
公开(公告)日：2023-12-05
申请号：US18166774
申请日：2023-02-09
Applicant: Pfizer Inc.
Inventor： Andrea Therese Hooper , Kimberly Ann Marquette , Chakrapani Subramanyam , Hans-Peter Gerber , Chad Michael May
CPC classification number: A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/92
Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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![Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders](/abs-image/US/2017/09/05/US09751877B2/abs.jpg.150x150.jpg)
19.发明授权公开(公告)号：US09751877B2
公开(公告)日：2017-09-05
申请号：US14877118
申请日：2015-10-07
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：US09504669B2
公开(公告)日：2016-11-29
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K31/351 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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