中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

40 records (took 0.038 seconds)

    COMPOSITIONS AND METHODS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN
    11.
    发明申请
    COMPOSITIONS AND METHODS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN 审中-公开
    组合物和方法相关的突变体分离毒素

    公开(公告)号：US20150291940A1

    公开(公告)日：2015-10-15

    申请号：US14436875

    申请日：2013-10-07

    Applicant: PFIZER INC.

    Inventor： Jason Arnold Lotvin ,  Annaliesa Sybil Anderson ,  Robert G. K. Donald ,  Michael James Flint ,  Narender Kumar Kalyan ,  Kathrin Ute Jansen ,  Maninder K. Sidhu ,  Justin Keith Moran ,  Mark Edward Ruppen ,  Weiqiang Sun

    IPC: C12N9/10

    Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

    Abstract translation: 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。突变毒素可以包括具有至少一个突变的葡糖基转移酶结构域和至少具有至少一个突变的半胱氨酸蛋白酶结构域 一个突变，相对于相应的野生型艰难梭菌毒素。 突变毒素可以包括至少一个化学交联的氨基酸。 另一方面，本发明涉及用于培养艰难梭菌和产生艰难梭菌毒素的方法和组合物。

    NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOF
    19.
    发明申请
    NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOF 审中-公开
    NEISSERIA MENINGITIDIS组合物及其方法

    公开(公告)号：US20160347797A1

    公开(公告)日：2016-12-01

    申请号：US15237005

    申请日：2016-08-15

    Applicant: PFIZER INC.

    Inventor： Annaliesa Sybil Anderson ,  Susan Kay Hoiseth ,  Kathrin Ute Jansen ,  Justin Keith Moran ,  Mark E. Ruppen

    IPC: C07K14/22 ,  A61K39/095

    CPC classification number: A61K39/095 ,  A61K2039/55577 ,  A61K2039/6018 ,  C07K14/22 ,  C07K16/1217

    Abstract: In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 68. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal

    Abstract translation: 一方面，本发明涉及分离的多肽，其包含与SEQ ID NO：68具有至少95％同一性的氨基酸序列。另一方面，本发明涉及免疫原性组合物，其包含分离的非脂化非 - 来自脑膜炎奈瑟氏球菌血清群B的丙酮酸化的ORF2086多肽和来自脑膜炎球菌的至少一种共轭荚膜糖

    NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF
    20.
    发明申请
    NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF 有权
    NEISSERIA MENINGITIDIS组合物及其方法

    公开(公告)号：US20130243807A1

    公开(公告)日：2013-09-19

    申请号：US13787594

    申请日：2013-03-06

    Applicant: PFIZER INC.

    Inventor： Annaliesa Sybil Anderson ,  Susan Kay Hoiseth ,  Kathrin Ute Jansen ,  Justin Keith Moran ,  Mark E. Ruppen

    IPC: A61K39/095 ,  C07K14/22

    CPC classification number: A61K39/095 ,  A61K2039/55577 ,  A61K2039/6018 ,  C07K14/22 ,  C07K16/1217

    Abstract: In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup.

    Abstract translation: 一方面，本发明涉及包含与SEQ ID NO：71具有至少95％同一性的氨基酸序列的分离多肽。另一方面，本发明涉及免疫原性组合物，其包含分离的非脂化非 - 来自脑膜炎奈瑟氏球菌血清群B的丙酮酸化ORF2086多肽和来自脑膜炎球菌血清群的至少一种共轭荚膜糖。

Patent Agency Ranking