公开(公告)号：US20050276757A1

公开(公告)日：2005-12-15

申请号：US11128106

申请日：2005-05-11

申请人： Jocelyn Wright ,  Victoria Sung ,  Michel Faure ,  Elizabeth Blackwood

发明人： Jocelyn Wright ,  Victoria Sung ,  Michel Faure ,  Elizabeth Blackwood

IPC分类号： A61K49/00 ,  A61P35/00 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/485 ,  A61K49/0004 ,  G01N33/574 ,  G01N2500/02 ,  G01N2800/52

摘要： The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a compound modulates ZC1 or ZC3 kinase activity, methods of determining whether a mammal is responding to a compound that modulates ZC1 or ZC3 kinase activity, and methods of predicting whether a mammal will respond therapeutically to a method of treating cancer by administering a modulator of ZC1 or ZC3 kinase.

摘要翻译： 本发明提供新的癌症生物标志物：ZC1和/或ZC3激酶底物的磷酸化，特别是p120连环蛋白和Abi-1。 因此，本发明提供了确定化合物是否调节ZC1或ZC3激酶活性的方法，确定哺乳动物是否对调节ZC1或ZC3激酶活性的化合物作出反应的方法以及预测哺乳动物是否会对方法进行治疗的方法 通过施用ZC1或ZC3激酶的调节剂治疗癌症。

公开(公告)号：US5886311A

公开(公告)日：1999-03-23

申请号：US927928

申请日：1997-09-11

申请人： Robert Morel ,  Henri Auque ,  Philippe Hartmann ,  Denis Vial ,  Michel Faure

发明人： Robert Morel ,  Henri Auque ,  Philippe Hartmann ,  Denis Vial ,  Michel Faure

IPC分类号： H01H1/36 ,  H01H3/40 ,  H01H9/00 ,  H01H19/64 ,  H01H21/18 ,  H01H21/42 ,  H01H3/32

CPC分类号： H01H21/18 ,  H01H19/64 ,  H01H9/0072 ,  H01H1/2041 ,  H01H1/365 ,  H01H2071/1036 ,  H01H21/42 ,  H01H3/40

摘要： A multipole switch comprises a plurality of single-pole switch modules arranged side by side in compartments of the insulating case. Each switch module comprises an individual switching bar supporting the movable contact, said bar being formed by a vertical-axis rotary insulating stud having an end-piece for guiding in rotation at one of its ends, and driving means at the other end. A pair of actuating rods is mechanically coupled to the driving means of all the switching bars, and cooperates with connecting rods of the operating mechanism to perform movement of the actuating rods in translation in opposite directions when moving from the open position to the closed position, and vice-versa, said elongate actuating rods extending parallel to one another in a horizontal plane perpendicular to the different rotary studs.

摘要翻译： 多极开关包括在绝缘壳体的隔室中并排布置的多个单极开关模块。 每个开关模块包括支撑可动触头的单独的开关杆，所述杆由垂直轴旋转绝缘支柱形成，所述垂直轴旋转绝缘支架具有用于在其一端引导旋转的端件和另一端的驱动装置。 一对致动杆机械联接到所有切换杆的驱动装置，并且与操作机构的连接杆配合，以在从打开位置移动到关闭位置时沿相反方向平移的致动杆的运动， 并且反之亦然，所述细长致动杆在垂直于不同旋转螺柱的水平面中彼此平行延伸。

公开(公告)号：US4465325A

公开(公告)日：1984-08-14

申请号：US415348

申请日：1982-09-07

申请人： Michel Faure ,  Jean-Louis Poinssot

发明人： Michel Faure ,  Jean-Louis Poinssot

IPC分类号： F16C29/02 ,  G21C19/02 ,  F16C32/06 ,  G21C19/00

CPC分类号： F16C32/06 ,  F16C29/025 ,  G21C19/02

摘要： The present invention relates to a device for handling a load, particularly an immersed load, by means of a shaft having a polygonal cross-section.The shaft, which can move along its axis, is maintained by a bearing connected to rotation means, so that a rotation of the bearing about the axis of the shaft leads to an identical rotation of the latter. The supply fluid for the bearing can be that in which the load to be manipulated is immersed.Application to the control and inspection of fuel rods.

摘要翻译： 本发明涉及一种用于通过具有多边形横截面的轴来处理负载，特别是浸入式负载的装置。 可以沿其轴线移动的轴由连接到旋转装置的轴承保持，使得轴承围绕轴的轴线的旋转导致其相同的旋转。 用于轴承的供应流体可以是要操纵的负载被浸没的供应流体。 应用于燃料棒的控制和检查。

公开(公告)号：US4457770A

公开(公告)日：1984-07-03

申请号：US364251

申请日：1982-04-01

申请人： Michel Faure ,  Yves Lumineau ,  Andre Jouanin

发明人： Michel Faure ,  Yves Lumineau ,  Andre Jouanin

IPC分类号： C03B37/018 ,  C03B37/025

CPC分类号： C03B37/01807

摘要： The invention relates to an apparatus for producing a preform for constituting an optical fiber. This apparatus essentially comprises a glass maker's lathe and a motor which holds and rotates a hollow silica tube, a torch making it possible to heat a cross-section of the tube and which can be translated along the tube and means for supplying the gaseous compounds consisting of silicon chloride, oxygen and doping agents decomposing under the action of the heat. Part of the products obtained is deposited on the walls of the tube. The supply means comprise a pipe entering the tube in axial manner and at the end of which are provided two radially directed arms, which terminate with an outlet normal to the pipe and arm, said pipe moving in translation integrally with the torch.

摘要翻译： 本发明涉及一种用于制造用于构成光纤的预成型件的设备。 该设备基本上包括玻璃制造商的车床和电动机，其保持和旋转中空二氧化硅管，火炬使得可以加热管的横截面并且可以沿着管平移并且用于供应气态化合物的装置 的氯化硅，氧气和掺杂剂在热的作用下分解。 获得的部分产品沉积在管的壁上。 供应装置包括以轴向方式进入管的管，并且其末端设置有两个径向指向的臂，其终止于与管和臂垂直的出口，所述管与火炬一体地移动。

公开(公告)号：US4249924A

公开(公告)日：1981-02-10

申请号：US42785

申请日：1979-05-29

申请人： Arnaud de Panafieu ,  Christiane Baylac ,  Yves Nemaud ,  Marc Turpin ,  Michel Faure

发明人： Arnaud de Panafieu ,  Christiane Baylac ,  Yves Nemaud ,  Marc Turpin ,  Michel Faure

IPC分类号： C03B37/014 ,  C03C3/089 ,  C03C13/04 ,  C03C15/00 ,  C03C23/00 ,  G02B6/00 ,  G02B6/028 ,  C03B37/00 ,  C03B32/00

CPC分类号： G02B6/0281 ,  C03C13/045 ,  C03C13/046 ,  C03C15/00 ,  C03C23/008

摘要： A process for the manufacture of a glass blank in the form of a rod from which the optical fibre is drawn, said blank being produced starting from a molten bath of glass. A first stage of the process comprises melting a mixture of starting materials having a higher impurity content (

摘要翻译： 一种用于制造呈玻璃形状的玻璃坯料的方法，从该玻璃坯料中拉出光纤，所述坯料从玻璃熔池开始产生。 该方法的第一阶段包括将所谓的过渡金属形式的杂质含量（<10-4）的原料混合物熔化成最后的坯料（<10-7）。 第二阶段是通过从熔融玻璃浴中抽出坯料并随后对其进行热退火处理，从而诱导分离成两个固相（富含二氧化硅的硬相和二氧化硅中的软相）。 接下来是深蚀刻和周边蚀刻，以消除作为深度的函数的不同程度的软相和其杂质，产生径向折射率梯度和光学包层。

公开(公告)号：US20140005070A1

公开(公告)日：2014-01-02

申请号：US14004623

申请日：2012-03-28

申请人： Michel Faure ,  Zhenhai Gao ,  James Sutton ,  Guoying Karen Yu

发明人： Michel Faure ,  Zhenhai Gao ,  James Sutton ,  Guoying Karen Yu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5023 ,  G01N2800/52

摘要： The invention provides methods of monitoring differential gene expression of pharmacodynamic (PD) markers in a patient treated with a Cyclin Dependent Kinase Inhibitor (CDKI), methods of determining the sensitivity of a cell to a CDKI by measuring PD markers and methods of screening for candidate CKDI.

摘要翻译： 本发明提供了在用细胞周期蛋白依赖性激酶抑制剂（CDKI）治疗的患者中监测药效学（PD）标记物的差异基因表达的方法，通过测量PD标志物来测定细胞对CDKI的敏感性的方法和筛选候选物质的方法 CKDI。

公开(公告)号：US20100009392A1

公开(公告)日：2010-01-14

申请号：US12375074

申请日：2007-07-26

申请人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

发明人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

IPC分类号： G01N33/53

CPC分类号： A61K31/4439 ,  A61K31/44 ,  A61K31/496 ,  G01N33/5743 ,  G01N2333/4704 ,  G01N2500/10

摘要： The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent.

摘要翻译： 本发明提供了一种确定具有黑素瘤肿瘤细胞的哺乳动物受试者用黑素瘤抑制剂治疗的反应的方法。 一方面，该方法包括：（a）在用黑素瘤抑制剂处理之前，从取自哺乳动物受试者的第一生物样品中确定黑素瘤抑制活性蛋白（MIA）的第一浓度; （b）在用黑素瘤抑制剂处理后，确定来自哺乳动物受试者的第二生物样品中MIA的第二浓度; 和（c）比较第一和第二浓度的MIA，其中在第二生物样品中测量的MIA的第二浓度的降低与在第一生物样品中测量的MIA的第一浓度相比表明对于用 黑素瘤抑制剂。

公开(公告)号：US06265685B1

公开(公告)日：2001-07-24

申请号：US09453033

申请日：1999-12-02

申请人： Michel Faure ,  François Sirolli ,  Serge Terpend

发明人： Michel Faure ,  François Sirolli ,  Serge Terpend

IPC分类号： H01H3304

CPC分类号： H01H1/2041 ,  H01H9/44 ,  H01H9/443

摘要： A switch comprises a long, slender stationary contact means and a movable contact means moving between an open position and a closed position. The contact zone of the contact means is separated from the electrical connection zone by a slot which opens out on the side where the movable contact means are situated in the open position. The depth of the slot is sufficient so that, when opening takes place, the current lines passing through the contact means are curved and run approximately parallel to the flank of the slot. This arrangement prevents the foot of the electrical arc from being directed towards the free end of the contact means, away from the arc extinguishing chamber.

摘要翻译： 开关包括长而细长的固定接触装置和在打开位置和关闭位置之间移动的可动接触装置。 接触装置的接触区域通过在可动接触装置位于打开位置的一侧开口的槽与电连接区分开。 槽的深度足以使得当打开时，通过接触装置的电流线弯曲并且大致平行于槽的侧面延伸。 这种布置防止电弧的脚部朝向灭弧室远离接触装置的自由端。

公开(公告)号：US4415874A

公开(公告)日：1983-11-15

申请号：US279648

申请日：1981-07-02

申请人： Gerard Messe ,  Michel Faure

发明人： Gerard Messe ,  Michel Faure

IPC分类号： H01F27/30 ,  H01F27/26 ,  H01F37/00

CPC分类号： H01F27/263

摘要： The invention relates to a device for tightening the core and the upper and lower cross pieces of a shunt inductance winding by means of a plurality of tie rods (5, 6, 7) which are preferably seven in number and which pass through the central hole of the core. A cup-shaped part (12) held by nuts (13) is fitted onto the tie rods, the outer wall of this part is threaded, a nut (14) is screwed onto this part (12) and bears against axially elastic washers (15).

摘要翻译： 本发明涉及一种用于通过多个拉杆（5,6,7）紧固芯部以及分流电感绕组的上下交叉件的装置，该多个拉杆优选地为数量为七个，并且穿过中心孔 的核心。 由螺母（13）保持的杯状部件（12）装配到拉杆上，该部件的外壁是螺纹的，螺母（14）被拧入到该部件（12）上并且承受轴向弹性垫圈 15）。

公开(公告)号：US4321072A

公开(公告)日：1982-03-23

申请号：US206830

申请日：1980-11-14

申请人： Jacques Dubos ,  Michel Faure ,  Yves Lumineau

发明人： Jacques Dubos ,  Michel Faure ,  Yves Lumineau

IPC分类号： C03C25/10 ,  C03C25/12 ,  C03C25/18 ,  G02B6/44 ,  C03C25/02 ,  G01B9/02

CPC分类号： C03C25/12 ,  C03C25/18

摘要： Highly accurate centering of an optical fiber within a primary cladding deposited by a coating device is carried out by automatic regulation during the fiber-drawing process in order to optimize the mechanical properties of the fiber. The position of the coating device is controlled in dependence on the position of the fiber with respect to an origin of coordinates (O) determined by optoelectronic means. The frusto-conical lower end of the coating die is maintained at each instant by electronic and electromechanical means at the point (O') located at this level on the straight-line segment (OR) which joins the origin to the first point of contact of the fiber with the pulley used for guiding the fiber towards a storage drum.

摘要翻译： 通过在纤维拉伸工艺期间的自动调节，通过涂覆装置沉积的初级包层内的光纤的高精度对中来进行，以优化纤维的机械性能。 涂层装置的位置根据光纤相对于由光电装置确定的坐标原点（O）的位置来控制。 涂层模具的截头圆锥形下端通过电子和机电装置在位于在原点连接到第一接触点的直线段（OR）处的该位置处的点（O'）处被保持在每一时刻 的纤维与用于将纤维引向储存鼓的滑轮。