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    FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE
    16.
    发明申请
    FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE 有权

    公开(公告)号：US20110207806A1

    公开(公告)日：2011-08-25

    申请号：US13028853

    申请日：2011-02-16

    申请人： Qi Jia

    发明人： Qi Jia

    IPC分类号： A61K31/353 ,  A61K8/49 ,  A61P17/00 ,  A61Q19/08

    CPC分类号： A61K8/97 ,  A61K8/498 ,  A61K8/67 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/11 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/484 ,  A61K36/486 ,  A61K36/53 ,  A61K36/539 ,  A61K36/54 ,  A61K36/60 ,  A61K36/906 ,  A61K36/9062 ,  A61K45/06 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08 ,  A61K2300/00

    摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

    Polycosanols from Ericerus pela wax
    18.
    发明授权
    Polycosanols from Ericerus pela wax 有权
    来自梨果的聚山梨醇蜡

    公开(公告)号：US06683116B1

    公开(公告)日：2004-01-27

    申请号：US10356676

    申请日：2003-01-31

    申请人： Qi Jia ,  Ji-Fu Zhao

    发明人： Qi Jia ,  Ji-Fu Zhao

    IPC分类号： A01N3100

    CPC分类号： A61K31/045 ,  Y10S514/925 ,  A61K2300/00

    摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

    摘要翻译： 本发明提供了一种新颖的方法，用于制备具有24至30个碳原子的伯脂肪醇，其特征在于由昆虫螨属分泌的蜡。 本发明中包括由本发明的方法生产的物质组合物，这里称为“多可醇”。 多糖醇组合物主要由四种脂族醇，二十四烷醇，二十四烷醇，三十烷醇组成。 本发明还包括所述物质组合物用于预防和治疗肥胖症，综合征X，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。