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公开(公告)号：US11426697B2
公开(公告)日：2022-08-30
申请号：US17014485
申请日：2020-09-08
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
IPC: B01D63/02 , B01D69/08 , B01D37/04 , B01D35/26 , B01D29/11 , B01D29/90 , F04B43/00 , F04B43/06 , F04B53/20 , C12M1/00 , C12M1/12 , F04B43/067
Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.
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公开(公告)号：US10799816B2
公开(公告)日：2020-10-13
申请号：US15856210
申请日：2017-12-28
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
IPC: B01D29/90 , B01D35/26 , B01D29/11 , F04B43/02 , B01D63/02 , C12M1/00 , B01D69/08 , B01D37/04 , C12M1/12 , F04B43/00 , F04B43/067 , F04B53/20
Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion a the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.
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公开(公告)号：US20190240622A1
公开(公告)日：2019-08-08
申请号：US16263466
申请日：2019-01-31
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
Abstract: A single-use fluid storage and filtration system includes a process vessel, a filter module including a hollow fiber filter element, and a drive module coupled to the filter module. The filter module is fixed to the process vessel and is in fluid communication with the process vessel for filtering a fluid received from the process vessel. The drive module includes a pump to induce flow of the fluid between the filter module and the process vessel. The process vessel, filter module and drive module comprise a single integrated and sterilized assembly.
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公开(公告)号：US20190201820A1
公开(公告)日：2019-07-04
申请号：US15856210
申请日：2017-12-28
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
CPC classification number: B01D29/908 , B01D29/11 , B01D35/26 , B01D37/04 , B01D63/02 , B01D69/08 , B01D2313/243 , B01D2313/58 , B01D2313/90 , C12M25/02 , C12M29/10 , F04B43/0063 , F04B43/0081 , F04B43/067 , F04B53/20
Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion a the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.
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公开(公告)号：US20190040859A1
公开(公告)日：2019-02-07
申请号：US15892214
申请日：2018-02-08
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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Patent Agency Ranking
公开(公告)号：US10166497B1
公开(公告)日：2019-01-01
申请号：US15882385
申请日：2018-01-29
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.
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公开(公告)号：US20240335776A1
公开(公告)日：2024-10-10
申请号：US18748880
申请日：2024-06-20
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik , Ralf Kuriyel
CPC classification number: B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
Abstract: A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US11673083B2
公开(公告)日：2023-06-13
申请号：US17721846
申请日：2022-04-15
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik , Ralf Kuriyel
CPC classification number: B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
Abstract: A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US11578302B2
公开(公告)日：2023-02-14
申请号：US17752231
申请日：2022-05-24
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: F04B49/20 , F04B43/00 , B01D61/22 , B01D61/58 , B01D63/02 , B01D61/20 , F04B23/02 , C12M1/36 , C12M1/34 , F04B23/04 , C12M1/00 , F04B43/073 , F04B49/06
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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公开(公告)号：US11578301B2
公开(公告)日：2023-02-14
申请号：US16908225
申请日：2020-06-22
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: B01D61/22 , F04B49/20 , F04B23/04 , F04B43/00 , B01D61/58 , B01D63/02 , B01D61/20 , C12M1/36 , C12M1/34 , C12M1/00 , F04B43/073 , F04B49/06 , F04B23/02
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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