-
公开(公告)号：US20120046317A1
公开(公告)日：2012-02-23
申请号：US13318740
申请日：2010-05-06
Applicant: Chaitanya Dutt , Vijay Chauthaiwale , Ramesh Chandra Gupta , Manish Patel , Jignesh Kotecha , Sachin Latad , Jaya Abraham , Sanjay Srivastava , Milin Rode , Shailesh Deshpande , Anita Chaudhary , Amit Kumar Kesarwani
Inventor： Chaitanya Dutt , Vijay Chauthaiwale , Ramesh Chandra Gupta , Manish Patel , Jignesh Kotecha , Sachin Latad , Jaya Abraham , Sanjay Srivastava , Milin Rode , Shailesh Deshpande , Anita Chaudhary , Amit Kumar Kesarwani
IPC: A61K31/4535 , C07D213/54 , C07D211/34 , C07D409/02 , A61K31/4436 , A61K31/444 , A61K31/4439 , A61K31/435 , A61K31/445 , A61P25/00 , A61P9/12 , A61P9/04 , A61P27/02 , A61P9/10 , A61P25/28 , A61P13/12 , A61P17/00 , C07D409/14
CPC classification number: C07D409/06 , C07D211/56 , C07D211/60 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04
Abstract: The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.
Abstract translation: 本发明涉及一类新的杂环化合物及其药学上可接受的盐，其制备方法，含有这些化合物的药物组合物及其用于治疗由于AGEs的形成和积累引起的疾病（高级糖化终产物） 。 本发明的化合物可用于治疗由AGEs的形成和积累引起的糖尿病和老化相关并发症，例如神经病，肾病，微血管病变，视网膜病变，高血压，心力衰竭，动脉粥样硬化，阿尔茨海默病和皮肤病。
-
公开(公告)号：US20110130414A1
公开(公告)日：2011-06-02
申请号：US12877704
申请日：2010-09-08
Applicant: Sanjay Srivastava , Laxmikant Chhipa , Ramesh Chandra Gupta , Shailesh Deshpande , Anita Chaudhari , Anookh Mohanan , Chaitanya Dutt , Vijay Chauthaiwale , Murali Badanthadka , Prashant G. Jamadarkhana
Inventor： Sanjay Srivastava , Laxmikant Chhipa , Ramesh Chandra Gupta , Shailesh Deshpande , Anita Chaudhari , Anookh Mohanan , Chaitanya Dutt , Vijay Chauthaiwale , Murali Badanthadka , Prashant G. Jamadarkhana
IPC: A61K31/519 , C07D487/04 , C07D471/14 , A61P9/00 , A61P13/12 , A61P31/00 , A61P35/00 , A61P7/06
CPC classification number: C07D513/04 , C07D513/14
Abstract: The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.
Abstract translation: 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。
-
公开(公告)号：US09880081B1
公开(公告)日：2018-01-30
申请号：US15452267
申请日：2017-03-07
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
CPC classification number: G01N3/08 , G01N3/066 , G01N3/24 , G01N33/24 , G01N2203/0232 , G01N2203/0266 , G01N2203/0284
Abstract: The expandable jacket consists of the rubber membrane surrounding the cylindrical specimen, circular segmental metal plates surrounding the rubber membrane, and elastomeric rubber bands or rings around the segmental plates to permit uniform radial expansion and maintain uniform diameter of the specimen during the test and thereby providing accurate values of deviator stress, volume change characteristics and shear strength of soil specimen. To determine the three-dimensional coefficient of consolidation and coefficient of consolidation in horizontal direction, the flexible ring consists of all above structural components of expandable jacket except that a filter fabric or paper is wrapped around the cylindrical specimen, and then rubber membrane is mounted surrounding the filter paper or paper. The calibration device for calibration of the expandable jacket and flexible ring shall provide the magnitude of correction to be made in deviator stress and lateral resistance provided by the rubber bands or rings during the test.
-
14.发明授权Test device for determining three-dimensional consolidation properties of soils 有权用于确定土壤三维固结特性的试验装置公开(公告)号：US09546940B2
公开(公告)日：2017-01-17
申请号：US15170661
申请日：2016-06-01
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: A test device has been invented for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of the excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in the horizontal and vertical directions, and the modulus of elasticity. The flexible ring consists of a filter fabric around the soil specimen, a rubber membrane around the filter, circular shaped segmented metal plates around the membrane and rubber bands or rings around the plates. Both the incremental loading or triaxial type loading systems can be used with this device. A calibration device for calibration of the flexible ring is used to determine the modulus of elasticity of elastic elements, required for calculating lateral resistance provided by the flexible ring during the test.
Abstract translation: 已经发明了一种用于确定土壤的三维固结性质的测试装置，其使用允许水平和垂直方向上的多余孔隙的位移和消散的柔性环，并且确定水平和垂直方向上的固结系数， 和弹性模量。 柔性环由围绕土壤样品的过滤织物，过滤器周围的橡胶膜，围绕膜的圆形分段金属板和围绕板的橡胶带或环组成。 增量装载或三轴式装载系统均可与本装置一起使用。 用于校准柔性环的校准装置用于确定弹性元件的弹性模量，用于在测试期间计算柔性环提供的横向阻力所需的弹性模量。
-
15.发明申请Test Device For Determining Three-Dimensional Consolidation Properties Of Soils 审中-公开用于确定土壤三维固结性能的试验装置公开(公告)号：US20160356685A1
公开(公告)日：2016-12-08
申请号：US15170661
申请日：2016-06-01
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: Standard test methods using a fixed ring for determining one-dimensional consolidation properties of soils represent a subsurface condition where settlement and dissipation of excess pore pressure is possible only in vertical direction. This subsurface condition never occurs, as settlements and dissipation of excess pore pressures always occur in horizontal and vertical directions. Dr. Ramesh Gupta has invented a test device for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in horizontal and vertical directions including three-dimensional coefficient of consolidation, and modulus of elasticity. The test device consists of a flexible ring consisting of filter fabric around the soil specimen, rubber membrane around the filter, circular segmented metal plates around the membrane and rubber bands or rings around the plates. Both incremental or triaxial type loading can be used with this device.
Abstract translation: 使用固定环确定土壤一维固结特性的标准试验方法代表了一种地下条件，其中只能在垂直方向上沉积和消耗超孔隙压力。 这种地下条件不会发生，因为过多的孔隙压力的沉降和耗散总是在水平和垂直方向上发生。 Ramesh Gupta博士发明了一种用于确定土壤三维固结特性的测试装置，使用柔性环，允许在水平和垂直方向上移动和消散过多的孔隙压力，并提供水平和垂直方向上的固结系数的确定 包括三维固结系数和弹性模量。 测试装置由柔性环组成，围绕土壤样品的过滤织物，过滤器周围的橡胶膜，围绕膜的圆形分段金属板和围绕板的橡胶带或环。 增量式或三轴式加载均可与本装置一起使用。
-
Patent Agency Ranking
16.发明授权公开(公告)号：US09383346B2
公开(公告)日：2016-07-05
申请号：US14660887
申请日：2015-03-17
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: During triaxial compression test, a soil specimen experiences reduction of its height with increase in its diameter. New cross-sectional area is calculated assuming uniform increase in diameter. This condition is seldom met in actual soil specimens, because specimen undergoes non-uniform increase in diameter and very often with localized bulging in specimen affecting the accuracy of calculation of deviator stress, shears strength and volume change characteristics. The expandable jacket included in this invention consists of circular segmental metal plates wrapped around the soil specimen and elastomeric rubber bands or rings around the segmental plates to permit uniform radial expansion and maintain uniform diameter of the specimen during the test and thereby providing accurate values of deviator stress, volume change characteristics and shear strength of soil specimen. The calibration device for calibration of expandable jacket shall provide the magnitude of correction to be made in deviator stress.
Abstract translation: 在三轴压缩试验中，土体试样的直径随着其高度的减小而增加。 假设直径均匀增加，计算新的横截面面积。 这种情况在实际的土壤样品中很少遇到，因为样品的直径不均匀增加，常常伴随着样品中的局部隆起影响偏应力，剪切强度和体积变化特性的计算精度。 包括在本发明中的可膨胀护套由围绕土壤试样的环形节段金属板和围绕节段板的弹性橡胶带或环组成，以允许均匀的径向膨胀并且在测试期间保持试样的均匀直径，从而提供偏差的准确值 土壤样品的应力，体积变化特征和剪切强度。 用于校准可扩展护套的校准装置应提供在偏应力下进行校正的大小。
-
17.发明申请公开(公告)号：US20150268217A1
公开(公告)日：2015-09-24
申请号：US14660887
申请日：2015-03-17
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: During triaxial compression test, a soil specimen experiences reduction of its height with simultaneous increase in its diameter. For calculation of new cross-sectional area, it is always assumed that the specimen deforms as a cylinder with uniform increase in diameter through its height. This condition is seldom or never met in actual soil specimens, because specimen undergoes non-uniform increase in diameter through its height and very often with localized bulging in specimen affecting the accuracy of calculation of magnitude of deviator stress at any instant of time during the test. Non-uniform increase in diameter through its height with often localized bulging affects the real strength and volume change characteristics, and how much this effect of non-uniform lateral increase in diameter changes these properties remains unknown. The expandable jacket wrapped around the soil specimen for performing the triaxial compression test included in this invention, shall maintain uniform diameter of soil specimen through its height and shall provide accurate prediction of deviator stress, volume change characteristics and strength of soil specimen. The calibration device for calibration of expandable jacket shall provide the magnitude of correction to be made in deviator stress at various levels of axial and lateral strains.
Abstract translation: 在三轴压缩试验过程中，土壤样品的直径也随之增加，体积减小。 为了计算新的横截面积，总是假设试样通过其高度以直径均匀增加的方式变形为圆柱体。 在实际的土壤样本中，这种条件很少或从未遇到过，因为样品在直径上经历了不均匀的高度增加，并且常常伴随着样本中的局部隆起影响了测试期间任何时刻的偏差应力大小的计算精度 。 通过其高度不均匀地增加直径，经常局部隆起会影响实际强度和体积变化特征，以及直径不均匀横向增加对这些性质的影响有多少仍然未知。 用于进行本发明包括的三轴压缩试验的可扩展护套，应保持土壤样品的高度均匀的直径，并准确预测土体试样的偏应力，体积变化特征和强度。 用于校准可扩展护套的校准装置应提供在不同程度的轴向和横向应变下在偏差应力中进行校正的大小。
-
公开(公告)号：US11124937B1
公开(公告)日：2021-09-21
申请号：US17075244
申请日：2020-10-20
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.
-
公开(公告)号：US10823880B1
公开(公告)日：2020-11-03
申请号：US16814637
申请日：2020-03-10
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: Subsurface exploration using In-Situ tests such as SPT, CPT, CPTu, DMT, and PMT predicts inaccurately engineering properties of soils and intermediate geomaterials and thereby predicts incorrect load-settlement relationship of piles; variations or errors in engineering properties predicted by one empirical correlation to another correlation could be up to 50% or greater. For soft to very soft soils, engineering properties cannot be predicted as the SPT only provides information such as WOR and WOH. To overcome this problem, the invention of the application consists of performing subsurface exploration using load tests on short model piles with or without instrumentation at various depths of a soil deposit for determining accurately the above-mentioned properties. For very soft soils, a hung balance is used to hang drill rods and short model pile from a drill rig boom or from a platform with soil anchors to prevent its overturning, and then perform the load test.
-
公开(公告)号：US20150267370A1
公开(公告)日：2015-09-24
申请号：US14729157
申请日：2015-06-03
Applicant: Ramesh Chandra Gupta
Inventor： Ramesh Chandra Gupta
Abstract: Standard test methods for determining one-dimensional consolidation properties of soils using incremental loading in accordance with ASTM D2435, or AASHTO 216, and of those of other international and organizations, do not accurately predict the values of vertical settlement, coefficients of consolidation in horizontal and vertical directions, and modulus of elasticity in vertical direction, because fixed ring used in these tests do not allow horizontal settlement and dissipation of excess pore-water pressures in horizontal direction, whereas, in field, under application of a vertical load, both horizontal and vertical settlements occur along with dissipation of excess pore-water pressures in both vertical and horizontal directions. To overcome this more than 100 year old problem, the inventor (Dr. Ramesh Chandra Gupta, Ph. D., P.E.) has invented a test device for determining three-dimensional consolidation properties of soils, using a flexible ring which permits development of horizontal and vertical displacements, and dissipation of excess pore-water pressures in both horizontal and vertical directions, along with increased lateral resistance as takes place in field at any depth in a soil deposit when vertical load at the surface is applied.The flexible ring consists of filter fabric around the soil specimen, rubber membrane around the filter fabric, circular segmental metal plates around the membrane and elastomeric rubber bands or spring loaded jacket around the segmental plates, and allows horizontal and vertical displacements, dissipation of pore-water pressures in horizontal and vertical directions to take place with increased lateral resistance with each increment of vertical load like those in the field. Thus new test device simulates field condition to allow accurate determination of three-dimensional consolidation properties of soils (such as settlements, coefficients of consolidation in horizontal and vertical directions, and modulus of elasticity).For this new test device, conventional incremental consolidation frame or triaxial type chamber system either with the triaxial loading system or modified to adapt to incremental consolidation frame, shall be used to perform three-dimensional consolidation tests.
-
-
-
-
-
-
-
-
-
Search Results
22
records
(took 0.019 seconds)
