公开(公告)号：US09567722B2

公开(公告)日：2017-02-14

申请号：US14729157

申请日：2015-06-03

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D1/02 ,  G01N33/24 ,  G01N3/08

CPC classification number: E02D1/025 ,  E02D1/027 ,  G01N3/08 ,  G01N33/24

Abstract: A test device has been invented for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of the excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in the horizontal and vertical directions, and the modulus of elasticity. The flexible ring consists of a filter fabric around the soil specimen, a rubber membrane around the filter, circular shaped segmented stainless steel plates around the membrane and rubber bands around the plates. Both the incremental loading or triaxial type loading systems can be used with this device. A calibration device for calibration of the flexible ring is used to determine the modulus of elasticity of elastic elements, required for calculating lateral resistance provided by the flexible ring during the test.

Abstract translation: 已经发明了一种用于确定土壤的三维固结性质的测试装置，其使用允许水平和垂直方向上的多余孔隙的位移和消散的柔性环，并且确定水平和垂直方向上的固结系数， 和弹性模量。 柔性环由围绕土壤样品的过滤织物，过滤器周围的橡胶膜，围绕膜的圆形分段不锈钢板和围绕板的橡胶带组成。 增量装载或三轴式装载系统均可与本装置一起使用。 用于校准柔性环的校准装置用于确定弹性元件的弹性模量，用于在测试期间计算柔性环提供的横向阻力所需的弹性模量。

公开(公告)号：US08541430B2

公开(公告)日：2013-09-24

申请号：US12877704

申请日：2010-09-08

Applicant: Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

Inventor： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC: A01N43/54 ,  A61K31/505

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Abstract translation: 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US11566985B1

公开(公告)日：2023-01-31

申请号：US17714368

申请日：2022-04-06

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: G01N3/10 ,  G01N33/24 ,  G01N3/08

Abstract: Expandable Jacket surrounding a pressuremeter probe prevents barrel shape to form and maintains cylindrical shape with uniform radial displacement throughout its height, removing shortcomings of the existing pressuremeters. For the pressuremeter probe to determine horizontal stress versus plane strain relationship in soils and intermediate geomaterials, an expandable comprises of one layer of circular arch shaped segmented plates surrounded by flexible bands or rings. The expandable jacket surrounds a membrane which itself surrounds a porous tube with holes. Borehole less than the diameter of probe is drilled either by pre-boring or self-boring and then pushing the probe with cutter ring. For the pressuremeter probe to determine horizontal stress versus plane lateral strain relationship for rocks, the expandable jacket comprises of two layers of the circular arch shaped segmented plates surrounded by flexible bands or rings and first layer surrounding a plurality of pistons, and second layer surrounding the first layer.

公开(公告)号：US10060898B2

公开(公告)日：2018-08-28

申请号：US15838660

申请日：2017-12-12

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: G01N19/06 ,  G01N33/24 ,  E02D1/02 ,  G01N3/08

CPC classification number: G01N33/24 ,  E02D1/025 ,  E02D1/027 ,  G01N3/08 ,  G01N3/12 ,  G01N2203/0254 ,  G01N2203/0266

Abstract: The expandable jacket and flexible ring comprises of the segmented circular arch shaped plates and bands or rings around the segmented plates. The test preparation consists of a membrane surrounding a specimen with or without a filter, segmented plates surrounding the membrane, and bands or rings around the segmented plates to permit uniform radial expansion of the specimen through its height when increments of vertical load are applied during the test, thereby providing accurate values of area of cross-section, deviator stress, volume change, modulus of elasticity, Poisson's ratio and shear strength. Using the flexible ring, three-dimensional consolidation tests are performed to determine three-dimensional coefficient of consolidation and coefficients of consolidation in horizontal and vertical directions. Removable attachments are used for assembling the expandable jacket and flexible ring during the test. A calibration device is used to determine the modulus of elasticity of the membrane and expandable jacket and flexible ring.

公开(公告)号：US20100010035A1

公开(公告)日：2010-01-14

申请号：US12224617

申请日：2007-03-01

Applicant: Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Tim Perkins ,  Christer Westerlund

Inventor： Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Tim Perkins ,  Christer Westerlund

IPC: A61K31/422 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/4439 ,  C07D471/04 ,  C07D413/14 ,  A61P9/12

CPC classification number: C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.

Abstract translation: 本发明涉及下式的新化合物：[化学式应在此插入。 请参见纸质文件]其中R1，R2，R3和R31如本文所述。 本发明还涉及其制备方法，以及新化合物与先前已知的试剂的组合。 本发明还涉及上述化合物和组合物在制备用于治疗不同种类的高血压，减轻不同种类的器官损伤，治疗或预防糖尿病肾病，治疗内皮素和血管紧张素介导的病症以及治疗 前列腺癌。

公开(公告)号：US20090088432A1

公开(公告)日：2009-04-02

申请号：US11992016

申请日：2006-09-15

Applicant: Rakesh Kumar Banerjee ,  Ramesh Chandra Gupta ,  Davinder Tuli ,  Milind Rode ,  Bharat Suthar ,  Dhananjay Umrani ,  Padmaja Pathak ,  Tejal Choksi ,  Anita Chaudhary

Inventor： Rakesh Kumar Banerjee ,  Ramesh Chandra Gupta ,  Davinder Tuli ,  Milind Rode ,  Bharat Suthar ,  Dhananjay Umrani ,  Padmaja Pathak ,  Tejal Choksi ,  Anita Chaudhary

IPC: A61K31/5377 ,  C07D277/38 ,  C07D413/02 ,  A61K31/426

CPC classification number: C07F9/6539 ,  C07D263/48 ,  C07D277/20 ,  C07D277/42 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention encompasses; the novel substituted heterocyclic compounds represented by formula (I) or their pharmaceutically acceptable salts, wherein the substituents in formula (I) have the meanings as defined in the specification. The invention also encompasses process for preparing such compound, pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.

Abstract translation: 本发明包括 由式（I）表示的新型取代的杂环化合物或其药学上可接受的盐，其中式（I）中的取代基具有如说明书中所定义的含义。 本发明还包括制备这种化合物的方法，药物组合物和治疗或预防PTP-1B介导的疾病的方法。

公开(公告)号：US11486110B2

公开(公告)日：2022-11-01

申请号：US17556364

申请日：2021-12-20

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/24 ,  E02D3/12 ,  E02D3/08 ,  E02D7/02

Abstract: The porous displacement piles comprising (a) closed-ended pipe piles with small holes and or narrow slots, filled with compacted sandy soil, (b) closed-ended porous pipe piles such as closed-ended pipe pile with very small holes and or very narrow slots, and (c) a precast prestressed porous concrete piles are driven through inside the already driven non-displacement hollow pipe piles in a grid pattern to create excess pore-water pressures generally ranging between 50 and 1500 kPa in cohesive soils, which begin dissipating through inside the porous displacement piles to rapidly consolidate and densify the said cohesive soil. The porous displacement piles are designed for permitting free flow of the pressurized pore-water and to prevent migration of particles of cohesive soil into the porous displacement pile using filter design criteria or verified by laboratory tests. These piles when driven in sandy soils densify sandy soils instantaneously.

公开(公告)号：US20220235531A1

公开(公告)日：2022-07-28

申请号：US17637751

申请日：2020-11-20

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/66 ,  E02D7/06 ,  E02D27/16 ,  E02D27/34

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

公开(公告)号：US11261576B1

公开(公告)日：2022-03-01

申请号：US17090858

申请日：2020-11-05

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/24 ,  E02D27/16 ,  E02D7/02

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

公开(公告)号：US20180120283A1

公开(公告)日：2018-05-03

申请号：US15838660

申请日：2017-12-12

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: G01N33/24 ,  G01N3/08 ,  E02D1/02

CPC classification number: G01N33/24 ,  E02D1/025 ,  E02D1/027 ,  G01N3/08 ,  G01N3/12 ,  G01N2203/0254 ,  G01N2203/0266

Abstract: The expandable jacket and flexible ring comprises of the segmented circular arch shaped plates and bands or rings around the segmented plates. The test preparation consists of a membrane surrounding a specimen with or without a filter, segmented plates surrounding the membrane, and bands or rings around the segmented plates to permit uniform radial expansion of the specimen through its height when increments of vertical load are applied during the test, thereby providing accurate values of area of cross-section, deviator stress, volume change, modulus of elasticity, Poisson's ratio and shear strength. Using the flexible ring, three-dimensional consolidation tests are performed to determine three-dimensional coefficient of consolidation and coefficients of consolidation in horizontal and vertical directions. Removable attachments are used for assembling the expandable jacket and flexible ring during the test. A calibration device is used to determine the modulus of elasticity of the membrane and expandable jacket and flexible ring.