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124 条记录 (耗时 0.091 秒)

    Polynucleotides encoding human tumor necrosis factor receptor-like2
    11.
    发明授权
    Polynucleotides encoding human tumor necrosis factor receptor-like2 失效
    编码人肿瘤坏死因子受体的多核苷酸2

    公开(公告)号：US07427492B1

    公开(公告)日：2008-09-23

    申请号：US08741095

    申请日：1996-10-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/64 ,  C12N15/09 ,  C12N5/16 ,  C12N5/10 ,  C12N1/11 ,  C12N1/15 ,  C12N1/21

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    Death domain containing receptor-4 antibodies
    13.
    发明授权
    Death domain containing receptor-4 antibodies 有权
    含有受体-4抗体的死亡域

    公开(公告)号：US06461823B1

    公开(公告)日：2002-10-08

    申请号：US09448868

    申请日：1999-11-24

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： G01N33567

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。

    Death domain containing receptor-4
    14.
    发明授权
    Death domain containing receptor-4 有权
    死亡域含受体4

    公开(公告)号：US06433147B1

    公开(公告)日：2002-08-13

    申请号：US09565918

    申请日：2000-05-05

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： C07K14705

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K39/39541 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/30 ,  C12N2799/026 ,  A61K2300/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。

    Death domain containing receptor 4 antibodies and methods
    15.
    发明授权
    Death domain containing receptor 4 antibodies and methods 有权
    含有受体4抗体的死亡域和方法

    公开(公告)号：US08329179B2

    公开(公告)日：2012-12-11

    申请号：US12010108

    申请日：2008-01-18

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  A61K31/00 ,  C07K16/30

    CPC分类号： C07K14/70578 ,  A01K2267/035 ,  C07K16/2878 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    Methods of determining the level of human tumor necrosis factor receptor-like 2
    16.
    发明授权
    Methods of determining the level of human tumor necrosis factor receptor-like 2 失效
    确定人肿瘤坏死因子受体样水平的方法2

    公开(公告)号：US07910321B2

    公开(公告)日：2011-03-22

    申请号：US12235837

    申请日：2008-09-23

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

    IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/563 ,  G01N33/577

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    Death domain containing receptor 4 antibody and methods
    17.
    发明授权
    Death domain containing receptor 4 antibody and methods 有权
    含有受体4抗体的死亡域和方法

    公开(公告)号：US07476384B2

    公开(公告)日：2009-01-13

    申请号：US11076187

    申请日：2005-03-10

    申请人： Jian Ni ,  Craig A. Rosen ,  James Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  A61K38/21 ,  C07K14/56 ,  C07K14/705

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    Death domain containing receptor 4
    18.
    发明申请
    Death domain containing receptor 4 有权
    死亡域含受体4

    公开(公告)号：US20080241155A1

    公开(公告)日：2008-10-02

    申请号：US12010108

    申请日：2008-01-18

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07K14/70578 ,  A01K2267/035 ,  C07K16/2878 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    Death domain containing receptor 5
    20.
    发明授权
    Death domain containing receptor 5 有权
    含有受体5的死亡域

    公开(公告)号：US06743625B2

    公开(公告)日：2004-06-01

    申请号：US09874138

    申请日：2001-06-06

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： C07K14705

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  A61K39/395 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30 ,  A61K2300/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。