公开(公告)号：US5859434A

公开(公告)日：1999-01-12

申请号：US897228

申请日：1997-07-21

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01N21/55 ,  G01N21/35

CPC classification number: G01N21/552

Abstract: A system for delivering infrared energy to a sample using frustrated internal reflectance in which a crystal for receiving the infrared energy is formed integrally with a removable mounting card. The mounting card is removable so that new samples can be sampled by quickly replacing the crystal with a new crystal having a new sample for analysis. Preferably, the crystal has the shape of a Fresnel lens. The infrared energy can be delivered to the crystal so that it experiences a single internal reflection and mounted in a card to form a surface that is integral with one side of the card to facilitate rapid cleaning and reuse of the card.

Abstract translation: 使用沮丧的内反射将红外能量传递到样品的系统，其中用于接收红外能的晶体与可移除的安装卡一体地形成。 安装卡是可移动的，以便通过用新的样品快速更换晶体来采样新样品，以便进行分析。 优选地，晶体具有菲涅尔透镜的形状。 红外能量可以传送到晶体，使得其经历单个内部反射并且安装在卡中以形成与卡的一侧成一体的表面，以便于卡的快速清洁和再利用。

公开(公告)号：US5225678A

公开(公告)日：1993-07-06

申请号：US792195

申请日：1991-11-13

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01J3/453 ,  G01N21/25 ,  G01N21/35 ,  G01N21/55 ,  G01N21/65 ,  G02B21/04

CPC classification number: G02B21/04 ,  G01N21/255 ,  G01J3/453 ,  G01N2021/1738 ,  G01N2021/558 ,  G01N21/35

Abstract: A microscope accessory uses symmetrical pairs of identical parabolic mirrors as an imaging optic to map a specimen plane with a remote focus. A mask at the remote focus defines at least one measuring area for making spectroscopic measurements while a separate viewing system simultaneously provides a wide field of view of the sample at higher magnification. The sample aperture, defines as 2T sterradians of solid angle surrounding each side of the specimen plane, is multiplexed between and among different functions--such as spectroscopic measurements and visual observations. The high numerical aperture possible using identical symmetrical aberration canceling (ISAC) optics facilitates the aperture multiplexing which has particular advantage in making reflectance measurements without any need for a significant loss of throughput efficiency.

Abstract translation: 显微镜附件使用对称的相同的抛物面反射镜作为成像光学元件来将样品平面与远焦点对准。 在远程焦点处的掩模限定了用于进行光谱测量的至少一个测量区域，而单独的观察系统同时在较高放大倍数下提供样品的宽视场。 样品孔径定义为围绕样品平面两边的立体角的2T立体角，在不同的功能之间进行复用，例如光谱测量和视觉观察。 使用相同的对称像差消除（ISAC）光学可能的高数值孔径有助于孔径复用，这在进行反射测量时具有特别的优点，而不需要显着的吞吐效率损失。

公开(公告)号：US20120274934A1

公开(公告)日：2012-11-01

申请号：US13098140

申请日：2011-04-29

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01J3/44 ,  G01J5/00

CPC classification number: G01N21/65 ,  G01N2021/4704

Abstract: Described are systems and methods for variable angle Raman spectroscopy, in which electromagnetic radiation will be caused to intersect the sample under investigation at a plurality of angles of incidence, so as to provide Raman scattering spectra at each angle. One example use of measuring such spectra at multiple angles of incidence is to enable evaluation at a plurality of depths within the sample. In many implementations, the range of the angles of incidence will include, and extend to either side, of the critical angle.

Abstract translation: 描述了用于可变角拉曼光谱的系统和方法，其中将使电磁辐射以多个入射角与待研究的样品相交，以便在每个角度提供拉曼散射光谱。 以多个入射角度测量这种光谱的一个例子是使得能够在样品内的多个深度进行评估。 在许多实施方案中，入射角的范围将包括并延伸到临界角的任一侧。

公开(公告)号：US5828066A

公开(公告)日：1998-10-27

申请号：US674869

申请日：1996-07-02

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01J3/10 ,  G01J3/12 ,  G01J3/18 ,  G01J3/28 ,  G01J3/45 ,  G01N21/35

CPC classification number: G01J3/10 ,  G01J3/12 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/45 ,  G01J3/021 ,  G01J3/0229

Abstract: A spectrometer having a source of broad band infrared energy, a relay mirror that focuses the infrared energy at an intercepting mirror, a first object mirror that collimates the infrared energy from the intercepting mirror, a spatial light modulator that receives the collimated infrared energy and reflects it back to the first object mirror, the spatial light modulator including deformable mirror elements, and a controller that deforms the mirror elements according to a predetermined pattern. Deformable mirror elements obtain needed spectra while reducing the mechanical complexity of the spectrometer.

公开(公告)号：US5636633A

公开(公告)日：1997-06-10

申请号：US513094

申请日：1995-08-09

Applicant: Robert G. Messerschmidt ,  Mark R. Robinson

Inventor： Robert G. Messerschmidt ,  Mark R. Robinson

IPC: G01N21/35 ,  G01N21/47 ,  G01N21/49 ,  A61B5/00

CPC classification number: G01N21/474 ,  G01N21/4738 ,  G01N21/49

Abstract: An improved apparatus for diffuse reflectance spectroscopy having a specular control device. The specular control device has at least a first surface divided into an even-numbered plurality of reflecting sections and open or transmitting sections. The number of reflecting sections is equal to the number of open sections. Each reflecting section is situated between a pair of open sections and opposite to another reflecting section. Similarly, each open section is situated between a pair of reflecting sections and is opposite to another open section. In one preferred embodiment, the total surface area of the reflecting sections is equal to the total surface area of the open sections. In another embodiment, the total surface area of the reflecting sections is unequal to the total surface area of the open sections. In another preferred embodiment, opaque spacers are provided on the borders between adjacent sections to improve the detecting definition between source and reflected beams, and, to selectively provide for decreasing surface area of one or more selected sections.

Abstract translation: 一种用于具有镜面控制装置的改进的用于漫反射光谱的装置。 镜面控制装置至少具有分成偶数个多个反射部分和打开或发射部分的第一表面。 反射部分的数量等于开放部分的数量。 每个反射部分位于一对开口部分之间并且与另一个反射部分相对。 类似地，每个开口部分位于一对反射部分之间并且与另一个开口部分相对。 在一个优选实施例中，反射部分的总表面面积等于开口部分的总表面积。 在另一个实施例中，反射部分的总表面积不等于开口部分的总表面积。 在另一优选实施例中，在相邻部分之间的边界上提供不透明的间隔物，以改进源和反射光束之间的检测定义，并且选择性地提供一个或多个所选部分的减小的表面积。

公开(公告)号：US5051602A

公开(公告)日：1991-09-24

申请号：US627730

申请日：1990-12-14

Applicant: Donald W. Sting ,  Robert G. Messerschmidt ,  John A. Reffner

Inventor： Donald W. Sting ,  Robert G. Messerschmidt ,  John A. Reffner

IPC: G01N21/47 ,  G01N21/55

CPC classification number: G01N21/4738 ,  G01N21/55

Abstract: An optical system, apparatus and method for analyzing samples includes a radiant energy source, a first mask, a first mirror system, a sample plane, a second mirror system, a second mask and a detector. The first and second masks are respectively positioned along the optical path of the system in the same or different Fourier planes and/or conjugate planes thereof. The first mask has at least one inlet aperture with the relative position thereof in the first mask determining the angle of the energy incidence onto the sample. The second mask has at least one outlet aperture therein passing radiant energy therethrough which has been reflected from or transmitted through the sample at a preselected angle determined by the relative position of the second aperture in the second mask. Numerous first and second masks respectively having inlet and outlet apertures at different radial and/or circumferential positions may be used in the optical system to perform many types of analyses without moving or specially preparing the sample.

公开(公告)号：US4877960A

公开(公告)日：1989-10-31

申请号：US293549

申请日：1989-01-04

Applicant: Robert G. Messerschmidt ,  Donald W. Sting

Inventor： Robert G. Messerschmidt ,  Donald W. Sting

IPC: G01N21/35 ,  G02B21/00

CPC classification number: G01N21/35 ,  G02B21/0004 ,  G01N2021/1742 ,  G01N2021/3595

Abstract: A universal microscope for use with a commercial FT-IR spectrophotometer comprises a visible light microscope for selecting and masking an area of a sample and an infrared microscope for sampling the masked area. The visible light microscope and the infrared microscope share a common optical path between one or more remote sample image plane masks and the sample plane such that both the visible light and the infrared radiant energy are masked twice to spatially define the same area at the sample plane. The first sample image plane mask removes energy from outside the target area at the sample focus. The second sample image plane mask removes energy from outside the target area that is diffracted by the first mask or the focusing optics. The first remote sample image plane is imaged onto the second remote image plane with the radiant energy gaining spectroscopic information and additional image information by passing through or reflecting off a sample located at the intervening sample plane. Samples having a diameter of less than 8 microns have been spectroscopically isolated with 2-25 micron infrared radiant energy.

Abstract translation: 用于商业FT-IR分光光度计的通用显微镜包括用于选择和掩蔽样品区域的可见光显微镜和用于对掩蔽区域进行取样的红外显微镜。 可见光显微镜和红外显微镜共享一个或多个远程样本图像平面掩模和样本平面之间的共同光路，使得可见光和红外辐射能两者被掩蔽两次，以在样本平面上空间定义相同的面积 。 第一个样本图像平面掩模在样品焦点处从目标区域外部去除能量。 第二样本图像平面掩模从由第一掩模或聚焦光学器件衍射的目标区域外部去除能量。 将第一远程采样图像平面成像到第二远程图像平面上，其辐射能通过穿过或反射位于中间样本平面处的样本获得光谱信息和附加图像信息。 具有小于8微米直径的样品已经用2-25微米的红外辐射能进行光谱分离。

公开(公告)号：US20140051941A1

公开(公告)日：2014-02-20

申请号：US13588902

申请日：2012-08-17

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: A61B5/0205 ,  A61B5/1455 ,  A61B5/024 ,  A61B5/01 ,  A61B5/053 ,  A61B5/0404 ,  A61B5/103 ,  A61B5/00 ,  A61B5/04

CPC classification number: A61B5/02125 ,  A61B5/02055 ,  A61B5/02416 ,  A61B5/02438 ,  A61B5/0404 ,  A61B5/0533 ,  A61B5/0537 ,  A61B5/6898

Abstract: An apparatus and method for obtaining one or more physiological measurements associated with a user using a portable device alone or in combination with a detachable unit is disclosed herein. One or more of different types of sensor sets are included in one or more planar surfaces of the portable device and/or the detachable unit in communication with the portable device. The accuracy of physiological measurements is automatically ensured by the fixed positioning of the sensors relative to each other. A variety of different physiological measurements can be obtained using a portable device that users normally carry around and use on a daily basis, instead of requiring use of a separate/dedicated medical device.

Abstract translation: 本文公开了一种用于使用单独的或与可拆卸单元组合的便携式设备来获得与用户相关联的一个或多个生理测量的装置和方法。 一种或多种不同类型的传感器组包括在与便携式设备通信的便携式设备和/或可拆卸单元的一个或多个平面表面中。 通过传感器相对于彼此的固定定位自动确保生理测量的准确性。 可以使用用户通常携带并且每天使用的便携式设备来获得各种不同的生理测量值，而不需要使用单独/专用的医疗设备。

公开(公告)号：US07623906B2

公开(公告)日：2009-11-24

申请号：US10292109

申请日：2002-11-12

Applicant: M. Ries Robinson ,  Robert G. Messerschmidt

Inventor： M. Ries Robinson ,  Robert G. Messerschmidt

IPC: A61B6/00

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2562/0242

Abstract: An improved method and apparatus for diffuse reflectance spectroscopy. A specular control device is provided that can discriminate between diffusely reflected light that is reflected from selected depths or layers within the tissue. The specular control device permits a spectroscopic analyzer to receive the diffusely reflected light that is reflected from, for example, a first layer or depth within the tissue, while preventing the remaining diffusely reflected light from reaching the spectroscopic analyzer. Furthermore, the specular control device may prevent the specularly reflected light (e.g. surface reflected light) from reaching the spectroscopic analyzer.

Abstract translation: 一种用于漫反射光谱的改进方法和装置。 提供了一种镜面控制装置，其可以区分从组织内的选定深度或层反射的漫反射光。 镜面控制装置允许光谱分析仪接收从例如组织内的第一层或深度反射的漫反射光，同时防止剩余的漫反射光到达光谱分析仪。 此外，镜面控制装置可以防止镜面反射光（例如表面反射光）到达光谱分析仪。

公开(公告)号：US07161679B2

公开(公告)日：2007-01-09

申请号：US10309994

申请日：2002-12-04

Applicant: Robert G. Messerschmidt ,  Russell E. Abbink

Inventor： Robert G. Messerschmidt ,  Russell E. Abbink

IPC: G01B9/02

CPC classification number: G01J3/453

Abstract: An interferometer spectrometer that has reduced alignment sensitivity is described herein. Parallelism of an output ray pair formed by a single input ray is not affected by variations in relative alignment of the components. In comparison to other compensated interferometer designs, lateral separation errors in the output ray pair due to optical component misalignment are reduced. The reduced alignment sensitivity may be accomplished by utilizing simple planar components that are common to both light paths. The reduced alignment sensitivity and simplicity in design provides a more compact and more robust interferometer, with reduced manufacturing costs associated therewith. An elliptical field of view light source that utilizes an array of collimator lenses is also described. The light source provides a more compact design than a single circular collimator lens of the same area, and is suitable for single channel or multi-channel use.

Abstract translation: 本文描述了具有降低的对准灵敏度的干涉仪光谱仪。 由单个输入光线形成的输出光线对的平行度不受组件相对对准的变化的影响。 与其他补偿干涉仪设计相比，减少了由于光学部件失准导致的输出光线对中的横向分离误差。 降低的对准灵敏度可以通过利用两个光路通用的简单平面部件来实现。 降低的对准灵敏度和设计简单性提供了更紧凑和更强大的干涉仪，同时降低了与之相关的制造成本。 还描述了利用准直透镜阵列的椭圆视场光源。 光源提供比同一区域的单个圆形准直透镜更紧凑的设计，并且适用于单通道或多通道使用。