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公开(公告)号：US20210061924A1
公开(公告)日：2021-03-04
申请号：US17069349
申请日：2020-10-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Alfred Engel , Frank Kroner , Thomas Meier , Sandra Rutz , Michael Schraeml , Gloria Tabares , Ulrike Kurtkaya , Boris Pinchuk , Christina Zimmermann
IPC: C07K16/40 , G01N33/543
Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.
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公开(公告)号：US20210009668A1
公开(公告)日：2021-01-14
申请号：US17015662
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB. 5
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公开(公告)号：US10564151B2
公开(公告)日：2020-02-18
申请号：US15146226
申请日：2016-05-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Schraeml , Markus Roessler , Michael Gerg
IPC: G01N33/543
Abstract: The present invention relates to a method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto.
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公开(公告)号：US20170096487A1
公开(公告)日：2017-04-06
申请号：US15083686
申请日：2016-03-29
Inventor： Monika Soukupova , Michael Schraeml , Birgit Bossenmaier , Patrick C. Roche , Michael Gerg , Sebastian Dziadek
IPC: C07K16/28 , G01N33/574 , C07K16/30 , G01N33/74 , G01N1/30
CPC classification number: C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
Abstract: The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.
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公开(公告)号：US20160137728A1
公开(公告)日：2016-05-19
申请号：US15003988
申请日：2016-01-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Herbert Andres , Hartmut Duefel , Michael Gerg , Frank Kowalewsky , Christian Scholz , Michael Schraeml
IPC: C07K16/22
CPC classification number: C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
Abstract: Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
Abstract translation: 分离的抗体特异性结合包含在人类胰岛素样生长因子-1前体的氨基酸76至氨基酸84的氨基酸区段中的表位（SEQ ID NO：1）。 在一些实施方案中，当存在高过量浓度的胰岛素样生长因子-2（例如在体液样品中）时，使用新型抗体用于敏感和特异性检测胰岛素样生长因子-1。
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Patent Agency Ranking
公开(公告)号：US10982007B2
公开(公告)日：2021-04-20
申请号：US15465439
申请日：2017-03-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
IPC: C07K16/46 , G01N33/531
Abstract: A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.
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公开(公告)号：US20210009993A1
公开(公告)日：2021-01-14
申请号：US17015719
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to a novel method of generating libraries of polynucleotides encoding a framework region and at least one adjacent complementarity determining region (CDR) of an antibody of interest. These libraries are suitable for use in affinity maturation procedures in order to obtain maturated antibodies with improved characteristics compared to the parent antibody.
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公开(公告)号：US20190309091A1
公开(公告)日：2019-10-10
申请号：US16450186
申请日：2019-06-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Lars Hillringhaus , Klaus Hirzel , Caroline Dorothea Hojer , Hans-Peter Josel , Christoph Seidel , Michael Schraeml , Leopold Von Proff
IPC: C07K16/44 , G01N33/543
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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公开(公告)号：US20190292535A1
公开(公告)日：2019-09-26
申请号：US16074128
申请日：2012-11-08
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： David Casagolda Vallribera , Frank Kroner , Michael Schraeml
Abstract: The present disclosure is directed to a library of chimeric polypeptides comprising one or more fragments from the peptidyl-prolyl cis/trans isomerase or FKBP family displaying one or more polypeptides on one or more FKBP members and its use in methods for the screening and selection of constrained peptide surrogates exhibiting binding activity versus predetermined target molecules.
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公开(公告)号：US10414818B2
公开(公告)日：2019-09-17
申请号：US15025230
申请日：2014-09-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Schraeml , David Casagolda Vallribera , Frank Kroner
IPC: C07K16/12 , G01N33/577
Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
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