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公开(公告)号：US20200033342A1
公开(公告)日：2020-01-30
申请号：US16577175
申请日：2019-09-20
发明人： Elke Faatz , Christian Scholz , Peter Muench
IPC分类号： G01N33/569 , C07K14/005
摘要： The invention concerns soluble and antigenic HTLV p24 variants that can be fused to chaperones and their use in diagnostic applications such as immunoassays for detecting antibodies against HTLV-I or HTLV-II in an isolated biological sample. In particular, the invention relates to a soluble HTLV-I or HTLV-II p24 antigen comprising either the N- or the C-terminal domain of p24 and lacking the other domain. Moreover, the invention covers recombinant DNA molecules encoding these HTLV-I and -II fusion antigens as well as their recombinant production using expression vectors and host cells transformed with such expression vectors. In addition, the invention focuses on compositions of these HTLV p24 antigens with HTLV gp21 antigen and on an immunoassay method for detection of HTLV antibodies using the antigens of the invention. Also the use of HTLV p24 antigens in an in vitro diagnostic assay as well as a reagent kit for detection of anti-HTLV-antibodies comprising said HTLV antigens is encompassed.
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公开(公告)号：US10094828B2
公开(公告)日：2018-10-09
申请号：US15587842
申请日：2017-05-05
IPC分类号： A61K39/00 , C07K14/44 , G01N33/569 , A61K39/005 , G01N33/564
摘要： The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi (T. cruzi) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.
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公开(公告)号：US09273144B2
公开(公告)日：2016-03-01
申请号：US14069445
申请日：2013-11-01
发明人： Herbert Andres , Hartmut Duefel , Michael Gerg , Frank Kowalewsky , Christian Scholz , Michael Schraeml
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
摘要翻译： 分离的抗体特异性结合包含在人类胰岛素样生长因子-1前体的氨基酸76至氨基酸84的氨基酸区段中的表位（SEQ ID NO：1）。 在一些实施方案中，当存在高过量浓度的胰岛素样生长因子-2（例如在体液样品中）时，使用新型抗体用于敏感和特异性检测胰岛素样生长因子-1。
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4.发明申请公开(公告)号：US20150079604A1
公开(公告)日：2015-03-19
申请号：US14335022
申请日：2014-07-18
IPC分类号： G01N33/571 , C07K14/20
CPC分类号： G01N33/571 , C07K14/20 , C07K2319/00 , G01N2333/20 , G01N2469/20
摘要： The invention concerns soluble variants of Treponema pallidum antigen 47 (TpN47 antigen) comprising at least domain B, or at least domains A and B, optionally domain D of the complete TpN47 protein molecule with the proviso that all antigens lack domain C (amino acid residues 224 to 351) of TpN47. The Tpn47 antigens can be fused to a chaperone. Moreover, the invention covers DNA encoding the antigens, a method of producing these antigens as well as the use of these antigens in an immunodiagnostic assay for the detection of antibodies against Treponema pallidum in an isolated sample.
摘要翻译： 本发明涉及包含至少结构域B或者至少结构域A和B，完全TpN47蛋白质分子的任选区域D的梅毒螺旋体抗原47（TpN47抗原）的可溶性变体，条件是所有抗原都缺乏结构域C（氨基酸残基 224〜351）TpN47。 Tpn47抗原可以融合到伴侣。 此外，本发明涵盖编码抗原的DNA，制备这些抗原的方法以及在免疫诊断测定中使用这些抗原来检测分离样品中针对梅毒螺旋体的抗体。
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公开(公告)号：US12018053B2
公开(公告)日：2024-06-25
申请号：US17705704
申请日：2022-03-28
发明人： Elke Faatz , Alexander Riedel , Christian Scholz , Peter Muench , Gloria Tabares , Mario Gloeck , Silke Luebcke , Juliane Benz
IPC分类号： C07K14/18 , C07K14/005 , C12N7/00 , G01N33/569
CPC分类号： C07K14/1825 , C07K14/005 , C12N7/00 , G01N33/56983 , C07K2319/33 , C07K2319/35 , C12N2770/24031 , C12N2770/24122 , C12N2770/24131 , C12N2770/24151 , G01N2333/185 , G01N2469/20 , G01N2800/26
摘要： The disclosure relates to a polypeptide suitable for detecting antibodies against a flavivirus in an isolated biological sample having a flavivirus NS1 wing domain specific amino acid sequence, wherein no amino acid sequences from the NS1 β-ladder domain of said flavivirus are present in the polypeptide. In an embodiment, the flavivirus is selected from Zika virus (ZIKV), West-Nile virus (WNV), Dengue virus types 1-4 (DENV1-4), tick-borne encephalitis virus (TBEV), yellow fever virus (YFV) and Japanese encephalitis virus (JEV). Also disclosed is a method for producing said flaviviral NS1 wing domain specific polypeptides, a method for detecting antibodies specific for a first flavivirus species, the use of said flaviviral NS1 wing domain specific polypeptides for detecting antibodies as well as a reagent kit for detecting said flavivirus antibodies that has a flavivirus NS1 wing domain polypeptide.
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公开(公告)号：US20230120988A1
公开(公告)日：2023-04-20
申请号：US17907039
申请日：2021-04-22
发明人： Frederik Baumkoetter , Juliane Benz , Markus Eckl , Peter Muench , Alexander Riedel , Christian Scholz
IPC分类号： G01N33/569 , C07K14/005
摘要： The present invention relates to a Corona antigen comprising a Corona nucleocapsid specific amino acid sequence, compositions, and reagent kits comprising the same and methods of producing it. Also encompassed are methods of detecting anti-Corona antibodies in samples using said Corona antigen, and methods of differential diagnosis of an immune response in a patient due to natural Corona infection or due to vaccination against Corona.
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公开(公告)号：US20220220158A1
公开(公告)日：2022-07-14
申请号：US17705704
申请日：2022-03-28
发明人： Elke Faatz , Alexander Riedel , Christian Scholz , Peter Muench , Gloria Tabares , Mario Gloeck , Silke Luebcke , Juliane Benz
IPC分类号： C07K14/18 , C12N7/00 , G01N33/569 , C07K14/005
摘要： The disclosure relates to a polypeptide suitable for detecting antibodies against a flavivirus in an isolated biological sample having a flavivirus NS1 wing domain specific amino acid sequence, wherein no amino acid sequences from the NS1 β-ladder domain of said flavivirus are present in the polypeptide. In an embodiment, the flavivirus is selected from Zika virus (ZIKV), West-Nile virus (WNV), Dengue virus types 1-4 (DENV1-4), tick-borne encephalitis virus (TBEV), yellow fever virus (YFV) and Japanese encephalitis virus (JEV). Also disclosed is a method for producing said flaviviral NS1 wing domain specific polypeptides, a method for detecting antibodies specific for a first flavivirus species, the use of said flaviviral NS1 wing domain specific polypeptides for detecting antibodies as well as a reagent kit for detecting said flavivirus antibodies that has a flavivirus NS1 wing domain polypeptide.
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公开(公告)号：US20210349090A1
公开(公告)日：2021-11-11
申请号：US16867750
申请日：2020-05-06
发明人： Alexander Riedel , Christian Scholz , Peter Muench , Juliane Benz , Markus Eckl , Frederik Baumkoetter
IPC分类号： G01N33/569 , C07K14/005
摘要： The present description relates to a Corona antigen having a Corona nucleocapsid specific amino acid sequence, compositions, and reagent kits having the same and methods of producing it. Also encompassed are methods of detecting anti-Corona antibodies in samples using the Corona antigen, and methods of differential diagnosis of an immune response in a patient due to natural Corona infection or due to vaccination against Corona.
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公开(公告)号：US10301383B2
公开(公告)日：2019-05-28
申请号：US15003988
申请日：2016-01-22
发明人： Herbert Andres , Hartmut Duefel , Michael Gerg , Frank Kowalewsky , Christian Scholz , Michael Schraemi
IPC分类号： C07K16/00 , C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
摘要： Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.
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公开(公告)号：US09714949B2
公开(公告)日：2017-07-25
申请号：US14334773
申请日：2014-07-18
IPC分类号： G01N33/53 , G01N33/68 , C07K14/28 , G01N33/571 , C07K14/245
CPC分类号： G01N33/6854 , C07K14/245 , C07K14/28 , C07K2319/35 , G01N33/5306 , G01N33/571 , G01N2333/20 , G01N2333/28 , G01N2469/20 , G01N2800/26
摘要： The invention relates to a method for detecting antibodies against the TpN17 antigen of Treponema pallidum in an isolated sample wherein a peptide sequence of Vibrio cholerae lipoprotein 15 (VcLp15) or a partial sequence thereof is used as a reagent for reduction of interference, i.e. for minimizing false positive results. In addition the invention relates to fusion polypeptides comprising a VcLp15 peptide sequence and a chaperone, to their use as an additive in an immunoassay for said reduction of interferences and for minimizing false positive results and to a reagent kit for detecting antibodies against Treponema pallidum antigens in an isolated sample comprising a TpN17 antigen and said VcLp15-chaperone fusion polypeptide.
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