公开(公告)号：US11112365B2

公开(公告)日：2021-09-07

申请号：US15909295

申请日：2018-03-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.

公开(公告)号：US20180106821A1

公开(公告)日：2018-04-19

申请号：US15843867

申请日：2017-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Vollenweider ,  Gottlieb Schacher ,  Goran Savatic ,  Marco Maetzler ,  Christoph Ludwig ,  Christian Loewenstein ,  Yves Laloux ,  Rik Harbers ,  Matthias Edelmann ,  Andreas Drechsler

IPC: G01N35/04

CPC classification number: G01N35/04 ,  G01N2035/0406 ,  G01N2035/0477 ,  G01N2035/0498

Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.

公开(公告)号：US11353471B2

公开(公告)日：2022-06-07

申请号：US15376704

申请日：2016-12-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Marcel Thomann

IPC: G01N33/48 ,  G01N33/50 ,  G01N35/00 ,  G01N21/47 ,  G01N21/25 ,  G01N21/31 ,  G01N21/27 ,  G01N21/55 ,  G01N35/02

Abstract: A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.

公开(公告)号：US20190004075A1

公开(公告)日：2019-01-03

申请号：US16105121

申请日：2018-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedrich Ackermann ,  Andreas Calatzis ,  Rik Harbers ,  Roland Hutter ,  Jean-Pierre Bolliger ,  Theresa Kitcoff ,  Patrick Sascha Labud

IPC: G01N35/00 ,  B01L9/00 ,  G01N35/04 ,  G01N35/10

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

公开(公告)号：US10082517B2

公开(公告)日：2018-09-25

申请号：US15084663

申请日：2016-03-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedrich Ackermann ,  Andreas Calatzis ,  Rik Harbers ,  Roland Hutter ,  Jean-Pierre Bolliger ,  Theresa Kitcoff ,  Patrick Sascha Labud

IPC: G01N35/00 ,  B01L9/00 ,  G01N35/10 ,  G01N35/04

CPC classification number: G01N35/00663 ,  B01L9/00 ,  B01L2200/025 ,  G01N35/00693 ,  G01N35/00722 ,  G01N35/0092 ,  G01N35/04 ,  G01N35/1002 ,  G01N35/1009 ,  G01N35/1016 ,  G01N35/1079 ,  G01N2035/00425 ,  G01N2035/00673 ,  G01N2035/00891 ,  G01N2035/0094 ,  G01N2035/0406 ,  G01N2035/1025

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

公开(公告)号：US09945787B2

公开(公告)日：2018-04-17

申请号：US13737523

申请日：2013-01-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/00 ,  G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

CPC classification number: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/255

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.