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公开(公告)号:US08828988B2
公开(公告)日:2014-09-09
申请号:US13731753
申请日:2012-12-31
申请人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号: A61K31/397 , A61K31/497 , A61K31/435
CPC分类号: C07D221/18
摘要: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20120135968A1
公开(公告)日:2012-05-31
申请号:US13319298
申请日:2010-05-07
申请人: Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
发明人: Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
IPC分类号: A61K31/65 , C07D207/09 , C07D295/185 , C07D211/14 , C07D211/58 , C07D209/44 , C07D205/04 , C07D295/155 , C07D209/52 , C07D213/56 , C07D207/14 , C07D471/10 , C07D307/22 , C07D307/16 , C07D487/08 , C07D217/20 , C07D279/12 , C07D225/02 , C07D223/14 , C07D223/08 , C07D223/16 , A61P31/04 , C07D295/26 , C07D241/08 , C07D211/62 , C07D401/04 , C07D221/20 , C07D209/42 , C07C237/26
CPC分类号: C07D471/10 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/24 , C07C2602/42 , C07C2602/50 , C07C2603/46 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/14 , C07D207/16 , C07D209/04 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/14 , C07D223/32 , C07D261/20 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/26 , C07D307/22 , C07D401/04 , C07D413/06
摘要: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US08822472B2
公开(公告)日:2014-09-02
申请号:US13069670
申请日:2011-03-23
申请人: Roger B. Clark , Daniel Elbaum
发明人: Roger B. Clark , Daniel Elbaum
IPC分类号: A61K31/497 , C07D401/08 , C07D401/12 , C07D413/08 , C07D413/12 , C07D405/14 , C07D241/04 , C07D401/14 , C07D417/14 , C07D513/14 , C07D413/14
CPC分类号: A61K31/496 , A61K31/495 , A61K31/5377 , A61K45/06 , C07D241/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/04 , C07D513/04 , C07D513/14
摘要: Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
摘要翻译: 公开了作为α7nAChR激动剂的新型哌嗪衍生物。 还公开了药物组合物,治疗炎性病症的方法,治疗CNS病症的方法,抑制哺乳动物细胞释放细胞因子的方法和制备新化合物的方法。
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公开(公告)号:US20130345178A1
公开(公告)日:2013-12-26
申请号:US13731753
申请日:2012-12-31
申请人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Ronn
发明人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Ronn
IPC分类号: C07D221/18
CPC分类号: C07D221/18
摘要: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20120108569A1
公开(公告)日:2012-05-03
申请号:US13319307
申请日:2010-05-07
申请人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号: A61K31/497 , A61P31/04 , A61K31/435 , C07D221/18 , C07D401/04
CPC分类号: C07D221/18
摘要: The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US09315451B2
公开(公告)日:2016-04-19
申请号:US13319298
申请日:2010-05-07
申请人: Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
发明人: Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
IPC分类号: A61K31/65 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D209/04 , C07D209/44 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/32 , C07D295/13 , C07D295/15 , C07D295/155
CPC分类号: C07D471/10 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/24 , C07C2602/42 , C07C2602/50 , C07C2603/46 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/14 , C07D207/16 , C07D209/04 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/14 , C07D223/32 , C07D261/20 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/26 , C07D307/22 , C07D401/04 , C07D413/06
摘要: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US08367654B2
公开(公告)日:2013-02-05
申请号:US13319307
申请日:2010-05-07
申请人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
发明人: Roger B. Clark , Minsheng He , Louis Plamondon , Xiao-Yi Xiao , Magnus P. Rönn
IPC分类号: A61K31/397 , A61K31/497 , A61K31/435 , C07D403/02 , C07D221/18 , C07D205/04
CPC分类号: C07D221/18
摘要: The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20100105671A1
公开(公告)日:2010-04-29
申请号:US12462795
申请日:2009-08-07
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/535 , C07D261/20 , C07D265/30 , C07D207/04 , A61K31/42 , A61K31/40 , A61P31/04
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)化合物及其治疗用途的药物组合物。
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公开(公告)号:US08796245B2
公开(公告)日:2014-08-05
申请号:US13718909
申请日:2012-12-18
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/65 , C07C237/26 , C07D205/04 , C07D231/14 , C07D207/12 , C07D213/82 , C07D295/088 , C07D249/04 , C07D261/20 , C07D311/08 , C07D213/74 , C07D209/94 , C07D207/09 , C07D413/12 , C07D295/26 , C07D207/10 , C07D211/60 , C07D231/56 , C07D207/34 , C07D211/76 , C07D207/16 , C07D207/14 , C07D295/15 , A61K45/06 , C07D333/34 , C07D233/61 , C07D333/38 , C07D277/56 , C07D213/81 , C07D239/42 , C07D207/08 , C07D231/12 , C07D261/18 , C07D257/04
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20120302527A1
公开(公告)日:2012-11-29
申请号:US13570837
申请日:2012-08-09
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其可药用盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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