公开(公告)号：US20060058338A1

公开(公告)日：2006-03-16

申请号：US10538355

申请日：2003-12-15

申请人： Alastair Denholm ,  Thomas Keller ,  Clive McCarthy ,  Neil Press ,  Roger Taylor

发明人： Alastair Denholm ,  Thomas Keller ,  Clive McCarthy ,  Neil Press ,  Roger Taylor

IPC分类号： C07D471/02 ,  A61K31/4745

CPC分类号： C07D471/04

摘要： Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-α release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

摘要翻译： 式I化合物

公开(公告)号：US5730446A

公开(公告)日：1998-03-24

申请号：US492596

申请日：1995-06-20

申请人： Roger Taylor ,  Pierre Mader ,  Alain Lamon

发明人： Roger Taylor ,  Pierre Mader ,  Alain Lamon

IPC分类号： B60J5/00 ,  B05B15/04 ,  B60J10/00 ,  B60R13/04 ,  B60R13/06 ,  F16J15/10 ,  F16J15/14 ,  F16J15/00

CPC分类号： B05B15/0468 ,  B05B15/0456 ,  B05B15/0462 ,  B60J10/35 ,  B60J10/45 ,  B60R13/043 ,  B60R13/06 ,  F16J15/14

摘要： A sealing strip (5) for a hem flange between two panels (for example, the inner and outer panels (1, 3) of a vehicle door) comprises an inner portion (9) of a tacky, sealing material with an outer part (10) of a non-tacky material, providing the strip with a rounded, shape-retaining, outer surface. To seal the hem flange, the strip (5) is pressed into place along the edge of the flange so that the inner surface (7) of the strip adheres to the panels and the rounded outer surface (10) extends from one panel to the other and covers the tacky material.

摘要翻译： 用于两个面板（例如车门的内板和外板（1,3））之间的下凸缘的密封条（5）包括具有外部部分的粘性密封材料的内部部分（9） 10）的非粘性材料，为条带提供圆形，形状保持的外表面。 为了密封下摆法兰，条带（5）沿着凸缘的边缘被压入到位，使得带的内表面（7）粘附到面板上，圆形的外表面（10）从一个面板延伸到 其他和覆盖的粘性材料。

公开(公告)号：US07459302B2

公开(公告)日：2008-12-02

申请号：US10261751

申请日：2002-10-01

申请人： Taylor Reid ,  Roger Taylor ,  Larry Brown

发明人： Taylor Reid ,  Roger Taylor ,  Larry Brown

IPC分类号： C12M1/38

CPC分类号： B01L7/52 ,  B01L2200/142 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/1805 ,  Y10S435/809

摘要： The invention relates to an apparatus and methods for preventing condensation on the interior surfaces of sample tubes which are being exposed to temperature cycles, such as during a PCR amplification reaction. In particular, the invention relates to apparatus comprising a sample block comprising a plurality of sample wells for receiving sample tubes and heating elements disposed in the sample wells for heating at least a portion of the sides of sample tubes (e.g., at least the portion which forms the head space after a tube is filled with a PCR reaction mixture). In a preferred aspect, the sample block is part of a thermocycling device for performing PCR and the side-wall heater is used to enhance uniformity and speed of amplification reactions. For example, by decreasing or eliminating condensation, signal strength jumps in a real-time PCR assay can be minimized as can reaction non-homogeneity.

摘要翻译： 本发明涉及一种用于防止在诸如PCR扩增反应期间暴露于温度循环的样品管的内表面上的冷凝的装置和方法。 特别地，本发明涉及包括样品块的装置，其包括多个用于接收样品管的样品孔和设置在样品阱中的加热元件，用于加热样品管的至少一部分侧面（例如，至少部分 在管填充PCR反应混合物后形成顶部空间）。 在优选的方面，样品块是用于进行PCR的热循环装置的一部分，并且侧壁加热器用于增强扩增反应的均匀性和速度。 例如，通过减少或消除冷凝，实时PCR测定中的信号强度跳跃可以如反应非均匀性那样最小化。

公开(公告)号：US20070249586A1

公开(公告)日：2007-10-25

申请号：US11823622

申请日：2007-06-27

申请人： Bernard Cuenoud ,  Robin Fairhurst ,  Roger Taylor ,  David Beattie

发明人： Bernard Cuenoud ,  Robin Fairhurst ,  Roger Taylor ,  David Beattie

IPC分类号： A61K31/428 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/55 ,  C07D417/02

CPC分类号： C07D417/12 ,  A61K31/428 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D277/68

摘要： Compounds of formula (I) in free or salt or solvate form, wherein X has the meaning indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中X具有说明书中指出的含义，可用于治疗通过β2 - 肾上腺素受体激活而预防或缓解的病症。 还描述了含有化合物的药物组合物和用于制备化合物的方法。

公开(公告)号：US20070194247A1

公开(公告)日：2007-08-23

申请号：US11510520

申请日：2006-08-25

申请人： Taylor Reid ,  Roger Taylor

发明人： Taylor Reid ,  Roger Taylor

IPC分类号： G01J1/58 ,  G01T1/10 ,  H01L31/14 ,  H01J40/14 ,  F21V9/16

CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2201/062 ,  G01N2201/0642 ,  G01N2201/101 ,  H01L31/167 ,  H01L2224/48472 ,  H01L2924/10253 ,  H01L2924/3025 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2924/00

摘要： A compact optical module for fluorescence excitation and detection and methods for using same are disclosed. An apparatus for detecting fluorescence includes a substrate base, a detector adjacent to the substrate base for determining the amount of fluorescence, an emission filter adjacent to the detector, a light source for emitting an excitation light, the light source engaging the emission filter, and a cover formed over the detector, the emission filter, and the light source.

摘要翻译： 公开了用于荧光激发和检测的紧凑型光学模块及其使用方法。 用于检测荧光的装置包括：基板，与基板基板相邻的用于确定荧光量的检测器，与检测器相邻的发射滤光器，用于发射激发光的光源，与发射滤光器接合的光源;以及 形成在检测器，发射滤光器和光源上的盖。

公开(公告)号：US20070114444A1

公开(公告)日：2007-05-24

申请号：US11451903

申请日：2006-06-12

申请人： Taylor Reid ,  Roger Taylor ,  Kenneth Zajac

发明人： Taylor Reid ,  Roger Taylor ,  Kenneth Zajac

IPC分类号： G01T1/10 ,  G01B9/10 ,  G01J1/58 ,  F21V9/16

CPC分类号： G01J3/10 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0612 ,  G01N2201/062

摘要： A system and method for fluorescence excitation and detection having distinct optical paths is disclosed. A system for detecting fluorescence comprises a light source that emits an excitation light into an illumination tube; a plurality of collection optics located around an aperture in the illumination tube for collecting fluorescence; and a detector for determining the amount of fluorescence. A method for detecting fluorescence comprises emitting an excitation light from a light source into an illumination tube; directing the excitation light to an excitation filter; illuminating a sample with the excitation light to generate an emission light; and detecting the optical characteristics of the emission light using a plurality of collection optics located around the illumination tube.

摘要翻译： 公开了具有不同光路的用于荧光激发和检测的系统和方法。 用于检测荧光的系统包括将激发光发射到照明管中的光源; 多个收集光学器件，位于照明管中用于收集荧光的孔周围; 以及用于确定荧光量的检测器。 检测荧光的方法包括将来自光源的激发光发射到照明管中; 将激发光引导到激发滤光器; 用激发光照射样品以产生发射光; 以及使用位于照明管周围的多个收集光学器件来检测发射光的光学特性。

公开(公告)号：US20070066607A1

公开(公告)日：2007-03-22

申请号：US10552023

申请日：2004-04-02

申请人： Robin Fairhurst ,  David Sandham ,  David Beattie ,  Ian Bruce ,  Bernard Cuenoud ,  Reamonn Madden ,  Neil Taylor ,  Roger Taylor ,  Katharine Turner ,  Simon Watson

发明人： Robin Fairhurst ,  David Sandham ,  David Beattie ,  Ian Bruce ,  Bernard Cuenoud ,  Reamonn Madden ,  Neil Taylor ,  Roger Taylor ,  Katharine Turner ,  Simon Watson

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/496 ,  A61K31/4709 ,  C07D265/36 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D215/227 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula I free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

摘要翻译： 式I的游离或盐形式的化合物，其中-CY-，R 1和R 2是G具有说明书中指出的含义，可用于治疗 通过β2 - 肾上腺素受体的激活而被预防或缓解。 还描述了含有化合物的药物组合物和制备该化合物的方法。