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公开(公告)号：US5314502A
公开(公告)日：1994-05-24
申请号：US956547
申请日：1992-10-02
CPC分类号： A61N1/044 , A61N1/303 , A61N1/325 , H01M10/4257 , H03K17/30 , H03K17/96 , A61N1/0448 , H01M2/1044 , H01M2/1066
摘要： An electrically powered iontophoretic delivery device is provided. The device includes a pair of electrode assemblies (41, 43) and a source of electrical power (30) connected thereto. Circuitry (60) is provided including an activation circuit (62) and a power generating circuit (70). Before use, neither the power generating circuit (70) nor the activation circuit (62) draw current from the power source (30). When the device is placed on the body (50) and electrical contact is established between the two electrode assemblies (41, 43), the activation circuit (62) is closed causing the power generating circuit (70) to be activated, thereby activating the device. The circuitry (60) improves the shelf-life of the device by minimizing current drain from the battery (30) before use.
摘要翻译： 提供电动离子电渗输送装置。 该装置包括一对电极组件（41,43）和与其连接的电力源（30）。 电路（60）具有启动电路（62）和发电电路（70）。 在使用之前，发电电路（70）和激活电路（62）都不从电源（30）吸取电流。 当装置放置在主体（50）上并且在两个电极组件（41,43）之间建立电接触时，激活电路（62）闭合，使得发电电路（70）被激活，从而激活 设备。 电路（60）通过最小化使用前电池（30）的电流消耗来改善器件的保质期。
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12.发明授权Reservoir and a series of related reservoirs for use in an electrotransport drug delivery device and devices comprised thereof 有权水库和一系列用于电输送药物输送装置的相关储存器及其组成的装置公开(公告)号：US06975902B2
公开(公告)日：2005-12-13
申请号：US10609211
申请日：2003-06-27
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of the same reservoir configurations and drug formulations. A method of making a reservoir and a family of reservoirs and incorporating them into an electrotransport system is disclosed.
摘要翻译： 提供了储存器和一系列储存器，其设计成与单个控制器一起使用以提供广泛的治疗药物递送方案，同时保持许多相同的储存器构型和药物制剂。 公开了一种制造储存器和一系列储存器并将其并入到电输送系统中的方法。
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公开(公告)号：US06842640B2
公开(公告)日：2005-01-11
申请号：US10253419
申请日：2002-09-25
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device (10) for delivering therapeutic agents includes and adjustable voltage boost multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage VW having a value just sufficient to provide the desired therapeutic current level II through the electrodes (108, 112), at least of which contains the therapeutic agent to be delivered.
摘要翻译： 用于递送治疗剂的电输送装置（10）包括用于将来自电源（102,202）的电压升高到具有刚好足以提供所需治疗剂的值的工作电压VW的可调升压多重控制器（100,200） 电流水平II通过电极（108,112），其至少包含待递送的治疗剂。
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14.发明授权Iontophoretic drug delivery system with two-stage delivery profile 失效具有两级交付配置文件的IOPOPHORETIC DRUG DELIVERY SYSTEM
公开(公告)号：US5207752A
公开(公告)日：1993-05-04
申请号：US671306
申请日：1991-03-21
CPC分类号： A61N1/0428 , A61N1/325
摘要： A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level to maintain a desired steady-state therapeutic level of the agent. One embodiment provides that the initial interval is maintained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief interval of increased iontophoretic current level to attain a brief interval of increased dosage.
摘要翻译： 两阶段离子电渗药物递送系统提供离子电渗电流在第一水平上递送第一预定间隔，以将治疗剂快速引入血流中，然后还原至第二较低水平，以保持所需的稳态治疗水平 中介。 一个实施方案规定，初始间隔保持足够长以提供峰值剂量，之后电流被切断以允许试剂浓缩在血流中，从而启动离子电渗电流的维持水平。 另一个实施方案提供了患者可以选择性地启动增加的离子电渗电流水平的短暂间隔以获得增加剂量的短暂间隔。
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公开(公告)号：US4725263A
公开(公告)日：1988-02-16
申请号：US891081
申请日：1986-07-31
申请人： Larry A. McNichols , John D. Badzinski , Joseph B. Phipps , Gary A. Lattin , Paul D. Sorenson , Rama Padmanabhan
发明人： Larry A. McNichols , John D. Badzinski , Joseph B. Phipps , Gary A. Lattin , Paul D. Sorenson , Rama Padmanabhan
CPC分类号： A61N1/325 , A61N1/0428 , H05K1/0293 , A61N1/0432 , H05K1/029 , H05K1/144 , H05K1/189 , H05K2201/09127 , H05K2201/10037 , H05K2201/10212 , H05K2203/0228 , H05K2203/175
摘要： An iontophoresis device including a control module and a disposable electrode module. The control module includes a flexible printed circuit board carrying the battery and other electrical components. The control module is so configured that by trimming it along one of several labeled lines, various current levels may be selected. Trimming the control module provides a simple method for varying the dosage of the drug delivered by the iontophoresis device and simultaneously provides an easily readable visual indicator of the dosage level.
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公开(公告)号：US4476873A
公开(公告)日：1984-10-16
申请号：US415042
申请日：1982-09-03
CPC分类号： A61B8/4209 , A61B8/00 , A61B8/0858 , A61B8/4245
摘要： An ultrasound scanning system particularly adapted for imaging skeletal structure, such as the spinal column. An ultrasound scanning head for generating ultrasound waves and for receiving reflected ultrasound signals is mounted on a transporter for moving it linearily along the spine between a cervical reference point and a sacral reference point. A position transducer monitors the position of the transducer along the spine and a counter measures the time between the ultrasound pulse and its echo to determine the distance from the transducer face to the tissue interface responsible for generating the echo. The distance and range data is smoothed and analyzed in a digital computer using algorithms that distinguish between the echoes received from bone and other tissue such as lung tissue. The bone data is further processed via computer to produce a visual representation of the spine and rib structure sufficient for the diagnosis of spinal misalignment characteristic of scoliosis.
摘要翻译： 一种超声扫描系统，特别适用于成像骨骼结构，如脊柱。 用于产生超声波并用于接收反射超声信号的超声波扫描头安装在运送器上，用于沿着颈部参考点和骶骨参考点之间的脊线线性移动。 位置传感器监测沿着脊柱的换能器的位置，并且计数器测量超声脉冲与其回波之间的时间，以确定从换能器面到负责产生回波的组织界面的距离。 距离和范围数据在数字计算机中平滑和分析，使用区分从骨骼和其他组织（例如肺组织）接收的回波的算法。 通过计算机进一步处理骨数据，以产生脊柱和肋骨结构的视觉表示，足以诊断脊柱侧凸的脊柱不对准特征。
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公开(公告)号：US4458693A
公开(公告)日：1984-07-10
申请号：US243229
申请日：1981-03-13
CPC分类号： H04M11/002 , Y10S128/904
摘要： Apparatus and technique for monitoring physiological parameters. An acoustic sensor or microphone is placed in close proximity to the chest of a patient having one or two prosthetic heart valves. These heart valves produce clicks characteristic of opening and closing action. The acoustic sensor picks up the sound of these clicks and transfers them as electrical energy to a transmitter unit. The transmitter unit processes the analog signal, converts it to a digital signal and establishes the key timing factors involved. This digital data is stored in a memory buffer within the transmitter. Subsequently, this information is modulated and placed on telephone lines for transmission to a central monitoring site. At the monitoring site a demodulator returns the data to baseband digital signals. A computer at the central monitoring site displays the information in the time domain and also converts the information for display in the frequency domain.
摘要翻译： 用于监测生理参数的装置和技术。 声学传感器或麦克风放置在靠近具有一个或两个假体心脏瓣膜的患者的胸部。 这些心脏瓣膜产生打开和关闭动作的特征。 声学传感器拾取这些点击的声音，并将其作为电能转移到发射器单元。 发射机单元处理模拟信号，将其转换为数字信号，并确定所涉及的关键时序因素。 该数字数据存储在发送器内的存储器缓冲器中。 随后，将该信息调制并放置在电话线路上，以便传输到中央监控站点。 在监控点，解调器将数据返回到基带数字信号。 中央监控点的计算机显示时域中的信息，并且将信息转换为频域显示。
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