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公开(公告)号：US10048272B2
公开(公告)日：2018-08-14
申请号：US15013102
申请日：2016-02-02
Applicant: STC.UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: A61K31/497 , A61K31/517 , A61K31/17 , G01N33/68 , C07D403/14 , A61K31/496 , A61K45/06 , C07C275/28 , C40B30/02 , G01N33/74 , A61K38/00 , C07D241/08 , C07K1/04
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
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公开(公告)号：US20180118761A1
公开(公告)日：2018-05-03
申请号：US15568931
申请日：2016-04-25
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Said M. Sebti , Yangmei Li , Richard A. Houghten
IPC: C07D513/04 , A61P35/00
Abstract: Compositions and methods for inhibits the binding of GTP to oncogenic mutant KRas are disclosed. These compositions may be used in method to treat a subject with cancer. In particular, the compositions may be used to treat cancers involving overactive Ras signaling.
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公开(公告)号：US20150150980A1
公开(公告)日：2015-06-04
申请号：US14622660
申请日：2015-02-13
Inventor： Andrea Leone-Bay , Richard A. Houghten , Joseph J. Guarneri , Grayson W. Stowell
CPC classification number: A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
Abstract translation: 公开了治疗疼痛的方法和组合物。 所述组合物基于包含二酮哌嗪的微粒和止痛活性剂的干燥粉末。 组合物中的镇痛剂包含一种或多种肽止痛剂或其衍生物，其使用包含干粉吸入器和镇痛组合物的肺吸入药物递送系统施用于受试者。 本发明组合物产生与当前阿片样物质治疗相关的较少副作用。
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公开(公告)号：US11352370B2
公开(公告)日：2022-06-07
申请号：US16927517
申请日：2020-07-13
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Said M. Sebti , Yangmei Li , Richard A. Houghten
IPC: C07D221/16 , C07D401/04 , C07D401/14 , A61K31/429 , A61P35/00 , C07D513/04
Abstract: Compositions and methods for inhibits the binding of GTP to oncogenic mutant KRas are disclosed. These compositions may be used in method to treat a subject with cancer. In particular, the compositions may be used to treat cancers involving overactive Ras signaling.
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公开(公告)号：US20210115063A1
公开(公告)日：2021-04-22
申请号：US16927517
申请日：2020-07-13
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Said M. Sebti , Yangmei Li , Richard A. Houghten
IPC: C07D513/04 , A61K31/429 , A61P35/00
Abstract: Compositions and methods for inhibits the binding of GTP to oncogenic mutant KRas are disclosed. These compositions may be used in method to treat a subject with cancer. In particular, the compositions may be used to treat cancers involving overactive Ras signaling.
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Patent Agency Ranking
公开(公告)号：US10899793B2
公开(公告)日：2021-01-26
申请号：US15605213
申请日：2017-05-25
Inventor： Carrie Haskell-Luevano , Skye Ross Doering , Jon R. Appel , Marc A. Giulianotti , Richard A. Houghten , Clemencia Pinilla , Radleigh G. Santos
IPC: C07K5/10 , A61K38/00 , A61K38/07 , C07K14/575
Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(═O)—W—X—Y—Z—N(R2)2 (I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
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公开(公告)号：US10711014B2
公开(公告)日：2020-07-14
申请号：US16540757
申请日：2019-08-14
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Said M. Sebti , Yangmei Li , Richard A. Houghten
IPC: A61K31/429 , A61K35/00 , C07D513/04 , A61P35/00
Abstract: Compositions and methods for inhibits the binding of GTP to oncogenic mutant KRas are disclosed. These compositions may be used in method to treat a subject with cancer. In particular, the compositions may be used to treat cancers involving overactive Ras signaling.
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公开(公告)号：US10421764B2
公开(公告)日：2019-09-24
申请号：US15568931
申请日：2016-04-25
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Said M. Sebti , Yangmei Li , Richard A. Houghten
IPC: C07D221/16 , C07D401/04 , C07D401/14 , C07D513/04 , A61K31/429 , A61P35/00
Abstract: Compositions and methods for inhibits the binding of GTP to oncogenic mutant KRas are disclosed. These compositions may be used in method to treat a subject with cancer. In particular, the compositions may be used to treat cancers involving overactive Ras signaling.
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公开(公告)号：US09610351B2
公开(公告)日：2017-04-04
申请号：US14622660
申请日：2015-02-13
Inventor： Andrea Leone-Bay , Richard A. Houghten , Joseph J. Guarneri , Grayson W. Stowell
IPC: A61K38/07 , A61K38/08 , A61K9/14 , C07K5/10 , C07K7/06 , A61K47/22 , A61K38/04 , A61K9/00 , A61K31/495 , A61K31/198 , A61K31/401 , A61K31/405 , C07K5/107
CPC classification number: A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
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20.发明申请HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROM SCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES 审中-公开从组合混合型图书馆筛选出的高亲和力小分子甲基化受体配体公开(公告)号：US20160320402A1
公开(公告)日：2016-11-03
申请号：US15013102
申请日：2016-02-02
Applicant: STC.UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: G01N33/68 , A61K31/17 , A61K31/496 , C40B30/02 , G01N33/74
CPC classification number: G01N33/6845 , A61K31/17 , A61K31/496 , A61K38/00 , A61K45/06 , B01J2219/00585 , C07C275/28 , C07D241/08 , C07D403/14 , C07K1/047 , C40B30/02 , G01N33/74 , G01N2333/726 , A61K2300/00
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
Abstract translation: 本发明还提供新的FPR1和FPR2配体（例如激动剂和拮抗剂），相关的药物组合物和治疗FPR1和FPR2相关疾病的方法。
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