公开(公告)号：US09987427B1

公开(公告)日：2018-06-05

申请号：US14746301

申请日：2015-06-22

Applicant: Sandia Corporation

Inventor： Ronen Polsky ,  Philip Rocco Miller ,  Thayne L. Edwards

IPC: A61M5/172 ,  A61B10/00 ,  A61B5/145 ,  A61M37/00 ,  A61B5/157

CPC classification number: A61M5/1723 ,  A61B5/157 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2202/048 ,  A61M2202/30

Abstract: The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.

公开(公告)号：US20160095541A1

公开(公告)日：2016-04-07

申请号：US14965755

申请日：2015-12-10

Applicant: The Regents of the University of California ,  North Carolina State University ,  Sandia Corporation

Inventor： Joseph Wang ,  Joshua Ray Windmiller ,  Roger Narayan ,  Philip Miller ,  Ronen Polsky ,  Thayne L. Edwards

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7282 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2562/028 ,  A61B2562/046 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/003 ,  G01N33/48785

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract translation: 公开了用于生物传感和药物递送技术的方法，结构和系统。 在一个方面，用于检测分析物和/或将生物化学物质释放到生物流体中的装置可以包括中空针阵列，其中每个针包括突出的针结构，其包括形成中空内部的外壁和在 暴露中空内部的突出针结构的末端以及外壁内的探针与通过开口与探针接触以产生探针感测信号的一种或多种化学或生物物质相互作用，并产生阵列 分别耦合到中空针阵列的探针的导线，每根线都是导电的，以传输由相应探针产生的探针感测信号。

公开(公告)号：US20150024414A1

公开(公告)日：2015-01-22

申请号：US14157378

申请日：2014-01-16

Applicant: Sandia Corporation

Inventor： Jason C. Harper ,  Thayne L. Edwards ,  Bryan Carson ,  Melissa Finley ,  William Arndt

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  B01L3/502738 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0633 ,  F16K31/086 ,  F16K99/003 ,  F16K99/0046 ,  F16K2099/0084 ,  Y10T137/87917

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract translation: 本发明部分地涉及用于片上放大和/或检测各种靶标的方法和装置，包括生物靶标和任何可扩增的靶标。 在一些实例中，微培养装置包括一次性常闭的流体阀，其最初通过结合到粘合剂涂层的阀元件保持在关闭位置。 阀门使用磁力打开。 阀元件包括磁性材料或金属。 这样的设备和方法对于现场或实时检测目标是有用的，特别是在有限的资源设置中。