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11.发明申请公开(公告)号：US20150218243A1
公开(公告)日：2015-08-06
申请号：US14615224
申请日：2015-02-05
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Jae Il Lee , Eunji Kang , Jungmin Lee
IPC: C07K14/47
CPC classification number: C07K14/4738 , A61K38/00 , C07K14/4703
Abstract: A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a method for preventing and/or treating cancer comprising administering the p15 protein variant to a subject.
Abstract translation: p15蛋白质变体; 编码p15蛋白变体的多核苷酸; 制备p15蛋白变体的方法; 包含该p15蛋白质变体的药物组合物; 以及用于预防和/或治疗癌症的方法，其包括将p15蛋白质变体施用于受试者。
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公开(公告)号：US09617344B2
公开(公告)日：2017-04-11
申请号：US14794542
申请日：2015-07-08
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jae Il Lee , Soshin Ahn , Jung Min Kim , Jungmin Lee , Jung-Hoon Lee
IPC: A61K38/00 , A61K39/00 , A61K39/395 , A61K38/16 , C12N5/00 , C12N15/00 , C07H21/04 , C07K16/00 , C12P21/08 , C07K16/30 , A61K47/48 , C07K16/28
CPC classification number: C07K16/30 , A61K38/00 , A61K47/6851 , C07K14/47 , C07K16/2863 , C07K2318/20 , C07K2319/10 , C07K2319/33 , C07K2319/50
Abstract: A fusion protein including a targeting moiety, a cleavage site, and a cell membrane penetrating domain, a conjugate including the fusion protein and a bioactive molecule, and methods employing the fusion protein and the conjugate are provided.
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公开(公告)号：US09522952B2
公开(公告)日：2016-12-20
申请号：US14482959
申请日：2014-09-10
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jieun Han , Jung Min Kim , Jae Il Lee
IPC: C07K16/00 , C07K16/18 , G01N33/574
CPC classification number: C07K16/18 , C07K2317/622 , G01N33/574 , G01N2333/4718 , G01N2800/24
Abstract: A polypeptide binding to Annexin A1, an antagonist against Annexin A1 including the polypeptide, an anti-Annexin A1 antibody including the polypeptide or an antigen-binding fragment thereof, and methods of preventing, treating and/or diagnosing a disease, including administering the antagonist and/or the antibody or an antigen-binding fragment thereof to a subject.
Abstract translation: 与膜联蛋白A1结合的多肽，包括多肽的膜联蛋白A1的拮抗剂，包含多肽的抗间质联蛋白A1抗体或其抗原结合片段，以及预防，治疗和/或诊断疾病的方法，包括施用拮抗剂 和/或抗体或其抗原结合片段。
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14.发明授权公开(公告)号：US09512193B2
公开(公告)日：2016-12-06
申请号：US14615224
申请日：2015-02-05
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Jae Il Lee , Eunji Kang , Jungmin Lee
CPC classification number: C07K14/4738 , A61K38/00 , C07K14/4703
Abstract: A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a method for preventing and/or treating cancer comprising administering the p15 protein variant to a subject.
Abstract translation: p15蛋白质变体; 编码p15蛋白变体的多核苷酸; 制备p15蛋白变体的方法; 包含该p15蛋白质变体的药物组合物; 以及用于预防和/或治疗癌症的方法，其包括将p15蛋白质变体施用于受试者。
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Patent Agency Ranking
公开(公告)号：US20150329847A1
公开(公告)日：2015-11-19
申请号：US14716275
申请日：2015-05-19
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jae Il Lee , Hye Yoon Kang , Dongkyu Shin , Jung Min Kim , Jungmin Lee
CPC classification number: A61K38/03 , A61K38/00 , A61K38/482 , A61K39/3955 , C07K4/00 , C07K16/2863 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/70 , C12N9/6467 , C12Y304/21079
Abstract: A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein.
Abstract translation: 包含粒酶B，细胞穿透肽，切割位点和靶向部分的融合蛋白，包含融合蛋白的细胞膜渗透用组合物和包含该融合蛋白的抗癌组合物。
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公开(公告)号：US09724378B2
公开(公告)日：2017-08-08
申请号：US14716275
申请日：2015-05-19
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jae Il Lee , Hye Yoon Kang , Dongkyu Shin , Jung Min Kim , Jungmin Lee
CPC classification number: A61K38/03 , A61K38/00 , A61K38/482 , A61K39/3955 , C07K4/00 , C07K16/2863 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/70 , C12N9/6467 , C12Y304/21079
Abstract: A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein.
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公开(公告)号：US09470677B2
公开(公告)日：2016-10-18
申请号：US14554955
申请日：2014-11-26
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jungmin Lee , Jae Il Lee , Soshin Ahn , Hye Yoon Kang
IPC: G01N33/574 , G01N33/50
CPC classification number: G01N33/502 , C12N5/0006 , C12N2501/998 , G01N2333/705 , G01N2500/10
Abstract: A cell having a surface coated with Annexin A1 (ANXA1), a method of detecting a substance binding to ANXA1 using the cell, and a method of preparing the cell are provided.
Abstract translation: 提供了具有被膜蛋白A1（ANXA1）包被的表面的细胞，使用该细胞检测与ANXA1结合的物质的方法以及制备该细胞的方法。
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公开(公告)号：US09365833B2
公开(公告)日：2016-06-14
申请号：US14502088
申请日：2014-09-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Eunji Kang , Hye Yoon Kang , Dongkyu Shin , Jae Il Lee , Jieun Han , Jung Min Lee
CPC classification number: C12N7/00 , A61K38/00 , C07K14/4746 , C07K2319/10 , C07K2319/73
Abstract: A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting HDM2- and/or HDMX using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.
Abstract translation: 亮氨酸拉链变体，编码亮氨酸拉链变体的多核苷酸，制备亮氨酸拉链变体的方法，使用亮氨酸拉链变体抑制HDM2-和/或HDMX的方法，以及预防和/或治疗癌症的方法 使用亮氨酸拉链变体。
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公开(公告)号：US20150119340A1
公开(公告)日：2015-04-30
申请号：US14527427
申请日：2014-10-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung Min Kim , Kyoung Hu Lee , Jae Il Lee , Jungmin Lee
CPC classification number: C12N15/87 , C07K2319/10
Abstract: A fusion peptide including a hydrophobic peptide and a basic peptide, a pharmaceutical composition including the fusion peptide, a cell membrane penetrating conjugate including the fusion peptide and a substance of interest, and a method for intracellular delivery of a substance of interest using the fusion peptide.
Abstract translation: 包括疏水性肽和碱性肽的融合肽，包含融合肽的药物组合物，包含融合肽的细胞膜穿透缀合物和感兴趣的物质，以及使用融合肽细胞内递送感兴趣物质的方法 。
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