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公开(公告)号：USD394223S
公开(公告)日：1998-05-12
申请号：US68004
申请日：1997-03-14
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公开(公告)号：US20080254998A1
公开(公告)日：2008-10-16
申请号：US10594182
申请日：2005-03-18
CPC分类号： G01N33/543 , G01N2400/00
摘要： A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof.
摘要翻译： 其中包含与糖链的醛基特异性反应的官能团的载体，以及应用了载体的聚合物颗粒和糖芯片及其用途。
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公开(公告)号：US20080097061A1
公开(公告)日：2008-04-24
申请号：US11660985
申请日：2005-07-07
IPC分类号： C08F20/04 , C07C49/203 , C07C69/52 , C07D207/46 , C07D233/02
CPC分类号： C08F220/60 , C07C291/04 , C08F222/1006
摘要： An oxylamino group-containing compound represented by the following formula: R1—B-A-B—R2, wherein R1 represents a polymerizable group, R2 represents an oxylamino group-containing group or an oxylamino derivative-containing group, B represents an ester linkage or an amide linkage, and A represents an optionally substituted alkylene group having 2 to 12 carbon atoms.
摘要翻译： 由下式表示的含氧基氨基的化合物：<？in-line-formula description =“In-line formula”end =“lead”？> R 1 -BABR < / SUP>，<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1表示可聚合基团R 2 表示含有氧基氨基的基团或含氧基氨基衍生物的基团，B表示酯键或酰胺键，A表示任选取代的碳原子数2〜12的亚烷基。
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14.发明授权公开(公告)号：US07223779B2
公开(公告)日：2007-05-29
申请号：US10504777
申请日：2003-06-26
IPC分类号： A61K31/44 , C07D211/40
CPC分类号： C07D491/04 , A61K31/445 , C07D211/96
摘要： A novel azasugar derivative, and a drug containing the same as an active ingredient are disclosed. The drug is useful for treatment of keratinocyte-proliferative diseases.
摘要翻译： 公开了一种新型的azasagar衍生物和含有其作为活性成分的药物。 该药物可用于治疗角化细胞增生性疾病。
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15.发明授权Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs 有权半乳糖神经酰胺类似物和β-葡糖脑苷脂酶激活剂，外用皮肤制剂和使用类似物活化β-葡糖脑苷脂酶的方法公开(公告)号：US07183261B2
公开(公告)日：2007-02-27
申请号：US10482110
申请日：2002-06-27
申请人： Rie Uematsu , Fumio Nakajima , Masahiro Yoshida , Kyoko Fukunaga , Mariko Hara , Shintaro Inoue , Shinichiro Nishimura
发明人： Rie Uematsu , Fumio Nakajima , Masahiro Yoshida , Kyoko Fukunaga , Mariko Hara , Shintaro Inoue , Shinichiro Nishimura
摘要： Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a β-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating β-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating β-glucocerebrosidase so that an improved effect in rough skin is also expected.
摘要翻译： 由下式（1）或（2）表示的半乳糖神经酰胺类似物。 （其中X和Y各自表示S或O，R 1和R 2各自表示各自具有9至35个碳原子的烷基或烯基，R SUP > 3 表示各自具有2〜30个碳原子的烷基或烯基。）提供易于获得的β-葡萄糖脑苷脂酶激活剂，以及外用皮肤制剂和β-葡萄糖脑苷脂酶活化方法 通过激活β-葡糖脑苷脂酶预期角质层传播屏障形成的改善，从而也预期在粗糙皮肤中的改善效果。
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公开(公告)号：US20060121559A1
公开(公告)日：2006-06-08
申请号：US11061536
申请日：2005-02-18
CPC分类号： C12P19/00 , B01J20/3242 , B01J2220/603 , C12N11/00 , C12P21/005 , C12P21/06
摘要： The present invention provides a sugar chain purification instrument which can continuously and efficiently purify the sugar chain. According to the present invention, the instrument includes an immobilized protease column in which a carrier which can be packed in the column and on which protease is immobilized is packed and an immobilized glycopeptidase column in which a carrier which can be packed in the column and on which glycopeptidase is immobilized is packed, these columns being connected in series, and the reaction is carried out while continuously passing a glycoprotein to be decomposed together with a suitable buffer solution through the above columns. The step of liberation of sugar chain from the glycoprotein is highly simplified and labor-saving, and liberation of the sugar chain can be moderately and simply performed.
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公开(公告)号：USD390137S
公开(公告)日：1998-02-03
申请号：US68003
申请日：1997-03-14
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公开(公告)号：US09340651B2
公开(公告)日：2016-05-17
申请号：US12309945
申请日：2007-08-06
申请人： Hideyuki Shimaoka , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
发明人： Hideyuki Shimaoka , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
IPC分类号： C08G63/91 , C08J3/24 , C07C233/20 , C07C281/02 , C08F8/30 , G01N33/53 , C08F122/38 , C07C271/08 , C08F222/10 , G01N30/02 , G01N30/88
CPC分类号： C08J3/24 , C07C233/20 , C07C271/08 , C07C281/02 , C08F8/30 , C08F122/38 , C08F2222/1013 , G01N33/5308 , G01N2030/027 , G01N2030/8813 , G01N2030/8836 , Y02P20/55 , Y10T428/2982 , C08F220/60
摘要： The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.
摘要翻译： 本发明提供一种制备样品的方法，其特征在于，通过在物质A的酰肼基和糖链的还原端之间形成腙将含有酰肼基团的物质A与糖链和/或糖衍生物结合， /或糖衍生物，从而能够通过简单的操作从含有糖链和/或糖衍生物的生物样品中分离和纯化分析样品的糖链和/或糖衍生物。
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19.发明授权公开(公告)号：US09139607B2
公开(公告)日：2015-09-22
申请号：US10540723
申请日：2003-12-25
IPC分类号： C07H1/08 , C07C239/20
CPC分类号： C07H1/08 , C07C239/20 , C07H1/06 , C07H3/06 , C07K1/14 , C07K14/77 , C07K14/79 , C07K16/00 , G01N33/5308 , G01N33/6842 , G01N2333/77 , G01N2333/79 , G01N2400/00 , G01N2560/00
摘要： The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance in a sample, comprising the steps of: a) contacting a sugar chain-trapping carrier comprising a substance which can specifically interact with sugar chains with the sample in a fluid phase under conditions that the sugar chain-trapping carrier can react with the sugar chains or sugar chain-containing substance; b) isolating a composite of the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance from the fluid phase; and c) exposing the composite to the conditions that the interaction between the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance is at least partially eliminated.
摘要翻译： 本发明提供可以与糖链特异性相互作用的物质。 此外，本发明提供了一种用于在样品中分离，浓缩或纯化糖链或含糖链物质的方法，包括以下步骤：a）使含糖链捕获载体与包含可特异性相互作用的物质 在链条捕获载体可以与糖链或含糖链物质反应的条件下，样品在液相中的糖链; b）从流体相中分离捕获糖链的载体和糖链或含糖链的物质的复合物; 以及c）将所述复合材料暴露于所述糖链捕获载体和所述糖链或含糖链物质之间的相互作用被至少部分消除的条件。
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公开(公告)号：US20090306291A1
公开(公告)日：2009-12-10
申请号：US12309945
申请日：2007-08-06
申请人： Hideyuki Shimaoka , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
发明人： Hideyuki Shimaoka , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
IPC分类号： C08G81/00
CPC分类号： C08J3/24 , C07C233/20 , C07C271/08 , C07C281/02 , C08F8/30 , C08F122/38 , C08F2222/1013 , G01N33/5308 , G01N2030/027 , G01N2030/8813 , G01N2030/8836 , Y02P20/55 , Y10T428/2982 , C08F220/60
摘要： The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.
摘要翻译： 本发明提供一种制备样品的方法，其特征在于，通过在物质A的酰肼基和糖链的还原端之间形成腙将含有酰肼基团的物质A与糖链和/或糖衍生物结合， /或糖衍生物，从而能够通过简单的操作从含有糖链和/或糖衍生物的生物样品中分离和纯化分析样品的糖链和/或糖衍生物。
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