公开(公告)号：US11958877B2

公开(公告)日：2024-04-16

申请号：US18178802

申请日：2023-03-06

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230407389A1

公开(公告)日：2023-12-21

申请号：US18449601

申请日：2023-08-14

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876

CPC classification number: C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.

公开(公告)号：US20240400602A1

公开(公告)日：2024-12-05

申请号：US18791082

申请日：2024-07-31

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are compounds and methods of using the same for the modifying a nucleic acid molecule.

公开(公告)号：US20240294764A1

公开(公告)日：2024-09-05

申请号：US18435635

申请日：2024-02-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Ada Tong ,  Megha Cila ,  Ronald Graham

IPC: C09B11/24 ,  A61K49/00 ,  C07H19/20 ,  C12Q1/6869

CPC classification number: C09B11/24 ,  A61K49/0041 ,  A61K49/0054 ,  C07H19/20 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are fluorescent compounds and methods of making and using thereof.

公开(公告)号：US11878993B2

公开(公告)日：2024-01-23

申请号：US18295770

申请日：2023-04-04

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230160001A1

公开(公告)日：2023-05-25

申请号：US17918072

申请日：2021-05-06

Applicant: Singular Genomics Systems, Inc.

Inventor： Ada Tong ,  Ronald Graham ,  Megha Cila ,  Eli N. Glezer ,  Zachary Terranova

IPC: C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6818

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

公开(公告)号：US20230101281A1

公开(公告)日：2023-03-30

申请号：US17882448

申请日：2022-08-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US10738072B1

公开(公告)日：2020-08-11

申请号：US16662781

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C12Q1/68 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US12215122B2

公开(公告)日：2025-02-04

申请号：US18522886

申请日：2023-11-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11987709B2

公开(公告)日：2024-05-21

申请号：US17882448

申请日：2022-08-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

CPC classification number: C09B62/365 ,  C09K11/06 ,  G01N33/582 ,  C09K2211/1018

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).