公开(公告)号：US10253152B2

公开(公告)日：2019-04-09

申请号：US14423150

申请日：2013-09-26

Applicant: Sofradim Production

Inventor： Sébastien Ladet ,  Nicolas Prost

IPC: B05B3/00 ,  C08J9/28 ,  A61L27/20 ,  C08J5/18 ,  A61L31/04 ,  A61L31/14

Abstract: The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mold in order to form a first sublayer, the surface of the first sublayer being left to the open air; b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; c) the first and second sublayers are subjected to a step of lyophilization, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

公开(公告)号：US20170165399A1

公开(公告)日：2017-06-15

申请号：US15116836

申请日：2015-02-18

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Nicolas Prost ,  Suzelei Montanari

IPC: A61L27/34 ,  A61L31/14 ,  D06N3/00 ,  A61L2/08 ,  D06B3/10 ,  A61L31/04 ,  A61L27/50

CPC classification number: A61L27/34 ,  A61L2/081 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3687 ,  A61L27/50 ,  A61L31/042 ,  A61L31/044 ,  A61L31/14 ,  A61L2420/02 ,  D06B3/10 ,  D06B2700/27 ,  D06N3/00 ,  D06N2201/02 ,  D06N2203/02 ,  D06N2205/16 ,  D10B2331/04 ,  D10B2509/00

Abstract: A method for manufacturing an implantable film and a prosthesis comprising such a film The present invention relates to a method for manufacturing a non porous film intended to be implanted in the human body, said method comprising the following steps: preparation of a first film, called intermediate film, via gelling of a starting solution comprising at least one polymer selected in the group consisting of collagen, glycosaminoglycans, and mixtures thereof, immersion of said intermediate film in an alkaline composition comprising at least one C1-C4 alcohol, drying of the film obtained at the end of the immersing step. The invention also relates to a method for manufacturing a prosthesis comprising a textile support and such a film.

公开(公告)号：US12257137B2

公开(公告)日：2025-03-25

申请号：US18107969

申请日：2023-02-09

Applicant: SOFRADIM PRODUCTION ,  Covidien LP

Inventor： Julie Lecuivre ,  Nicolas Prost ,  Nicholas Maiorino ,  Matthew Prescott ,  Thomas Corso

IPC: A61F2/00 ,  A61L27/16 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ε-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ε-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

公开(公告)号：US12070534B2

公开(公告)日：2024-08-27

申请号：US16717112

申请日：2019-12-17

Applicant: Sofradim Production

Inventor： Nicolas Prost ,  Delphine Petit ,  Xavier Bourges

IPC: A61L31/04 ,  A61F2/00 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/14 ,  B29C41/02 ,  B29C41/12 ,  B29C41/22 ,  B29C41/24 ,  C08J5/18 ,  C08J7/04 ,  C08L89/06

CPC classification number: A61L31/044 ,  A61F2/0063 ,  A61F2/0077 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  C08J5/18 ,  C08J7/0427 ,  C08L89/06 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2420/08 ,  B29C41/02 ,  B29C41/12 ,  B29C41/22 ,  B29C41/24 ,  C08J2389/06 ,  C08J2489/06 ,  A61L31/10 ,  C08L89/06

Abstract: The present invention relates to a surgical anti-adhesion barrier film comprising an oxidized collagen and a polyphosphate compound and to a surgical implant comprising a prosthetic fabric and such a film.

公开(公告)号：US09833546B2

公开(公告)日：2017-12-05

申请号：US15116836

申请日：2015-02-18

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Nicolas Prost ,  Suzelei Montanari

IPC: A61L27/50 ,  A61L31/14 ,  A61L27/34 ,  A61L31/04 ,  A61L2/08 ,  D06B3/10 ,  D06N3/00

CPC classification number: A61L27/34 ,  A61L2/081 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3687 ,  A61L27/50 ,  A61L31/042 ,  A61L31/044 ,  A61L31/14 ,  A61L2420/02 ,  D06B3/10 ,  D06B2700/27 ,  D06N3/00 ,  D06N2201/02 ,  D06N2203/02 ,  D06N2205/16 ,  D10B2331/04 ,  D10B2509/00

Abstract: A method for manufacturing an implantable film and a prosthesis comprising such a film The present invention relates to a method for manufacturing a non porous film intended to be implanted in the human body, said method comprising the following steps: preparation of a first film, called intermediate film, via gelling of a starting solution comprising at least one polymer selected in the group consisting of collagen, glycosaminoglycans, and mixtures thereof, immersion of said intermediate film in an alkaline composition comprising at least one C1-C4 alcohol, drying of the film obtained at the end of the immersing step. The invention also relates to a method for manufacturing a prosthesis comprising a textile support and such a film.

公开(公告)号：US20230263613A1

公开(公告)日：2023-08-24

申请号：US18107969

申请日：2023-02-09

Applicant: SOFRADIM PRODUCTION ,  Covidien LP

Inventor： Julie Lecuivre ,  Nicolas Prost ,  Nicholas Maiorino ,  Matthew Prescott ,  Thomas Corso

IPC: A61F2/00 ,  A61L31/14 ,  A61L31/06 ,  A61L27/16 ,  A61L27/18 ,  A61L27/58

CPC classification number: A61F2/0063 ,  A61L31/146 ,  A61L31/06 ,  A61L27/16 ,  A61L27/18 ,  A61L27/58 ,  A61F2250/0097 ,  A61F2002/009 ,  A61F2002/0068 ,  A61F2210/0004 ,  A61F2240/00

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising:



a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face,
a synthetic non porous biodegradable film comprising at least a copolymer of at least ε-caprolactone, said film covering at least part of said first face,
a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ε-caprolactone,

wherein said second face of said porous knit is left open to cell colonization.
The invention also relates to a method for forming such a prosthesis.

公开(公告)号：US20220346930A1

公开(公告)日：2022-11-03

申请号：US17868702

申请日：2022-07-19

Applicant: SOFRADIM PRODUCTION SAS

Inventor： Sebastien Francois ,  Michel Therin ,  Nicolas Prost

IPC: A61F2/00

Abstract: The present invention relates to a prosthesis (1) for hernia repair comprising a reinforcement layer (2), a first barrier layer (3) of anti-adhesion material covering at least a part of a surface of the reinforcement layer, and a second barrier layer of anti-adhesion material covering a remaining part of the surface of the reinforcement layer, the second barrier layer being formed of one or more flap member(s) (4).

公开(公告)号：US10820979B2

公开(公告)日：2020-11-03

申请号：US15963388

申请日：2018-04-26

Applicant: Sofradim Production

Inventor： Sébastien Ladet ,  Sebastien Francois ,  Nicolas Prost

IPC: A61F2/00

Abstract: Prosthesis (1) comprising a patch (2) made of biocompatible material, said patch having a generally plane geometric shape that defines two opposite faces, a centre, a length and a width of said patch, characterized in that said patch is provided, on one (2a) of its faces, with a single marking means (3) designed to indicate both the centre (C) of the patch and also the longitudinal direction of said patch.

公开(公告)号：US10743976B2

公开(公告)日：2020-08-18

申请号：US15169829

申请日：2016-06-01

Applicant: Sofradim Production ,  Covidien LP

Inventor： Julie Lecuivre ,  Nicolas Prost ,  Nicholas Maiorino ,  Matthew Prescott ,  Thomas Corso

IPC: A61F2/00 ,  A61L27/58 ,  A61L31/14 ,  A61L31/06 ,  A61L27/16 ,  A61L27/18

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ε-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ε-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

公开(公告)号：US20200222166A1

公开(公告)日：2020-07-16

申请号：US16838085

申请日：2020-04-02

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Michel Therin ,  Nicolas Prost

IPC: A61F2/00

Abstract: The present invention relates to a prosthesis (1) for hernia repair comprising a reinforcement layer (2), a first barrier layer (3) of anti-adhesion material covering at least a part of a surface of the reinforcement layer, and a second barrier layer of anti-adhesion material covering a remaining part of the surface of the reinforcement layer, the second barrier layer being formed of one or more flap member(s) (4).