-
公开(公告)号：US09051370B2
公开(公告)日：2015-06-09
申请号：US13814779
申请日：2011-08-10
申请人： Steffen Goletz , Antje Danielczyk
发明人： Steffen Goletz , Antje Danielczyk
IPC分类号： A61K39/395 , C07K16/28 , C12N5/10 , C12N15/11
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/565 , C07K2317/567
摘要： The present invention pertains to humanized anti-EGFR antibodies having antigen binding properties similar to those of the murine or chimeric anti-EGFR antibody from which they are derived. In particular, the present invention is directed to humanized anti-EGFR antibodies which are useful in the treatment of cancer.
摘要翻译： 本发明涉及具有与从其衍生的鼠抗体或嵌合抗EGFR抗体相似的抗原结合特性的人源化抗EGFR抗体。 特别地，本发明涉及可用于治疗癌症的人源化抗EGFR抗体。
-
公开(公告)号：US08642276B2
公开(公告)日：2014-02-04
申请号：US12818839
申请日：2010-06-18
申请人： Steffen Goletz , Uwe Karsten
发明人： Steffen Goletz , Uwe Karsten
CPC分类号： C07K14/4727 , A61K38/1735 , A61K39/0005 , A61K45/06 , A61K2039/505 , C07K16/3092 , C07K16/44
摘要： The present invention relates to a method for producing or identifying a MUC1 molecule which is able to generate an immune response in humans. The invention also relates to a method for producing or identifying a cell, cell lines or cell lysates containing a MUC1 molecule that is able to generate an immune response in humans. The invention further relates to methods for producing medicaments and diagnostic agents. Also disclosed is the use of the MUC1 molecules, cells or cell lysates obtained by means of the methods according to the invention for producing a medicament used for treating or preventing tumors. Further disclosed is a purified MUC1 molecule that can be obtained by means of the methods according to the invention and has an immunostimulating effect on humans. The invention additionally relates to the use of a MUC1 antibody for the production of a medicament used for treating or preventing tumors.
摘要翻译： 本发明涉及能够在人体中产生免疫应答的产生或鉴定MUC1分子的方法。 本发明还涉及产生或鉴定含有能够在人体中产生免疫应答的MUC1分子的细胞，细胞系或细胞裂解物的方法。 本发明还涉及生产药物和诊断剂的方法。 还公开了通过根据本发明的方法获得的MUC1分子，细胞或细胞裂解物用于产生用于治疗或预防肿瘤的药物的用途。 进一步公开的是可以通过本发明的方法获得并且对人类具有免疫刺激作用的纯化的MUC1分子。 本发明还涉及MUC1抗体用于制备用于治疗或预防肿瘤的药物的用途。
-
公开(公告)号：US20120329092A1
公开(公告)日：2012-12-27
申请号：US13575068
申请日：2011-01-25
申请人： Steffen Goletz , Lars Stöckl
发明人： Steffen Goletz , Lars Stöckl
CPC分类号： C07K1/36 , C07K14/505 , C12P21/005
摘要： The present invention relates to a process for the purification of a glycoprotein comprising subjecting a liquid containing said glycoprotein to the steps of: a) reverse phase chromatography, b) boronate affinity chromatography, and c) size exclusion chromatography. Also provided is a manufacturing process for producing a glycoprotein of interest.
摘要翻译： 本发明涉及一种用于纯化糖蛋白的方法，包括使含有所述糖蛋白的液体经受以下步骤：a）反相色谱，b）硼酸酯亲和层析，和c）尺寸排阻层析。 还提供了用于生产目的糖蛋白的制备方法。
-
14.发明申请PRODUCTION AND USE OF HUMAN CD124- AND CD-116-POSITIVE TUMOR CELL LINES IN THE PRODUCTION OF ALLOGENIC OR SEMI-ALLOGENIC IMMUNOTHERAPY AGENTS 有权人CD124和CD-116阳性肿瘤细胞系生产和使用生产同种异体免疫球蛋白公开(公告)号：US20120308607A1
公开(公告)日：2012-12-06
申请号：US13553157
申请日：2012-07-19
CPC分类号： C12N5/0694 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , C12N5/0639 , C12N2501/15 , C12N2501/22 , C12N2501/24 , C12N2501/25 , C12N2501/39 , C12N2510/00
摘要： The invention is related to the production and use of CD124+ and CD116+ cell lines for the production of effective dendritic cells (DC) using stimulatory molecules, their use in the production of allogenic or semi-allogenic immunotherapeutic agents and the use thereof in the treatment or prophylaxis of immune diseases. Furthermore, the invention is related to the use of CD124+ and CD116+ tumor cell lines, preferably also being CD34+, as model and yeast systems for testing the DC biology and for testing substances having an impact on the immune system and on the conditioning thereof.
摘要翻译： 本发明涉及使用刺激分子生产有效树突状细胞（DC）的CD124 +和CD116 +细胞系的生产和使用，它们在同种异体或半同种异体免疫治疗剂的生产中的用途及其在治疗或 预防免疫疾病。 此外，本发明涉及使用CD124 +和CD116 +肿瘤细胞系，优选也是CD34 +，作为用于测试DC生物学和测试对免疫系统和其调节影响的物质的模型和酵母系统。
-
公开(公告)号：US20060292643A1
公开(公告)日：2006-12-28
申请号：US10540479
申请日：2004-01-23
申请人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
发明人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
IPC分类号： G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/30
CPC分类号： C07K16/3092 , A61K51/08 , A61K51/088 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.
摘要翻译： 本发明涉及指向肿瘤的识别分子，并且还涉及包含所述识别分子的药物组合物，用于产生所述识别分子的方法，以及所述识别分子在肿瘤疾病的诊断和治疗中的用途。
-
16.发明申请公开(公告)号：US20060127419A1
公开(公告)日：2006-06-15
申请号：US10524738
申请日：2003-08-18
申请人： Steffen Goletz , Hans Baumeister , Ute Schober
发明人： Steffen Goletz , Hans Baumeister , Ute Schober
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , C12N5/0693
摘要： The present invention relates to a process for the production of an immunogenic compound comprising inducing necrosis by temperature in tumor cells and lysing said necrotic tumor cells so as to obtain a lysate. Furthermore, the invention provides a method for the production of a pharmaceutical composition. Additionally, the invention relates to a pharmaceutical composition comprising a lysate obtainable by the aforementioned process. Moreover, methods and uses for vaccination against cancers, tumorous diseases, infections and/or autoimmune diseases comprising administering the cell lysates of the invention or dendritic cells loaded with the cell lysate loaded to an individual are provided.
-
公开(公告)号：US09527899B2
公开(公告)日：2016-12-27
申请号：US13814059
申请日：2011-08-04
申请人： Steffen Goletz , Lars Stöckl
发明人： Steffen Goletz , Lars Stöckl
摘要： The present invention pertains to improved FSH preparations which are capable of stimulating sex steroid release at much lower concentration than the commonly used urinary FSH or recombinant FSH obtained from CHO cells and which act independent of cAMP signaling These improved FSH preparations can be used in infertility treatment.
摘要翻译： 本发明涉及改进的FSH制剂，其能够以比常规使用的尿FSH或从CHO细胞获得的重组FSH更低的浓度刺激性类固醇释放，并且其独立于cAMP信号。这些改进的FSH制剂可用于不孕症治疗 。
-
公开(公告)号：US20150118354A1
公开(公告)日：2015-04-30
申请号：US14239934
申请日：2012-08-22
CPC分类号： A23L29/065 , A23C9/1203 , A23L33/135 , A23V2002/00 , C12N1/20 , C12R1/01 , A23V2200/30 , A23V2200/3204
摘要： The present invention pertains to food products comprising microorganisms of the species Bacteroides xylanisolvens, in particular fermented food and probiotic food. These microorganisms are particularly characterized as having a very low pathogenicity and a high safety for human consumption. Furthermore, methods for producing said food products, in particular by fermentation, as well as suitable bacterial strains Bacteroides xylanisolvens of are provided.
摘要翻译： 本发明涉及包含拟杆菌木聚糖异构酶的微生物，特别是发酵食品和益生菌食品的食品。 这些微生物的特征在于具有非常低的致病性和对人类消费的高安全性。 此外，提供了特别是通过发酵生产所述食品的方法以及合适的细菌菌株木霉菌木聚糖溶酶。
-
公开(公告)号：US08779102B2
公开(公告)日：2014-07-15
申请号：US10540479
申请日：2004-01-23
申请人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
发明人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
IPC分类号： C12P21/08
CPC分类号： C07K16/3092 , A61K51/08 , A61K51/088 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising such recognition molecules, methods for the production of such recognition molecules, and to the use of such recognition molecules in the diagnosis and therapy of tumor diseases.
摘要翻译： 本发明涉及针对肿瘤的识别分子，并且还涉及包含这种识别分子的药物组合物，用于产生这种识别分子的方法，以及这些识别分子在肿瘤疾病的诊断和治疗中的应用。
-
公开(公告)号：US08617846B2
公开(公告)日：2013-12-31
申请号：US13302698
申请日：2011-11-22
申请人： Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
发明人： Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
IPC分类号： C12P21/08 , C07K16/30 , A61K39/395
CPC分类号： A61K51/1045 , A61K47/6851 , A61K47/6903 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.
摘要翻译： 本发明涉及指向肿瘤并可用于诊断和治疗肿瘤疾病的识别分子。
-
-
-
-
-
-
-
-
-
搜索结果
43 条记录 (耗时 0.029 秒)
