摘要:
A process for the manufacture of bioerodible poly(ortho ester)s and polyacetals containing beneficial agents having a hydroxyl functionality of two or more and their fabrication into controlled release dosage forms having a reproducible delivery of the beneficial agent into the biological environment of use are disclosed.
摘要:
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
摘要:
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
摘要:
A high energy density capacitor comprising an organic polymeric dielectric material having a dielectric constant of at least about 7; wherein the organic polymeric dielectric material comprises polymerized alkyl (alpha-substituted)acrylate monomers having at least one dipole group; wherein when the monomers are polymerized, the dipole group is attached to the main polymeric chain through a heteroatom-containing linking group.
摘要:
A band-shaped annuloplasty device (e.g., C- or D-shaped ring) that is relatively rigid during handling and implantation and becomes relatively complaint after implantation. Preferably, the device includes a core material that softens after implantation.
摘要:
A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine, 6-mercaptopurine, 5-fluorouracil, the penicillin antibiotics, the cephalosporin antibiotics, and the 1-oxacephalosporin antibiotics to form a prodrug which, when injected into animal tissue, undergoes natural conversion in the physiological environment to provide controlled release of the drug or an active drug complex.
摘要:
An implantable medical device comprising a drug-loaded polymer overlaid with a fabric that promotes tissue ingrowth is useful in a wide variety of tissue engineering applications. The invention includes, for example, prosthetic heart valves, annuloplasty rings, and grafts, having enhanced biocompatibility and biostability. Methods of making and using the implantable medical devices of the invention are also included.
摘要:
A high energy density capacitor comprising an organic polymeric dielectric material having a dielectric constant of at least about 7; wherein the organic polymeric dielectric material comprises polymerized alkyl (alpha-substituted)acrylate monomers having at least one dipole group; wherein when the monomers are polymerized, the dipole group is attached to the main polymeric chain through a heteroatom-containing linking group.
摘要:
A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl ethers which delivers beneficial agents to a biological environment of use. A statistically significant portion of the beneficial agent is covalently bonded within the polymer matrix.
摘要:
The instant invention is directed to a bioerodible poly(ortho ester) thermoplastic elastomer prepared from:(A) a diketene diacetal;(B) a long-chain non-polar, flexible diol containing 4 to 22 carbon atoms; and(C) a diol selected from the group consisting of:(i) diols containing at least one functional group which produces hydrogen bonding or other association, and(ii) rigid symmetrical diols.