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1.发明授权Implantable medical device with enhanced biocompatibility and biostability 有权具有增强生物相容性和生物稳定性的植入式医疗器械公开(公告)号：US07658727B1
公开(公告)日：2010-02-09
申请号：US09301842
申请日：1999-04-29
申请人： Brian C. A. Fernandes , Maura G. Donovan , Randall V. Sparer , Jesus W. Casas-Bejar , Mark W. Torrianni
发明人： Brian C. A. Fernandes , Maura G. Donovan , Randall V. Sparer , Jesus W. Casas-Bejar , Mark W. Torrianni
IPC分类号： A61M5/32
CPC分类号： A61F2/2445 , A61F2/24 , A61F2/2403 , A61F2250/0067 , A61L27/34 , A61L27/40 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L2300/102 , A61L2300/41 , C08L75/04
摘要： An implantable medical device comprising a drug-loaded polymer overlaid with a fabric that promotes tissue ingrowth is useful in a wide variety of tissue engineering applications. The invention includes, for example, prosthetic heart valves, annuloplasty rings, and grafts, having enhanced biocompatibility and biostability. Methods of making and using the implantable medical devices of the invention are also included.
摘要翻译： 包括覆盖有促进组织向内生长的织物的载药聚合物的可植入医疗装置可用于各种组织工程应用。 本发明包括例如具有增强的生物相容性和生物稳定性的假体心脏瓣膜，瓣膜成形术环和移植物。 还包括制造和使用本发明的可植入医疗器械的方法。
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公开(公告)号：US08691258B2
公开(公告)日：2014-04-08
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
发明人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。
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公开(公告)号：US06810286B2
公开(公告)日：2004-10-26
申请号：US09799304
申请日：2001-03-05
申请人： Maura G. Donovan , Orhan Soykan , D. Curtis Deno , Lawrence J. Mulligan , Brian C. A. Fernandes
发明人： Maura G. Donovan , Orhan Soykan , D. Curtis Deno , Lawrence J. Mulligan , Brian C. A. Fernandes
IPC分类号： A61N100
CPC分类号： A61N1/326
摘要： Provided are novel stimulatory device for the controlled production of angiogenic growth factors. More specifically, a subthreshold pulse generator is used for the local production of vascular endothelial growth factor.
摘要翻译： 提供了用于受控制造血管生成生长因子的新型刺激装置。 更具体地，使用亚阈值脉冲发生器用于血管内皮生长因子的局部产生。
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4.发明申请Method of increasing retention, survival and proliferation of transplanted cells in vivo 审中-公开增加体内移植细胞的保留，存活和增殖的方法公开(公告)号：US20080089867A1
公开(公告)日：2008-04-17
申请号：US11580603
申请日：2006-10-13
CPC分类号： A61L27/3839 , A61K35/16 , A61K35/19 , A61K35/34 , A61L27/3886 , C12N5/0068 , C12N5/0691 , C12N2533/90 , A61K2300/00
摘要： A method of increasing retention, survival and proliferation of transplanted cells in diseased or damaged tissue types or organ by providing transplanted cells with autologously-derived platelet cells and forming a autologously-derived platelet gel prior or during administration to the tissue type or organ through a delivery device and immobilizing the transplanted cells in the tissue type or organ system.
摘要翻译： 通过在组织类型或器官给药之前或期间通过提供自体衍生的血小板细胞移植细胞并形成自体衍生的血小板凝胶来增加患病或受损组织类型或器官中移植细胞的保留，存活和增殖的方法， 递送装置并将移植的细胞固定在组织类型或器官系统中。
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公开(公告)号：US06775574B1
公开(公告)日：2004-08-10
申请号：US09654185
申请日：2000-09-01
申请人： Orhan Soykan , Maura G. Donovan
发明人： Orhan Soykan , Maura G. Donovan
IPC分类号： A61N108
CPC分类号： A61N1/36042 , A61N1/326 , A61N1/362 , A61N1/37205 , A61N1/3756 , C12N5/0657
摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium.
摘要翻译： 提供了一种可植入系统，其包括：包含遗传物质，未分化的收缩细胞或能够在患者心肌的梗塞区域内和/或附近形成新的收缩组织的组合的细胞增殖源; 以及用于电刺激患者心肌梗死区域内和/或附近的新的收缩组织的电刺激装置。
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公开(公告)号：US06228845B1
公开(公告)日：2001-05-08
申请号：US09176519
申请日：1998-10-21
申请人： Maura G. Donovan , Paul M. Stein
发明人： Maura G. Donovan , Paul M. Stein
IPC分类号： A61M3100
CPC分类号： A61F2/82 , A61F2/07 , A61F2250/0067 , C12N15/87
摘要： This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.
摘要翻译： 本发明涉及具有管腔壁接触表面和内腔暴露表面的管腔内支架，其中所述支架包括包含纤维蛋白的第一聚合物组合物，并且其中所述支架适于将病毒递送至所述身体的内腔壁。 本发明还涉及用于制备支架的方法和用于将核酸输送到从体腔壁可接近的细胞的方法。
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公开(公告)号：US20080227083A1
公开(公告)日：2008-09-18
申请号：US12127908
申请日：2008-05-28
申请人： Orhan Soykan , Maura G. Donovan
发明人： Orhan Soykan , Maura G. Donovan
CPC分类号： A61B5/14546 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4839 , A61B5/7203 , C12Q1/37 , C12Q1/56 , G01N21/6428 , G01N21/8507 , G01N33/86 , G01N2021/6415 , G01N2021/6441 , G01N2021/6484 , G01N2021/8528
摘要： Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy, at the second and third wavelengths.
摘要翻译： 基于酶的底物的切割量检测体液中酶的活化。 用两种荧光染料 - 供体和受体标记底物。 标记的基质被呈现给体液。 器件将第一波长的能量发射到体液中，并响应于第一波长的能量，检测由染料发射的第二和第三波长处的能量。 在衬底的酶切割之前，受体以响应于通过来自供体的荧光共振能量转移（FRET）接收的第二波长的能量而在第三波长处发射能量。 在酶切割底物之后，供体在第二波长处发射能量。 该装置可以基于在第二和第三波长处的能量的相对强度来确定体液中活化酶的浓度。
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公开(公告)号：US06671558B1
公开(公告)日：2003-12-30
申请号：US09706531
申请日：2000-11-03
申请人： Orhan Soykan , Maura G. Donovan
发明人： Orhan Soykan , Maura G. Donovan
IPC分类号： A61N108
CPC分类号： A61N1/36042
摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated and/or differentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium or otherwise damaged or diseased myocardial tissue.
摘要翻译： 提供了一种可植入系统，其包括：包含遗传材料，未分化和/或分化的收缩细胞或能够在患者心肌的梗塞区域内和/或附近形成新的收缩组织的组合的细胞增殖源; 以及电刺激装置，用于电刺激患者心肌梗死区或其它受损或患病心肌组织中和/或附近的新收缩组织。
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公开(公告)号：US6151525A
公开(公告)日：2000-11-21
申请号：US145743
申请日：1998-09-02
申请人： Orhan Soykan , Maura G. Donovan
发明人： Orhan Soykan , Maura G. Donovan
CPC分类号： A61N1/36042 , A61N1/37205
摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium.
摘要翻译： 提供了一种可植入系统，其包括：包含遗传物质，未分化的收缩细胞或能够在患者心肌的梗塞区域内和/或附近形成新的收缩组织的组合的细胞增殖源; 以及用于电刺激患者心肌梗死区域内和/或附近的新的收缩组织的电刺激装置。
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公开(公告)号：US5833651A
公开(公告)日：1998-11-10
申请号：US746404
申请日：1996-11-08
申请人： Maura G. Donovan , Paul M. Stein
发明人： Maura G. Donovan , Paul M. Stein
CPC分类号： A61F2/82 , C12N15/87 , A61F2/07 , A61F2250/0067
摘要： This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.
摘要翻译： 本发明涉及具有管腔壁接触表面和内腔暴露表面的管腔内支架，其中所述支架包括包含纤维蛋白的第一聚合物组合物，并且其中所述支架适于将病毒递送至所述身体的内腔壁。 本发明还涉及用于制备支架的方法和用于将核酸输送到从体腔壁可接近的细胞的方法。
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