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公开(公告)号：US20120328770A1
公开(公告)日：2012-12-27
申请号：US13605795
申请日：2012-09-06
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D7/00
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译： 公开了调节药物涂层支架释放速率的方法。
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公开(公告)号：US08293318B1
公开(公告)日：2012-10-23
申请号：US11847222
申请日：2007-08-29
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译： 公开了调节药物涂层支架释放速率的方法。
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13.发明授权Medical device coated with a coating containing elastin pentapeptide VGVPG 有权涂有含有弹性蛋白五肽VGVPG的涂层的医疗器械公开(公告)号：US08029816B2
公开(公告)日：2011-10-04
申请号：US11803031
申请日：2007-05-10
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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14.发明授权公开(公告)号：US08377116B2
公开(公告)日：2013-02-19
申请号：US12052452
申请日：2008-03-20
申请人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L31/10 , A61L2420/08 , C08L67/04
摘要： The present invention provides an implantable medical device coating that has improved stability, a medical device coated with such coating, and a method of increasing the stability of an implantable medical device coating, wherein the coating comprises a stereocomplex f poly(D-lactic acid) and poly(L-lactice acid).
摘要翻译： 本发明提供了具有改善的稳定性的可植入医疗装置涂层，涂覆有这种涂层的医疗装置以及增加可植入医疗装置涂层的稳定性的方法，其中所述涂层包含立体络合物f聚（D-乳酸） 和聚（L-乳酸））。
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公开(公告)号：US20090036978A1
公开(公告)日：2009-02-05
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
摘要翻译： 本发明涉及涂覆有具有可调谐疏水性的聚合物的可植入医疗装置及其在治疗血管疾病中的用途。
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公开(公告)号：US07311980B1
公开(公告)日：2007-12-25
申请号：US10910453
申请日：2004-08-02
申请人： Syed F. A. Hossainy , Yiwen Tang , Gina Zhang
发明人： Syed F. A. Hossainy , Yiwen Tang , Gina Zhang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/08 , Y10T428/139 , Y10T428/1393 , Y10T428/29 , Y10T428/31786 , C08L71/02 , C08L67/04
摘要： A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided.
摘要翻译： 提供了一种用于医疗装置的聚合物涂层，其包含聚（乳酸）和包含聚（乙二醇）和聚（对苯二甲酸丁二醇酯）的嵌段的嵌段共聚物。
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17.发明申请公开(公告)号：US20060093842A1
公开(公告)日：2006-05-04
申请号：US10976551
申请日：2004-10-29
申请人： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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18.发明授权公开(公告)号：US07749263B2
公开(公告)日：2010-07-06
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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19.发明申请Morphology profiles for control of agent release rates from polymer matrices 审中-公开用于控制聚合物基质的试剂释放速率的形态概况公开(公告)号：US20080124372A1
公开(公告)日：2008-05-29
申请号：US11448956
申请日：2006-06-06
申请人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
发明人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC分类号： A61F2/06 , B05D3/00 , A61K47/48 , A61K31/436 , A61K31/337 , A61K31/46 , A61P9/00
CPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
摘要翻译： 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。
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20.发明申请公开(公告)号：US20080167712A1
公开(公告)日：2008-07-10
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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