公开(公告)号：US20200010487A1

公开(公告)日：2020-01-09

申请号：US16576293

申请日：2019-09-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC: C07F7/08 ,  C07D205/04 ,  C07D207/12 ,  C07K5/065 ,  C07K5/087

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20180319812A1

公开(公告)日：2018-11-08

申请号：US16035277

申请日：2018-07-13

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Hiroyuki Watanabe ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Yoshihide Tomata ,  Naoki Ishii ,  Michiko Tawada ,  Mitsunori Kono ,  Atsuko Ochida ,  Takashi Imada ,  Yoshiyuki Fukase ,  Tomoya Yukawa

IPC: C07D491/056 ,  C07F7/08 ,  C07D217/26 ,  C07D413/12 ,  C07D401/12 ,  C07D405/12 ,  C07D401/04 ,  C07D413/14 ,  C07D491/048 ,  C07D471/04 ,  C07D417/06 ,  C07D413/06 ,  C07D409/06 ,  C07D405/06 ,  C07D401/06 ,  C07D491/04

CPC classification number: C07D491/056 ,  C07D217/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07F7/0812

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.

公开(公告)号：US09365520B2

公开(公告)日：2016-06-14

申请号：US14755439

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Tsuneo Oda ,  Mitsunori Kono ,  Atsuko Ochida ,  Takashi Imada ,  Hidekazu Tokuhara ,  Yoshihide Tomata ,  Naoki Ishii ,  Michiko Tawada ,  Yoshiyuki Fukase ,  Tomoya Yukawa ,  Shoji Fukumoto

IPC: C07D471/04 ,  C07D215/00 ,  C07D491/14 ,  C07D217/26 ,  C07F7/08 ,  C07D491/048 ,  C07D491/056 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。

公开(公告)号：US11584737B2

公开(公告)日：2023-02-21

申请号：US17042394

申请日：2019-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Koji Ono ,  Masahiro Ito ,  Toshio Tanaka ,  Moriteru Asano ,  Takaharu Hirayama ,  Jun Fujimoto ,  Nobuki Sakauchi ,  Yasuhiro Hirata ,  Akinori Toita ,  Nao Morishita ,  Hironori Kokubo ,  Yasuhiro Imaeda ,  Hironobu Maezaki ,  Douglas Robert Cary ,  Ryo Mizojiri ,  Nobuo Cho ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Yasuyoshi Arikawa

IPC: C07D401/14 ,  C07D403/14 ,  A61P35/00 ,  C07D213/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D471/10 ,  C07D487/10 ,  C07D495/10

Abstract: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US11407748B2

公开(公告)日：2022-08-09

申请号：US16753613

申请日：2018-10-04

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinji Nakamura ,  Satoshi Mikami ,  Tomoaki Hasui ,  Tohru Yamashita ,  Shinji Morimoto ,  Hidekazu Tokuhara ,  Norio Oyabu ,  Masami Yamada ,  Atsuko Ochida ,  Kazuaki Takami ,  Xin Liu

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  A61K9/20 ,  C07D519/00

Abstract: The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US11230545B2

公开(公告)日：2022-01-25

申请号：US17367171

申请日：2021-07-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Toshio Tanaka ,  Yasuyoshi Arikawa ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D471/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US10472376B2

公开(公告)日：2019-11-12

申请号：US14902388

申请日：2014-07-02

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC: C07F7/08 ,  C07D309/06 ,  C07D405/12 ,  C07D239/36 ,  C07D413/12 ,  C07D205/04 ,  C07C237/22 ,  C07D207/12 ,  C07D271/10 ,  C07F7/10 ,  C07F7/30 ,  C07K5/065 ,  C07D309/08 ,  C07D231/12 ,  C07D231/56 ,  C07D333/38 ,  C07D233/72 ,  C07D403/06 ,  C07D237/14 ,  C07D239/54 ,  C07K5/087

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US09630924B2

公开(公告)日：2017-04-25

申请号：US15055108

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Tsuneo Oda ,  Mitsunori Kono ,  Atsuko Ochida ,  Takashi Imada ,  Hidekazu Tokuhara ,  Yoshihide Tomata ,  Naoki Ishii ,  Michiko Tawada ,  Yoshiyuki Fukase ,  Tomoya Yukawa ,  Shoji Fukumoto

IPC: C07D471/04 ,  C07D215/00 ,  C07D217/26 ,  C07F7/08 ,  C07D491/048 ,  C07D491/056 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D491/14

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US10323026B2

公开(公告)日：2019-06-18

申请号：US15474192

申请日：2017-03-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shuhei Ikeda ,  Hideyuki Sugiyama ,  Jumpei Aida ,  Hidekazu Tokuhara ,  Tomohiro Okawa ,  Yuya Oguro ,  Minoru Nakamura ,  Masataka Murakami

IPC: C07D413/14 ,  C07D401/08 ,  C07D405/14 ,  C07D413/08 ,  C07D401/06 ,  C07D413/06

Abstract: The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10093629B2

公开(公告)日：2018-10-09

申请号：US15321609

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Tsuneo Oda ,  Mitsunori Kono ,  Atsuko Ochida ,  Takashi Imada ,  Hidekazu Tokuhara ,  Yoshihide Tomata ,  Naoki Ishii ,  Michiko Tawada ,  Yoshiyuki Fukase ,  Tomoya Yukawa ,  Shoji Fukumoto

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D491/14

Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.