公开(公告)号：US12016948B2

公开(公告)日：2024-06-25

申请号：US16475894

申请日：2018-01-05

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Liangfang Zhang

IPC: A61K9/46 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61B5/00

CPC classification number: A61K9/0007 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/204 ,  A61K9/205 ,  A61K9/2086 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5036 ,  A61B5/4222

Abstract: Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.

公开(公告)号：US20180153821A1

公开(公告)日：2018-06-07

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

CPC classification number: A61K9/5176 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/337 ,  A61K47/6901 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US20180140558A1

公开(公告)日：2018-05-24

申请号：US15568316

申请日：2016-04-13

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Zhiqing Pang ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K9/50 ,  A61K45/06

CPC classification number: A61K9/5176 ,  A61K9/5068 ,  A61K45/06

Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.

公开(公告)号：US20170079909A1

公开(公告)日：2017-03-23

申请号：US15126342

申请日：2015-03-20

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61L27/54 ,  A61K9/00 ,  A61L27/52

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K9/1629 ,  A61K9/5068 ,  A61K9/5115 ,  A61K9/5153 ,  A61K9/5176 ,  A61K31/49 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K38/1709 ,  A61K45/06 ,  A61L26/008 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/12 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US20160136106A1

公开(公告)日：2016-05-19

申请号：US15000110

申请日：2016-01-19

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  G01N33/58 ,  G01N33/569 ,  A61K31/4709 ,  A61K49/00

CPC classification number: A61K9/5176 ,  A61K9/5094 ,  A61K9/51 ,  A61K9/5153 ,  A61K31/4709 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K49/00 ,  G01N33/56905 ,  G01N33/587 ,  G01N2333/445 ,  Y02A50/411 ,  Y02A50/473

Abstract: Provided are methods, combinations and pharmaceutical compositions for treating or preventing an infection in a subject using a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane configured for adhesion of a pathogen that causes said infection. Exemplary infection includes infection caused by a virus, bacterium, fungus, or protozoan.

Abstract translation: 提供了使用纳米颗粒治疗或预防受试者感染的方法，组合和药物组合物，所述纳米颗粒包含a）包含非细胞材料的内核，和b）包含被配置用于粘附病原体的细胞膜的外表面， 导致感染。 示例性感染包括由病毒，细菌，真菌或原生动物引起的感染。

公开(公告)号：US20240252438A1

公开(公告)日：2024-08-01

申请号：US18582123

申请日：2024-02-20

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming (Jack) Hu ,  Ronnie Hongbo Fang ,  Jonathan Copp

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06

CPC classification number: A61K9/148 ,  A61K39/001102 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55555 ,  A61K2039/80

Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.

公开(公告)号：US20220331365A1

公开(公告)日：2022-10-20

申请号：US17639895

申请日：2020-09-01

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Ronnie H. Fang ,  Jia Zhuang ,  Weiwei Gao

IPC: A61K35/18 ,  A61K9/127 ,  A61K31/02 ,  A61P9/10

Abstract: A biomimetic oxygen delivery carrier is provided by employing natural cell membrane as a stabilizer for fluorocarbon nanoemulsions. The resulting formulation exhibits a high capacity for delivering oxygen and can be used to successfully resuscitate subjects in need due to for example hemorrhagic shock. This natural-synthetic platform can alleviate the impact of blood shortages in clinical settings among other uses.

公开(公告)号：US20220221464A1

公开(公告)日：2022-07-14

申请号：US17607200

申请日：2020-04-30

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Wei Wang

IPC: G01N33/574 ,  C12Q1/6874 ,  C12Q1/6886 ,  G01N33/543 ,  G01N33/554

Abstract: Described are methods, compositions, and devices for early detection and prevention of diseases, including cancer, infectious diseases, and autoimmune diseases, using broad-spectrum enrichment technology and single cell sequencing technology. An example method for detecting circulating tumor cells (CTCs) using platelet membrane-coated nanoparticles (PNPs) and single cell RNA sequencing (scRNA-seq) technology is also provided.

公开(公告)号：US11007147B2

公开(公告)日：2021-05-18

申请号：US16811515

申请日：2020-03-06

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61K9/16 ,  A61K9/51 ,  A61K38/17 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K45/06 ,  A61K31/49 ,  A61L26/00 ,  A61K9/00 ,  A61L27/52 ,  A61L27/54 ,  A61K9/50

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US11000593B2

公开(公告)日：2021-05-11

申请号：US16067950

申请日：2017-01-05

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao

IPC: A61K9/16 ,  A61K47/34 ,  A61K9/00 ,  A61K35/39 ,  C12N5/071

Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.